SEPN vs JXN-P-A

Comparison between Septerna Inc (SEPN, Company) and Jackson Financial Inc (JXN-P-A, Company).

SEPN vs JXN-P-A - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SEPN(COMPANY)	JXN-P-A(COMPANY)
Market Cap	$1.74B	$1.74B
Max Drawdown	81.47%	9.27%
Sharpe Ratio	2.10	0.13
5Y Beta	1.27	0.14
Industry	Biotechnology	N/A
P/E Ratio	-48.08	15.67
Forward P/E	107.53	N/A
PEG Ratio	N/A	0.10
Debt to Equity	0.00%	27.80%
Free Cash Flow Yield	6.14%	N/A
P/S Ratio	24.18	N/A
P/B Ratio	4.11	N/A

Market Cap

SEPN

$1.74B

Winner

JXN-P-A

$1.74B

Max Drawdown

SEPN

81.47%

Winner

JXN-P-A

9.27%

Sharpe Ratio

Winner

SEPN

2.10

JXN-P-A

0.13

5Y Beta

SEPN

1.27

Winner

JXN-P-A

0.14

Industry

SEPN

Biotechnology

JXN-P-A

N/A

P/E Ratio

Winner

SEPN

-48.08

JXN-P-A

15.67

Forward P/E

SEPN

107.53

JXN-P-A

N/A

PEG Ratio

SEPN

N/A

JXN-P-A

0.10

Debt to Equity

Winner

SEPN

0.00%

JXN-P-A

27.80%

Free Cash Flow Yield

SEPN

6.14%

JXN-P-A

N/A

P/S Ratio

SEPN

24.18

JXN-P-A

N/A

P/B Ratio

SEPN

4.11

JXN-P-A

N/A

SEPN vs JXN-P-A - Historical Returns

Returns include dividend reinvestment.

Period	SEPN	JXN-P-A
1 month	+8.37%	+0.08%
3 months	+61.93%	-0.35%
6 months	+52.81%	+0.93%
1 year	+231.88%	+4.35%
Max(CAGR)	+39.69%	+13.41%

Winner

SEPN

+8.37%

JXN-P-A

+0.08%

Winner

SEPN

+61.93%

JXN-P-A

-0.35%

Winner

SEPN

+52.81%

JXN-P-A

+0.93%

Winner

SEPN

+231.88%

JXN-P-A

+4.35%

Max(CAGR)

Winner

SEPN

+39.69%

JXN-P-A

+13.41%

SEPN vs JXN-P-A - Annual Returns (2023 - 2026)

Returns include dividend reinvestment.

Year	SEPN	JXN-P-A
2026	+38.78%	+1.05%
2025	+30.59%	+6.49%
2024	+7.01%	+11.60%
2023	N/A	+25.09%

SEPN vs JXN-P-A Drawdown Comparison

The maximum drawdown for SEPN was -81.47%, occurring on Apr 1, 2025. Recovery took 230 trading sessions.

The maximum drawdown for JXN-P-A was -6.15%, occurring on Oct 27, 2023. Recovery took 42 trading sessions.

The current SEPN drawdown is -1.77%. The current JXN-P-A drawdown is -2.22%.

Rank	SEPN	JXN-P-A
#1	-81.47% Dec 23, 2024 - Nov 24, 2025	-6.15% Sep 19, 2023 - Nov 16, 2023
#2	-25.18% Feb 24, 2026 - May 28, 2026	-6.13% Apr 27, 2023 - May 26, 2023
#3	-21.10% Dec 19, 2025 - Feb 17, 2026	-5.86% Feb 23, 2024 - Aug 16, 2024
#4	-16.77% Dec 4, 2024 - Dec 23, 2024	-4.29% Nov 29, 2024 - Jul 24, 2025
#5	-16.60% Jul 9, 2026 - Aug 4, 2026	-3.64% Jan 29, 2024 - Feb 22, 2024
#6	-16.19% Nov 7, 2024 - Dec 4, 2024	-3.47% Jan 26, 2026 - Apr 16, 2026
#7	-13.97% Nov 26, 2025 - Dec 19, 2025	-3.33% Jun 17, 2026 - Jun 30, 2026
#8	-10.63% Feb 17, 2026 - Feb 24, 2026	-2.72% Sep 29, 2025 - Dec 5, 2025
#9	-10.36% Jun 26, 2026 - Jul 9, 2026	-2.38% Mar 31, 2023 - Apr 11, 2023
#10	-6.45% Oct 25, 2024 - Oct 31, 2024	-2.36% May 1, 2026 - Jun 15, 2026
#11	-5.55% Jun 23, 2026 - Jun 26, 2026	-2.26% Nov 8, 2024 - Nov 29, 2024
#12	-4.76% Oct 31, 2024 - Nov 4, 2024	-2.19% Mar 22, 2023 - Mar 27, 2023
#13	-3.65% Jun 18, 2026 - Jun 23, 2026	-1.97% Aug 8, 2025 - Sep 15, 2025
#14	-3.57% May 28, 2026 - Jun 4, 2026	-1.67% Jun 2, 2023 - Jun 21, 2023
#15	-3.45% Nov 4, 2024 - Nov 6, 2024	-1.64% Dec 26, 2023 - Jan 10, 2024