SEPN vs AMC

Comparison between Septerna Inc (SEPN, Company) and AMC Entertainment Holdings Inc - Class A (AMC, Company).

SEPN is from the Healthcare sector, while AMC is from the Communication Services sector.

SEPN vs AMC - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SEPN(COMPANY)	AMC(COMPANY)
Market Cap	$1.53B	$1.53B
Max Drawdown	81.47%	99.85%
Sharpe Ratio	1.78	-0.24
5Y Beta	1.24	1.12
Industry	Biotechnology	Entertainment
P/E Ratio	-42.26	-2.21
Forward P/E	107.53	121.95
PEG Ratio	N/A	-0.03
5Y Dividends CAGR	N/A	-58.37%
5Y EPS CAGR	N/A	-1.80%
Debt to Equity	0.00%	-205.76%
Free Cash Flow Yield	6.99%	7.97%
P/S Ratio	21.25	0.42
P/B Ratio	4.11	0.18

Market Cap

Winner

SEPN

$1.53B

AMC

$1.53B

Max Drawdown

Winner

SEPN

81.47%

AMC

99.85%

Sharpe Ratio

Winner

SEPN

1.78

AMC

-0.24

5Y Beta

SEPN

1.24

Winner

AMC

1.12

Industry

SEPN

Biotechnology

AMC

Entertainment

P/E Ratio

Winner

SEPN

-42.26

AMC

-2.21

Forward P/E

Winner

SEPN

107.53

AMC

121.95

PEG Ratio

SEPN

N/A

AMC

-0.03

5Y Dividends CAGR

SEPN

N/A

AMC

-58.37%

5Y EPS CAGR

SEPN

N/A

AMC

-1.80%

Debt to Equity

SEPN

0.00%

Winner

AMC

-205.76%

Free Cash Flow Yield

SEPN

6.99%

Winner

AMC

7.97%

P/S Ratio

SEPN

21.25

Winner

AMC

0.42

P/B Ratio

SEPN

4.11

Winner

AMC

0.18

SEPN vs AMC - Historical Returns

Returns include dividend reinvestment.

Period	SEPN	AMC
1 month	-3.36%	-19.57%
3 months	+30.54%	+32.93%
6 months	+27.82%	+37.89%
1 year	+173.60%	-35.47%
5 years(CAGR)	N/A	-64.75%
10 years(CAGR)	N/A	-37.18%
Max(CAGR)	+29.86%	-27.89%

Winner

SEPN

-3.36%

AMC

-19.57%

SEPN

+30.54%

Winner

AMC

+32.93%

SEPN

+27.82%

Winner

AMC

+37.89%

Winner

SEPN

+173.60%

AMC

-35.47%

5Y(CAGR)

SEPN

N/A

AMC

-64.75%

10Y(CAGR)

SEPN

N/A

AMC

-37.18%

Max(CAGR)

Winner

SEPN

+29.86%

AMC

-27.89%

SEPN vs AMC - Annual Returns (2013 - 2026)

Returns include dividend reinvestment.

Year	SEPN	AMC
2026	+20.37%	+37.89%
2025	+30.59%	-61.19%
2024	+7.01%	-34.86%
2023	N/A	-84.43%
2022	N/A	-84.65%
2021	N/A	+1253.23%
2020	N/A	-71.39%
2019	N/A	-39.56%
2018	N/A	-9.77%
2017	N/A	-54.58%
2016	N/A	+49.22%
2015	N/A	-3.69%
2014	N/A	+33.01%
2013	N/A	+8.73%

SEPN vs AMC Drawdown Comparison

The maximum drawdown for SEPN was -81.47%, occurring on Apr 1, 2025. Recovery took 230 trading sessions.

The maximum drawdown for AMC was -99.85%, occurring on Mar 27, 2026. This drawdown has not yet recovered.

The current SEPN drawdown is -10.99%. The current AMC drawdown is -99.64%.

Rank	SEPN	AMC
#1	-81.47% Dec 23, 2024 - Nov 24, 2025	-99.85% Jun 2, 2021 - Mar 27, 2026
#2	-25.18% Feb 24, 2026 - May 28, 2026	-92.84% Dec 27, 2016 - Jun 1, 2021
#3	-21.10% Dec 19, 2025 - Feb 17, 2026	-42.79% Mar 23, 2015 - Nov 11, 2016
#4	-16.77% Dec 4, 2024 - Dec 23, 2024	-17.00% Mar 7, 2014 - Oct 29, 2014
#5	-16.60% Jul 9, 2026 - Jul 16, 2026	-10.03% Nov 17, 2016 - Dec 23, 2016
#6	-16.19% Nov 7, 2024 - Dec 4, 2024	-7.72% Dec 1, 2014 - Dec 22, 2014
#7	-13.97% Nov 26, 2025 - Dec 19, 2025	-6.90% Dec 23, 2014 - Jan 9, 2015
#8	-10.63% Feb 17, 2026 - Feb 24, 2026	-4.06% Jan 28, 2014 - Feb 12, 2014
#9	-10.36% Jun 26, 2026 - Jul 9, 2026	-3.93% Oct 30, 2014 - Nov 7, 2014
#10	-6.45% Oct 25, 2024 - Oct 31, 2024	-3.54% Mar 2, 2015 - Mar 16, 2015
#11	-5.55% Jun 23, 2026 - Jun 26, 2026	-3.17% Nov 11, 2014 - Nov 24, 2014
#12	-4.76% Oct 31, 2024 - Nov 4, 2024	-3.13% Jan 27, 2015 - Feb 3, 2015
#13	-3.65% Jun 18, 2026 - Jun 23, 2026	-2.87% Dec 31, 2013 - Jan 21, 2014
#14	-3.57% May 28, 2026 - Jun 4, 2026	-1.82% Jan 12, 2015 - Jan 22, 2015
#15	-3.45% Nov 4, 2024 - Nov 6, 2024	-1.06% Dec 23, 2013 - Dec 26, 2013

Correlation

Correlation between SEPN and AMC is -0.38 which considered as a weak negative correlation - the stocks show a slight tendency to move in opposite directions.

-0.38

-101