SBIO vs CWS

Comparison between ALPS MEDICAL BREAKTHROUGHS ETF (SBIO, ETF) and ADVISORSHARES FOCUSED EQUITY ETF (CWS, ETF).

5-Year PerformanceCWS has outperformed SBIO, delivering a return of +8.2% compared to +2.5%

SBIO vs CWS - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SBIO(ETF)	CWS(ETF)
Net Assets	$156M	$155M
Expense Ratio	0.50%	0.65%
Max Drawdown	63.06%	33.82%
Sharpe Ratio	1.69	-0.23
5Y Beta	1.03	0.67
P/E Ratio	-13.78	23.89
Forward P/E	N/A	19.86
PEG Ratio	N/A	0.73
5Y Dividends CAGR	9.24%	32.22%
5Y EPS CAGR	N/A	24.14%
Debt to Equity	4.92%	45.97%
P/S Ratio	7.34	1.34
P/B Ratio	4.16	5.55

Net Assets

Winner

SBIO

$156M

CWS

$155M

Expense Ratio

Winner

SBIO

0.50%

CWS

0.65%

Max Drawdown

SBIO

63.06%

Winner

CWS

33.82%

Sharpe Ratio

Winner

SBIO

1.69

CWS

-0.23

5Y Beta

SBIO

1.03

Winner

CWS

0.67

P/E Ratio

Winner

SBIO

-13.78

CWS

23.89

Forward P/E

SBIO

N/A

CWS

19.86

PEG Ratio

SBIO

N/A

CWS

0.73

5Y Dividends CAGR

SBIO

9.24%

Winner

CWS

32.22%

5Y EPS CAGR

SBIO

N/A

CWS

24.14%

Debt to Equity

Winner

SBIO

4.92%

CWS

45.97%

P/S Ratio

SBIO

7.34

Winner

CWS

1.34

P/B Ratio

Winner

SBIO

4.16

CWS

5.55

SBIO vs CWS - Holdings Comparison

SBIO and CWS have 1 common holdings. Overlap is 0.00%

SBIO's top 25 holdings weight is 63.20%. CWS's top 25 holdings weight is 99.70%.

Rank	SBIO	CWS
#1	KYMERA THERAPEUTICS INC ORDINARY SHARES (KYMR) - 4.26%	COMFORT SYSTEMS USA INC (FIX) - 8.20%
#2	ALKERMES PLC (ALKS) - 4.02%	IES HOLDINGS INC (IESC) - 7.15%
#3	CELCUITY INC (CELC) - 4.01%	CASEY'S GENERAL STORES INC (CASY) - 5.89%
#4	MIRUM PHARMACEUTICALS INC (MIRM) - 3.86%	MUELLER INDUSTRIES INC (MLI) - 4.82%
#5	SPYRE THERAPEUTICS INC (SYRE) - 3.74%	ALLISON TRANSMISSION HOLDINGS INC (ALSN) - 4.67%
#6	CG ONCOLOGY INC (CGON) - 3.38%	SPROUTS FARMERS MARKET INC (SFM) - 4.41%
#7	APOGEE THERAPEUTICS INC (APGE) - 3.00%	AMPHENOL CORP CLASS A (APH) - 4.19%
#8	XENON PHARMACEUTICALS INC (XENE) - 2.90%	SCIENCE APPLICATIONS INTERNATIONAL CORP (SAIC) - 4.05%
#9	NEWAMSTERDAM PHARMA CO NV (NAMS) - 2.68%	HENRY SCHEIN INC (HSIC) - 3.96%
#10	TRAVERE THERAPEUTICS INC ORDINARY SHARES (TVTX) - 2.64%	AMERICAN WATER WORKS CO INC (AWK) - 3.84%
#11	CRINETICS PHARMACEUTICALS INC (CRNX) - 2.49%	HEICO CORP (HEI) - 3.82%
#12	DIANTHUS THERAPEUTICS INC (DNTH) - 2.49%	INTERCONTINENTAL EXCHANGE INC (ICE) - 3.78%
#13	ACADIA PHARMACEUTICALS INC (ACAD) - 2.34%	MCKESSON CORP (MCK) - 3.74%
#14	EDGEWISE THERAPEUTICS INC (EWTX) - 2.33%	MOODYS CORP (MCO) - 3.68%
#15	VIKING THERAPEUTICS INC (VKTX) - 2.30%	STRYKER CORP (SYK) - 3.62%
#16	DENALI THERAPEUTICS INC (DNLI) - 1.99%	ROLLINS INC (ROL) - 3.59%
#17	ORUKA THERAPEUTICS INC (ORKA) - 1.85%	RESMED INC (RMD) - 3.50%
#18	STRUCTURE THERAPEUTICS INC ADR (GPCR) - 1.81%	CENCORA INC (COR) - 3.26%
#19	n/a (TARS) - 1.68%	FACTSET RESEARCH SYSTEMS INC (FDS) - 3.25%
#20	DISC MEDICINE INC ORDINARY SHARES (IRON) - 1.68%	THERMO FISHER SCIENTIFIC INC (TMO) - 3.17%
#21	IDEAYA BIOSCIENCES INC (IDYA) - 1.67%	FAIR ISAAC CORP (FICO) - 2.98%
#22	RELAY THERAPEUTICS INC ORDINARY SHARES (RLAY) - 1.64%	ABBOTT LABORATORIES (ABT) - 2.84%
#23	VERA THERAPEUTICS INC CLASS A (VERA) - 1.58%	ADOBE INC (ADBE) - 2.80%
#24	MINERALYS THERAPEUTICS INC (MLYS) - 1.53%	BROADRIDGE FINANCIAL SOLUTIONS INC (BR) - 2.64%
#25	CELLDEX THERAPEUTICS INC (CLDX) - 1.33%	INTUIT INC (INTU) - 1.85%
Total Holdings	86	26

SBIO vs CWS - Historical Returns

Returns include dividend reinvestment.

Period	SBIO	CWS
1 month	-8.63%	-0.65%
3 months	+2.25%	-1.14%
6 months	+0.14%	-2.17%
1 year	+62.88%	-0.29%
5 years(CAGR)	+2.48%	+8.25%
10 years(CAGR)	+7.68%	+11.28%
Max(CAGR)	+7.19%	+11.28%

SBIO

-8.63%

Winner

CWS

-0.65%

Winner

SBIO

+2.25%

CWS

-1.14%

Winner

SBIO

+0.14%

CWS

-2.17%

Winner

SBIO

+62.88%

CWS

-0.29%

5Y(CAGR)

SBIO

+2.48%

Winner

CWS

+8.25%

10Y(CAGR)

SBIO

+7.68%

Winner

CWS

+11.28%

Max(CAGR)

SBIO

+7.19%

Winner

CWS

+11.28%

SBIO vs CWS - Annual Returns (2014 - 2026)

Returns include dividend reinvestment.

Year	SBIO	CWS
2026	+0.72%	-1.46%
2025	+53.69%	+6.52%
2024	+4.25%	+10.75%
2023	+11.05%	+24.69%
2022	-30.19%	-8.78%
2021	-17.90%	+23.04%
2020	+23.09%	+17.50%
2019	+47.58%	+30.28%
2018	-13.24%	-6.53%
2017	+44.12%	+19.95%
2016	-25.20%	+3.01%
2015	+26.42%	N/A
2014	+0.00%	N/A

SBIO vs CWS Drawdown Comparison

The maximum drawdown for SBIO was -63.06%, occurring on Oct 27, 2023. This drawdown has not yet recovered.

The maximum drawdown for CWS was -33.82%, occurring on Mar 23, 2020. Recovery took 122 trading sessions.

The current SBIO drawdown is -17.62%. The current CWS drawdown is -5.82%.

Rank	SBIO	CWS
#1	-63.06% Feb 8, 2021 - Oct 27, 2023	-33.82% Feb 19, 2020 - Aug 12, 2020
#2	-49.69% Jul 17, 2015 - Jun 6, 2018	-24.87% Dec 31, 2021 - Jun 15, 2023
#3	-39.30% Dec 24, 2019 - Jun 23, 2020	-18.40% Sep 13, 2018 - Jun 5, 2019
#4	-32.42% Sep 28, 2018 - Nov 25, 2019	-16.56% Nov 29, 2024 - Jan 12, 2026
#5	-13.78% Apr 23, 2015 - May 20, 2015	-13.07% Aug 1, 2023 - Dec 1, 2023
#6	-13.03% Jun 23, 2020 - Oct 7, 2020	-11.92% Jan 16, 2026 - Mar 30, 2026
#7	-11.31% Mar 19, 2015 - Apr 13, 2015	-9.59% Jan 29, 2018 - Jul 26, 2018
#8	-6.72% Jun 6, 2018 - Sep 28, 2018	-6.59% Sep 2, 2020 - Oct 9, 2020
#9	-6.30% Jan 27, 2015 - Feb 17, 2015	-6.48% Oct 14, 2020 - Nov 6, 2020
#10	-6.29% Jun 22, 2015 - Jul 13, 2015	-6.20% Mar 28, 2024 - May 15, 2024
#11	-6.19% Dec 22, 2020 - Jan 7, 2021	-6.11% Sep 2, 2021 - Oct 29, 2021
#12	-4.88% Oct 13, 2020 - Oct 27, 2020	-5.77% Jan 8, 2021 - Mar 15, 2021
#13	-3.81% Jan 14, 2015 - Jan 20, 2015	-4.79% Apr 23, 2021 - Jul 29, 2021
#14	-3.39% Oct 27, 2020 - Nov 4, 2020	-4.51% Sep 22, 2016 - Nov 10, 2016
#15	-3.31% Jan 26, 2021 - Feb 1, 2021	-4.34% Jul 26, 2019 - Sep 6, 2019