SYRE vs JXN

Comparison between Spyre Therapeutics Inc (SYRE, Company) and Jackson Financial Inc - Class A (JXN, Company).

SYRE is from the Healthcare sector, while JXN is from the Financial Services sector.

5-Year PerformanceJXN has outperformed SYRE, delivering a return of +39.8% compared to -8.5%

SYRE vs JXN - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SYRE(COMPANY)	JXN(COMPANY)
Market Cap	$9.19B	$9.18B
Max Drawdown	99.11%	49.12%
Sharpe Ratio	2.99	1.19
5Y Beta	1.79	1.39
Industry	Biotechnology	Insurance - Life
P/E Ratio	-45.95	82.46
PEG Ratio	N/A	0.50
Dividend Yield	N/A	2.55%
5Y EPS CAGR	-2.73%	N/A
Debt to Equity	0.00%	27.80%
Free Cash Flow Yield	-2.27%	64.14%
P/S Ratio	650.22	1.43
P/B Ratio	16.58	0.95

Market Cap

Winner

SYRE

$9.19B

JXN

$9.18B

Max Drawdown

SYRE

99.11%

Winner

JXN

49.12%

Sharpe Ratio

Winner

SYRE

2.99

JXN

1.19

5Y Beta

SYRE

1.79

Winner

JXN

1.39

Industry

SYRE

Biotechnology

JXN

Insurance - Life

P/E Ratio

Winner

SYRE

-45.95

JXN

82.46

PEG Ratio

SYRE

N/A

JXN

0.50

Dividend Yield

SYRE

N/A

JXN

2.55%

5Y EPS CAGR

SYRE

-2.73%

JXN

N/A

Debt to Equity

Winner

SYRE

0.00%

JXN

27.80%

Free Cash Flow Yield

SYRE

-2.27%

Winner

JXN

64.14%

P/S Ratio

SYRE

650.22

Winner

JXN

1.43

P/B Ratio

SYRE

16.58

Winner

JXN

0.95

SYRE vs JXN - Historical Returns

Returns include dividend reinvestment.

Period	SYRE	JXN
1 month	+11.33%	+18.92%
3 months	+43.52%	+19.03%
6 months	+198.72%	+10.44%
1 year	+588.39%	+51.10%
5 years(CAGR)	-8.54%	+39.80%
10 years(CAGR)	-0.91%	N/A
Max(CAGR)	-7.85%	+39.80%

SYRE

+11.33%

Winner

JXN

+18.92%

Winner

SYRE

+43.52%

JXN

+19.03%

Winner

SYRE

+198.72%

JXN

+10.44%

Winner

SYRE

+588.39%

JXN

+51.10%

5Y(CAGR)

SYRE

-8.54%

Winner

JXN

+39.80%

10Y(CAGR)

SYRE

-0.91%

JXN

N/A

Max(CAGR)

SYRE

-7.85%

Winner

JXN

+39.80%

SYRE vs JXN - Annual Returns (2016 - 2026)

Returns include dividend reinvestment.

Year	SYRE	JXN
2026	+243.07%	+23.00%
2025	+37.36%	+25.94%
2024	+8.79%	+79.11%
2023	+104.27%	+58.27%
2022	-90.57%	-12.59%
2021	-44.51%	+34.92%
2020	+1.55%	N/A
2019	-4.98%	N/A
2018	+39.22%	N/A
2017	+18.38%	N/A
2016	-55.48%	N/A

SYRE vs JXN Drawdown Comparison

The maximum drawdown for SYRE was -99.11%, occurring on Jun 21, 2023. This drawdown has not yet recovered.

The maximum drawdown for JXN was -48.33%, occurring on Jul 14, 2022. Recovery took 214 trading sessions.

The current SYRE drawdown is -65.00%. The current JXN drawdown is -3.42%.

Rank	SYRE	JXN
#1	-99.11% Apr 8, 2016 - Jun 21, 2023	-48.33% Mar 25, 2022 - Feb 1, 2023
#2	N/A	-41.41% Feb 17, 2023 - Nov 27, 2023
#3	N/A	-37.09% Nov 6, 2024 - Jan 5, 2026
#4	N/A	-23.00% Jan 10, 2022 - Mar 25, 2022
#5	N/A	-21.53% Jul 31, 2024 - Aug 16, 2024
#6	N/A	-21.46% Sep 1, 2021 - Nov 11, 2021
#7	N/A	-16.31% Feb 2, 2026 - Jul 13, 2026
#8	N/A	-11.67% Nov 17, 2021 - Dec 6, 2021
#9	N/A	-11.27% Aug 30, 2024 - Sep 19, 2024
#10	N/A	-11.17% May 9, 2024 - Jul 12, 2024
#11	N/A	-7.49% Jul 16, 2026 - Aug 3, 2026
#12	N/A	-7.46% Dec 19, 2023 - Feb 12, 2024
#13	N/A	-6.93% Aug 16, 2024 - Aug 30, 2024
#14	N/A	-6.10% Apr 3, 2024 - Apr 23, 2024
#15	N/A	-5.92% Jan 9, 2026 - Jan 29, 2026