SEPN vs INSP

Comparison between Septerna Inc (SEPN, Company) and Inspire Medical Systems Inc (INSP, Company).

Both SEPN and INSP are from the Healthcare sector.

SEPN vs INSP - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SEPN(COMPANY)	INSP(COMPANY)
Market Cap	$1.74B	$1.74B
Max Drawdown	81.47%	87.72%
Sharpe Ratio	2.10	-0.08
5Y Beta	1.27	1.07
Industry	Biotechnology	Medical Devices
P/E Ratio	-48.08	12.72
Forward P/E	107.53	114.94
PEG Ratio	N/A	0.08
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	6.14%	6.74%
P/S Ratio	24.18	1.89
P/B Ratio	4.11	1.83

Market Cap

Winner

SEPN

$1.74B

INSP

$1.74B

Max Drawdown

Winner

SEPN

81.47%

INSP

87.72%

Sharpe Ratio

Winner

SEPN

2.10

INSP

-0.08

5Y Beta

SEPN

1.27

Winner

INSP

1.07

Industry

SEPN

Biotechnology

INSP

Medical Devices

P/E Ratio

Winner

SEPN

-48.08

INSP

12.72

Forward P/E

Winner

SEPN

107.53

INSP

114.94

PEG Ratio

SEPN

N/A

INSP

0.08

Debt to Equity

SEPN

0.00%

INSP

0.00%

Free Cash Flow Yield

SEPN

6.14%

Winner

INSP

6.74%

P/S Ratio

SEPN

24.18

Winner

INSP

1.89

P/B Ratio

SEPN

4.11

Winner

INSP

1.83

SEPN vs INSP - Historical Returns

Returns include dividend reinvestment.

Period	SEPN	INSP
1 month	+8.37%	+20.13%
3 months	+61.93%	+32.02%
6 months	+52.81%	-8.43%
1 year	+231.88%	-21.92%
5 years(CAGR)	N/A	-22.39%
10 years(CAGR)	N/A	+11.22%
Max(CAGR)	+39.69%	+11.22%

SEPN

+8.37%

Winner

INSP

+20.13%

Winner

SEPN

+61.93%

INSP

+32.02%

Winner

SEPN

+52.81%

INSP

-8.43%

Winner

SEPN

+231.88%

INSP

-21.92%

5Y(CAGR)

SEPN

N/A

INSP

-22.39%

10Y(CAGR)

SEPN

N/A

INSP

+11.22%

Max(CAGR)

Winner

SEPN

+39.69%

INSP

+11.22%

SEPN vs INSP - Annual Returns (2018 - 2026)

Returns include dividend reinvestment.

Year	SEPN	INSP
2026	+38.78%	-34.80%
2025	+30.59%	-51.25%
2024	+7.01%	-1.31%
2023	N/A	-19.59%
2022	N/A	+5.85%
2021	N/A	+26.09%
2020	N/A	+152.50%
2019	N/A	+80.08%
2018	N/A	+69.14%

SEPN vs INSP Drawdown Comparison

The maximum drawdown for SEPN was -81.47%, occurring on Apr 1, 2025. Recovery took 230 trading sessions.

The maximum drawdown for INSP was -87.72%, occurring on May 15, 2026. This drawdown has not yet recovered.

The current SEPN drawdown is -1.77%. The current INSP drawdown is -81.55%.

Rank	SEPN	INSP
#1	-81.47% Dec 23, 2024 - Nov 24, 2025	-87.72% Jul 14, 2023 - May 15, 2026
#2	-25.18% Feb 24, 2026 - May 28, 2026	-53.71% Mar 2, 2020 - Jun 17, 2020
#3	-21.10% Dec 19, 2025 - Feb 17, 2026	-47.34% Nov 8, 2021 - May 8, 2023
#4	-16.77% Dec 4, 2024 - Dec 23, 2024	-34.95% Sep 4, 2018 - Feb 8, 2019
#5	-16.60% Jul 9, 2026 - Aug 4, 2026	-33.83% Mar 1, 2021 - Sep 17, 2021
#6	-16.19% Nov 7, 2024 - Dec 4, 2024	-25.74% Aug 29, 2019 - Nov 26, 2019
#7	-13.97% Nov 26, 2025 - Dec 19, 2025	-24.08% Feb 28, 2019 - Jul 1, 2019
#8	-10.63% Feb 17, 2026 - Feb 24, 2026	-16.01% May 18, 2018 - Jun 8, 2018
#9	-10.36% Jun 26, 2026 - Jul 9, 2026	-15.52% Jan 19, 2021 - Feb 9, 2021
#10	-6.45% Oct 25, 2024 - Oct 31, 2024	-13.71% Jun 23, 2020 - Jul 15, 2020
#11	-5.55% Jun 23, 2026 - Jun 26, 2026	-13.33% Sep 21, 2021 - Oct 22, 2021
#12	-4.76% Oct 31, 2024 - Nov 4, 2024	-10.79% Oct 7, 2020 - Nov 3, 2020
#13	-3.65% Jun 18, 2026 - Jun 23, 2026	-9.72% Jun 22, 2018 - Jul 10, 2018
#14	-3.57% May 28, 2026 - Jun 4, 2026	-9.30% Jan 17, 2020 - Feb 26, 2020
#15	-3.45% Nov 4, 2024 - Nov 6, 2024	-9.06% Jul 15, 2019 - Aug 29, 2019

Correlation

Correlation between SEPN and INSP is -0.56 which considered as a moderate negative correlation - the stocks show some tendency to move in opposite directions.

-0.56

-101