SYRE vs INFA

Comparison between Spyre Therapeutics Inc (SYRE, Company) and Informatica Inc. (INFA, Company).

SYRE is from the Healthcare sector, while INFA is from the Technology sector.

5-Year PerformanceINFA has outperformed SYRE, delivering a return of -3.3% compared to -9.4%

SYRE vs INFA - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SYRE(COMPANY)	INFA(COMPANY)
Market Cap	$7.82B	$7.80B
Max Drawdown	99.11%	63.71%
Sharpe Ratio	2.87	0.15
5Y Beta	1.75	0.57
Industry	Biotechnology	Software - Infrastructure
P/E Ratio	-40.18	755.27
Forward P/E	N/A	19.16
5Y EPS CAGR	-2.15%	N/A
Debt to Equity	0.00%	73.42%
Free Cash Flow Yield	-2.37%	5.98%
P/S Ratio	650.22	4.64
P/B Ratio	17.32	3.18

Market Cap

Winner

SYRE

$7.82B

INFA

$7.80B

Max Drawdown

SYRE

99.11%

Winner

INFA

63.71%

Sharpe Ratio

Winner

SYRE

2.87

INFA

0.15

5Y Beta

SYRE

1.75

Winner

INFA

0.57

Industry

SYRE

Biotechnology

INFA

Software - Infrastructure

P/E Ratio

Winner

SYRE

-40.18

INFA

755.27

Forward P/E

SYRE

N/A

INFA

19.16

5Y EPS CAGR

SYRE

-2.15%

INFA

N/A

Debt to Equity

Winner

SYRE

0.00%

INFA

73.42%

Free Cash Flow Yield

SYRE

-2.37%

Winner

INFA

5.98%

P/S Ratio

SYRE

650.22

Winner

INFA

4.64

P/B Ratio

SYRE

17.32

Winner

INFA

3.18

SYRE vs INFA - Historical Returns

Returns include dividend reinvestment.

Period	SYRE	INFA
1 month	+3.03%	+0.00%
3 months	+44.41%	N/A
6 months	+212.13%	+0.00%
1 year	+461.43%	+1.02%
5 years(CAGR)	-9.42%	-3.26%
10 years(CAGR)	-1.50%	N/A
Max(CAGR)	-8.31%	-3.26%

Winner

SYRE

+3.03%

INFA

+0.00%

SYRE

+44.41%

INFA

N/A

Winner

SYRE

+212.13%

INFA

+0.00%

Winner

SYRE

+461.43%

INFA

+1.02%

5Y(CAGR)

SYRE

-9.42%

Winner

INFA

-3.26%

10Y(CAGR)

SYRE

-1.50%

INFA

N/A

Max(CAGR)

SYRE

-8.31%

Winner

INFA

-3.26%

SYRE vs INFA - Annual Returns (2016 - 2026)

Returns include dividend reinvestment.

Year	SYRE	INFA
2026	+226.98%	+0.00%
2025	+37.36%	-2.63%
2024	+8.79%	-3.78%
2023	+104.27%	+83.99%
2022	-90.57%	-54.69%
2021	-44.51%	+27.52%
2020	+1.55%	N/A
2019	-4.98%	N/A
2018	+39.22%	N/A
2017	+18.38%	N/A
2016	-55.48%	N/A

SYRE vs INFA Drawdown Comparison

The maximum drawdown for SYRE was -99.11%, occurring on Jun 21, 2023. This drawdown has not yet recovered.

The maximum drawdown for INFA was -63.71%, occurring on May 4, 2023. This drawdown has not yet recovered.

The current SYRE drawdown is -66.64%. The current INFA drawdown is -36.16%.

Rank	SYRE	INFA
#1	-99.11% Apr 8, 2016 - Jun 21, 2023	-63.71% Dec 15, 2021 - May 4, 2023
#2	N/A	-6.42% Nov 29, 2021 - Dec 7, 2021
#3	N/A	-5.63% Dec 10, 2021 - Dec 15, 2021
#4	N/A	-4.63% Nov 18, 2021 - Nov 29, 2021
#5	N/A	-3.82% Dec 8, 2021 - Dec 10, 2021
#6	N/A	-2.56% Nov 15, 2021 - Nov 18, 2021
#7	N/A	-1.67% Nov 9, 2021 - Nov 15, 2021
#8	N/A	-0.64% Nov 4, 2021 - Nov 8, 2021
#9	N/A	-0.03% Oct 29, 2021 - Nov 2, 2021