SBIO vs SPWO
Comparison between ALPS MEDICAL BREAKTHROUGHS ETF (SBIO, ETF) and SP FUNDS S&P WORLD (EX-US) ETF (SPWO, ETF).
SBIO vs SPWO - Performance Comparison
Key Characteristics
Financial metrics and valuation ratios
Net Assets
SBIO
$156M
Winner
SPWO
$156M
Expense Ratio
Winner
SBIO
0.50%
SPWO
0.55%
Max Drawdown
SBIO
63.06%
Winner
SPWO
18.57%
Sharpe Ratio
Winner
SBIO
1.69
SPWO
1.55
5Y Beta
SBIO
1.03
Winner
SPWO
0.90
P/E Ratio
SBIO
-13.78
SPWO
N/A
5Y Dividends CAGR
SBIO
9.24%
SPWO
N/A
Debt to Equity
SBIO
4.92%
SPWO
N/A
P/S Ratio
SBIO
7.34
SPWO
N/A
P/B Ratio
SBIO
4.16
SPWO
N/A
SBIO vs SPWO - Holdings Comparison
SBIO and SPWO have 1 common holdings. Overlap is -0.39%
SBIO's top 25 holdings weight is 63.20%. SPWO's top 25 holdings weight is 53.84%.
| Rank | SBIO | SPWO |
|---|---|---|
| #1 | KYMERA THERAPEUTICS INC ORDINARY SHARES (KYMR) - 4.26% | n/a (TSM) - 19.17% |
| #2 | ALKERMES PLC (ALKS) - 4.02% | SAMSUNG ELECTRONICS CO LTD (n/a) - 4.74% |
| #3 | CELCUITY INC (CELC) - 4.01% | SK HYNIX INC (n/a) - 3.57% |
| #4 | MIRUM PHARMACEUTICALS INC (MIRM) - 3.86% | ALIBABA GROUP HOLDING LTD ADR (BABA) - 3.15% |
| #5 | SPYRE THERAPEUTICS INC (SYRE) - 3.74% | ASML HOLDING NV (n/a) - 3.02% |
| #6 | CG ONCOLOGY INC (CGON) - 3.38% | MEDIATEK INC (n/a) - 2.38% |
| #7 | APOGEE THERAPEUTICS INC (APGE) - 3.00% | DELTA ELECTRONICS INC (n/a) - 1.58% |
| #8 | XENON PHARMACEUTICALS INC (XENE) - 2.90% | ROCHE HOLDING AG ADR (RHHBY) - 1.43% |
| #9 | NEWAMSTERDAM PHARMA CO NV (NAMS) - 2.68% | NOVARTIS AG ADR (NVS) - 1.40% |
| #10 | TRAVERE THERAPEUTICS INC ORDINARY SHARES (TVTX) - 2.64% | ASTRAZENECA PLC (AZN:XLON) - 1.40% |
| #11 | CRINETICS PHARMACEUTICALS INC (CRNX) - 2.49% | NESTLE SA ADR (NSRGY) - 1.26% |
| #12 | DIANTHUS THERAPEUTICS INC (DNTH) - 2.49% | BHP GROUP LTD ADR (BHP) - 1.05% |
| #13 | ACADIA PHARMACEUTICALS INC (ACAD) - 2.34% | OTHER ASSETS AND LIABILITIES (n/a) - 0.96% |
| #14 | EDGEWISE THERAPEUTICS INC (EWTX) - 2.33% | SAP SE ADR (SAP) - 0.87% |
| #15 | VIKING THERAPEUTICS INC (VKTX) - 2.30% | PDD HOLDINGS INC ADR (PDD) - 0.83% |
| #16 | DENALI THERAPEUTICS INC (DNLI) - 1.99% | SCHNEIDER ELECTRIC SE ADR (SBGSY) - 0.83% |
| #17 | ORUKA THERAPEUTICS INC (ORKA) - 1.85% | ABB LTD (n/a) - 0.81% |
| #18 | STRUCTURE THERAPEUTICS INC ADR (GPCR) - 1.81% | TOKYO ELECTRON LTD ADR (TOELY) - 0.75% |
| #19 | n/a (TARS) - 1.68% | SIEMENS ENERGY AG ADR SPONSORED (SMERY) - 0.75% |
| #20 | DISC MEDICINE INC ORDINARY SHARES (IRON) - 1.68% | XIAOMI CORP ADR (XIACY) - 0.72% |
| #21 | IDEAYA BIOSCIENCES INC (IDYA) - 1.67% | HITACHI LTD ADR (HTHIY) - 0.71% |
| #22 | RELAY THERAPEUTICS INC ORDINARY SHARES (RLAY) - 1.64% | NOVO NORDISK AS ADR (NVO) - 0.66% |
| #23 | VERA THERAPEUTICS INC CLASS A (VERA) - 1.58% | ELITE MATERIAL CO LTD (n/a) - 0.60% |
| #24 | MINERALYS THERAPEUTICS INC (MLYS) - 1.53% | UNILEVER PLC ADR (UL) - 0.60% |
| #25 | CELLDEX THERAPEUTICS INC (CLDX) - 1.33% | ADVANTEST CORP ADR (ATEYY) - 0.60% |
| Total Holdings | 86 | 389 |
SBIO vs SPWO - Historical Returns
Returns include dividend reinvestment.
1M
SBIO
-8.63%
Winner
SPWO
+2.11%
3M
SBIO
+2.25%
Winner
SPWO
+12.16%
6M
SBIO
+0.14%
Winner
SPWO
+20.96%
1Y
Winner
SBIO
+62.88%
SPWO
+38.72%
5Y(CAGR)
SBIO
+2.48%
SPWO
N/A
10Y(CAGR)
SBIO
+7.68%
SPWO
N/A
Max(CAGR)
SBIO
+7.19%
Winner
SPWO
+24.16%
SBIO vs SPWO - Annual Returns (2014 - 2026)
Returns include dividend reinvestment.
| Year | SBIO | SPWO |
|---|---|---|
| 2026 | +0.72% | +17.06% |
| 2025 | +53.69% | +26.79% |
| 2024 | +4.25% | +10.96% |
| 2023 | +11.05% | +2.96% |
| 2022 | -30.19% | N/A |
| 2021 | -17.90% | N/A |
| 2020 | +23.09% | N/A |
| 2019 | +47.58% | N/A |
| 2018 | -13.24% | N/A |
| 2017 | +44.12% | N/A |
| 2016 | -25.20% | N/A |
| 2015 | +26.42% | N/A |
| 2014 | +0.00% | N/A |
SBIO vs SPWO Drawdown Comparison
The maximum drawdown for SBIO was -63.06%, occurring on Oct 27, 2023. This drawdown has not yet recovered.
The maximum drawdown for SPWO was -18.02%, occurring on Apr 8, 2025. Recovery took 164 trading sessions.
The current SBIO drawdown is -17.62%. The current SPWO drawdown is -6.70%.
| Rank | SBIO | SPWO |
|---|---|---|
| #1 | -63.06% Feb 8, 2021 - Oct 27, 2023 | -18.02% Oct 7, 2024 - Jun 4, 2025 |
| #2 | -49.69% Jul 17, 2015 - Jun 6, 2018 | -13.75% Feb 25, 2026 - Apr 24, 2026 |
| #3 | -39.30% Dec 24, 2019 - Jun 23, 2020 | -9.89% Jul 12, 2024 - Sep 24, 2024 |
| #4 | -32.42% Sep 28, 2018 - Nov 25, 2019 | -6.75% Oct 6, 2025 - Jan 2, 2026 |
| #5 | -13.78% Apr 23, 2015 - May 20, 2015 | -6.70% Jun 2, 2026 - Jun 5, 2026 |
| #6 | -13.03% Jun 23, 2020 - Oct 7, 2020 | -6.32% Mar 7, 2024 - May 7, 2024 |
| #7 | -11.31% Mar 19, 2015 - Apr 13, 2015 | -4.78% Jul 23, 2025 - Sep 8, 2025 |
| #8 | -6.72% Jun 6, 2018 - Sep 28, 2018 | -4.24% May 11, 2026 - May 26, 2026 |
| #9 | -6.30% Jan 27, 2015 - Feb 17, 2015 | -4.00% Dec 29, 2023 - Feb 8, 2024 |
| #10 | -6.29% Jun 22, 2015 - Jul 13, 2015 | -3.83% Jun 12, 2025 - Jun 27, 2025 |
| #11 | -6.19% Dec 22, 2020 - Jan 7, 2021 | -3.39% Jan 27, 2026 - Feb 9, 2026 |
| #12 | -4.88% Oct 13, 2020 - Oct 27, 2020 | -3.17% May 22, 2024 - Jul 5, 2024 |
| #13 | -3.81% Jan 14, 2015 - Jan 20, 2015 | -2.23% Feb 9, 2024 - Feb 15, 2024 |
| #14 | -3.39% Oct 27, 2020 - Nov 4, 2020 | -2.09% Jan 15, 2026 - Jan 22, 2026 |
| #15 | -3.31% Jan 26, 2021 - Feb 1, 2021 | -2.09% Apr 27, 2026 - Apr 30, 2026 |
Correlation
Correlation between SBIO and SPWO is 0.89 which considered as a strong positive correlation - the stocks tend to move together.
0.89
-101
Dividend Comparison (2017 - 2026)
SBIO vs SPWO dividend yield comparison.
| Year | SBIO | SPWO |
|---|---|---|
| 2026 | 0.00% | 0.39% |
| 2025 | 0.00% | 1.29% |
| 2024 | 3.55% | 1.24% |
| 2023 | 0.22% | 0.00% |
| 2019 | 0.04% | 0.00% |
| 2018 | 2.79% | 0.00% |
| 2017 | 1.77% | 0.00% |
Select Stocks to Compare
Popular: SBIO vs SPYSPWO vs SPY
More Comparisons
Compare with similar stocks