SEPN vs QCRH
Comparison between Septerna Inc (SEPN, Company) and QCR Holding Inc (QCRH, Company).
SEPN is from the Healthcare sector, while QCRH is from the Financial Services sector.
SEPN vs QCRH - Performance Comparison
Key Characteristics
Financial metrics and valuation ratios
Market Cap
Winner
SEPN
$1.74B
QCRH
$1.74B
Max Drawdown
SEPN
81.47%
Winner
QCRH
68.99%
Sharpe Ratio
Winner
SEPN
2.10
QCRH
1.55
5Y Beta
SEPN
1.27
Winner
QCRH
0.77
Industry
SEPN
Biotechnology
QCRH
Banks - Regional
P/E Ratio
Winner
SEPN
-48.08
QCRH
13.08
Forward P/E
SEPN
107.53
Winner
QCRH
12.20
PEG Ratio
SEPN
N/A
QCRH
0.64
Dividend Yield
SEPN
N/A
QCRH
0.12%
5Y Dividends CAGR
SEPN
N/A
QCRH
4.84%
5Y EPS CAGR
SEPN
N/A
QCRH
13.59%
Debt to Equity
Winner
SEPN
0.00%
QCRH
0.17%
Free Cash Flow Yield
SEPN
6.14%
Winner
QCRH
20.65%
P/S Ratio
SEPN
24.18
Winner
QCRH
4.55
P/B Ratio
SEPN
4.11
Winner
QCRH
1.50
SEPN vs QCRH - Historical Returns
Returns include dividend reinvestment.
1M
Winner
SEPN
+8.37%
QCRH
+8.31%
3M
Winner
SEPN
+61.93%
QCRH
+13.69%
6M
Winner
SEPN
+52.81%
QCRH
+9.13%
1Y
Winner
SEPN
+231.88%
QCRH
+49.13%
5Y(CAGR)
SEPN
N/A
QCRH
+16.08%
10Y(CAGR)
SEPN
N/A
QCRH
+14.06%
Max(CAGR)
Winner
SEPN
+39.69%
QCRH
+9.23%
SEPN vs QCRH - Annual Returns (1999 - 2026)
Returns include dividend reinvestment.
| Year | SEPN | QCRH |
|---|---|---|
| 2026 | +38.78% | +26.74% |
| 2025 | +30.59% | +5.42% |
| 2024 | +7.01% | +38.47% |
| 2023 | N/A | +18.70% |
| 2022 | N/A | -11.31% |
| 2021 | N/A | +44.02% |
| 2020 | N/A | -7.65% |
| 2019 | N/A | +35.16% |
| 2018 | N/A | -23.06% |
| 2017 | N/A | +1.04% |
| 2016 | N/A | +87.73% |
| 2015 | N/A | +36.17% |
| 2014 | N/A | +5.41% |
| 2013 | N/A | +28.69% |
| 2012 | N/A | +45.74% |
| 2011 | N/A | +26.63% |
| 2010 | N/A | -12.70% |
| 2009 | N/A | -20.54% |
| 2008 | N/A | -29.85% |
| 2007 | N/A | -17.92% |
| 2006 | N/A | -6.63% |
| 2005 | N/A | -8.01% |
| 2004 | N/A | +12.96% |
| 2003 | N/A | +65.20% |
| 2002 | N/A | +47.02% |
| 2001 | N/A | +8.00% |
| 2000 | N/A | -27.02% |
| 1999 | N/A | -19.40% |
SEPN vs QCRH Drawdown Comparison
The maximum drawdown for SEPN was -81.47%, occurring on Apr 1, 2025. Recovery took 230 trading sessions.
The maximum drawdown for QCRH was -67.85%, occurring on Dec 30, 2010. Recovery took 2471 trading sessions.
The current SEPN drawdown is -1.77%. The current QCRH drawdown is -1.40%.
| Rank | SEPN | QCRH |
|---|---|---|
| #1 | -81.47% Dec 23, 2024 - Nov 24, 2025 | -67.85% Jul 26, 2005 - May 20, 2015 |
| #2 | -25.18% Feb 24, 2026 - May 28, 2026 | -52.99% Jul 9, 2018 - Apr 5, 2021 |
| #3 | -21.10% Dec 19, 2025 - Feb 17, 2026 | -46.97% Nov 4, 1999 - Jan 16, 2003 |
| #4 | -16.77% Dec 4, 2024 - Dec 23, 2024 | -41.58% Aug 18, 2022 - Jan 29, 2024 |
| #5 | -16.60% Jul 9, 2026 - Aug 4, 2026 | -32.12% Nov 26, 2024 - Feb 5, 2026 |
| #6 | -16.19% Nov 7, 2024 - Dec 4, 2024 | -17.82% Jan 18, 2022 - Aug 16, 2022 |
| #7 | -13.97% Nov 26, 2025 - Dec 19, 2025 | -17.50% Jan 30, 2004 - Dec 16, 2004 |
| #8 | -10.63% Feb 17, 2026 - Feb 24, 2026 | -15.39% Jun 13, 2017 - Oct 20, 2017 |
| #9 | -10.36% Jun 26, 2026 - Jul 9, 2026 | -15.32% Dec 29, 2015 - Apr 19, 2016 |
| #10 | -6.45% Oct 25, 2024 - Oct 31, 2024 | -15.26% Feb 6, 2026 - Jun 10, 2026 |
| #11 | -5.55% Jun 23, 2026 - Jun 26, 2026 | -14.88% Oct 20, 2017 - Jun 6, 2018 |
| #12 | -4.76% Oct 31, 2024 - Nov 4, 2024 | -12.23% Jan 29, 2024 - Jul 11, 2024 |
| #13 | -3.65% Jun 18, 2026 - Jun 23, 2026 | -11.35% Jul 31, 2003 - Oct 24, 2003 |
| #14 | -3.57% May 28, 2026 - Jun 4, 2026 | -10.72% Nov 5, 2021 - Jan 10, 2022 |
| #15 | -3.45% Nov 4, 2024 - Nov 6, 2024 | -10.60% Jul 17, 2015 - Oct 21, 2015 |
Correlation
Correlation between SEPN and QCRH is 0.89 which considered as a strong positive correlation - the stocks tend to move together.
0.89
-101
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