SEPN vs BMEZ

Comparison between Septerna Inc (SEPN, Company) and BlackRock Health Sciences Term Trust (BMEZ, Company).

SEPN is from the Healthcare sector, while BMEZ is from the Financial Services sector.

SEPN vs BMEZ - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SEPN(COMPANY)	BMEZ(COMPANY)
Market Cap	$1.53B	$1.53B
Max Drawdown	81.47%	57.56%
Sharpe Ratio	1.78	0.97
5Y Beta	1.24	0.59
Industry	Biotechnology	Asset Management
P/E Ratio	-42.26	5.72
Forward P/E	107.53	N/A
5Y Dividends CAGR	N/A	2.28%
Debt to Equity	0.00%	N/A
Free Cash Flow Yield	6.99%	N/A
P/S Ratio	21.25	23.44
P/B Ratio	4.11	0.98

Market Cap

Winner

SEPN

$1.53B

BMEZ

$1.53B

Max Drawdown

SEPN

81.47%

Winner

BMEZ

57.56%

Sharpe Ratio

Winner

SEPN

1.78

BMEZ

0.97

5Y Beta

SEPN

1.24

Winner

BMEZ

0.59

Industry

SEPN

Biotechnology

BMEZ

Asset Management

P/E Ratio

Winner

SEPN

-42.26

BMEZ

5.72

Forward P/E

SEPN

107.53

BMEZ

N/A

5Y Dividends CAGR

SEPN

N/A

BMEZ

2.28%

Debt to Equity

SEPN

0.00%

BMEZ

N/A

Free Cash Flow Yield

SEPN

6.99%

BMEZ

N/A

P/S Ratio

Winner

SEPN

21.25

BMEZ

23.44

P/B Ratio

SEPN

4.11

Winner

BMEZ

0.98

SEPN vs BMEZ - Historical Returns

Returns include dividend reinvestment.

Period	SEPN	BMEZ
1 month	-3.36%	+5.48%
3 months	+30.54%	+8.54%
6 months	+27.82%	+2.82%
1 year	+173.60%	+20.78%
5 years(CAGR)	N/A	-2.05%
Max(CAGR)	+29.86%	+5.08%

SEPN

-3.36%

Winner

BMEZ

+5.48%

Winner

SEPN

+30.54%

BMEZ

+8.54%

Winner

SEPN

+27.82%

BMEZ

+2.82%

Winner

SEPN

+173.60%

BMEZ

+20.78%

5Y(CAGR)

SEPN

N/A

BMEZ

-2.05%

Max(CAGR)

Winner

SEPN

+29.86%

BMEZ

+5.08%

SEPN vs BMEZ - Annual Returns (2020 - 2026)

Returns include dividend reinvestment.

Year	SEPN	BMEZ
2026	+20.37%	+7.21%
2025	+30.59%	+18.07%
2024	+7.01%	+9.18%
2023	N/A	+3.31%
2022	N/A	-33.22%
2021	N/A	-7.99%
2020	N/A	+48.75%

SEPN vs BMEZ Drawdown Comparison

The maximum drawdown for SEPN was -81.47%, occurring on Apr 1, 2025. Recovery took 230 trading sessions.

The maximum drawdown for BMEZ was -46.18%, occurring on May 11, 2022. This drawdown has not yet recovered.

The current SEPN drawdown is -10.99%. The current BMEZ drawdown is -14.06%.

Rank	SEPN	BMEZ
#1	-81.47% Dec 23, 2024 - Nov 24, 2025	-46.18% Feb 12, 2021 - May 11, 2022
#2	-25.18% Feb 24, 2026 - May 28, 2026	-39.45% Feb 11, 2020 - Jul 6, 2020
#3	-21.10% Dec 19, 2025 - Feb 17, 2026	-9.99% Sep 1, 2020 - Oct 5, 2020
#4	-16.77% Dec 4, 2024 - Dec 23, 2024	-8.45% Oct 13, 2020 - Nov 5, 2020
#5	-16.60% Jul 9, 2026 - Jul 16, 2026	-8.29% Jan 20, 2021 - Feb 12, 2021
#6	-16.19% Nov 7, 2024 - Dec 4, 2024	-5.64% Dec 23, 2020 - Jan 14, 2021
#7	-13.97% Nov 26, 2025 - Dec 19, 2025	-4.23% Aug 7, 2020 - Aug 31, 2020
#8	-10.63% Feb 17, 2026 - Feb 24, 2026	-3.53% Nov 17, 2020 - Nov 25, 2020
#9	-10.36% Jun 26, 2026 - Jul 9, 2026	-2.49% Dec 2, 2020 - Dec 9, 2020
#10	-6.45% Oct 25, 2024 - Oct 31, 2024	-2.23% Jul 17, 2020 - Jul 28, 2020
#11	-5.55% Jun 23, 2026 - Jun 26, 2026	-2.04% Jul 29, 2020 - Aug 5, 2020
#12	-4.76% Oct 31, 2024 - Nov 4, 2024	-1.88% Jan 14, 2021 - Jan 20, 2021
#13	-3.65% Jun 18, 2026 - Jun 23, 2026	-1.82% Oct 7, 2020 - Oct 13, 2020
#14	-3.57% May 28, 2026 - Jun 4, 2026	-1.55% Dec 15, 2020 - Dec 22, 2020
#15	-3.45% Nov 4, 2024 - Nov 6, 2024	-1.36% Nov 6, 2020 - Nov 11, 2020