RNTX vs ANVS

Comparison between Rein Therapeutics Inc (RNTX, Company) and Annovis Bio Inc (ANVS, Company).

Both RNTX and ANVS are from the Healthcare sector.

5-Year PerformanceRNTX has outperformed ANVS, delivering a return of -47.5% compared to -56.5%

RNTX vs ANVS - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	RNTX(COMPANY)	ANVS(COMPANY)
Market Cap	$52M	$52M
Max Drawdown	99.72%	98.99%
Sharpe Ratio	-0.08	-0.05
5Y Beta	0.88	1.59
Industry	Biotechnology	Biotechnology
P/E Ratio	-0.97	-1.09
5Y EPS CAGR	-37.84%	6.84%
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-37.38%	-51.37%
P/B Ratio	28.17	23.95

Market Cap

Winner

RNTX

$52M

ANVS

$52M

Max Drawdown

RNTX

99.72%

Winner

ANVS

98.99%

Sharpe Ratio

RNTX

-0.08

Winner

ANVS

-0.05

5Y Beta

Winner

RNTX

0.88

ANVS

1.59

Industry

RNTX

Biotechnology

ANVS

Biotechnology

P/E Ratio

RNTX

-0.97

Winner

ANVS

-1.09

5Y EPS CAGR

RNTX

-37.84%

Winner

ANVS

6.84%

Debt to Equity

RNTX

0.00%

ANVS

0.00%

Free Cash Flow Yield

Winner

RNTX

-37.38%

ANVS

-51.37%

P/B Ratio

RNTX

28.17

Winner

ANVS

23.95

RNTX vs ANVS - Historical Returns

Returns include dividend reinvestment.

Period	RNTX	ANVS
1 month	-1.01%	-1.98%
3 months	-52.15%	-6.72%
6 months	-26.05%	-39.76%
1 year	-37.86%	-31.42%
5 years(CAGR)	-47.49%	-56.47%
10 years(CAGR)	-8.78%	N/A
Max(CAGR)	-12.94%	-23.21%

Winner

RNTX

-1.01%

ANVS

-1.98%

RNTX

-52.15%

Winner

ANVS

-6.72%

Winner

RNTX

-26.05%

ANVS

-39.76%

RNTX

-37.86%

Winner

ANVS

-31.42%

5Y(CAGR)

Winner

RNTX

-47.49%

ANVS

-56.47%

10Y(CAGR)

RNTX

-8.78%

ANVS

N/A

Max(CAGR)

Winner

RNTX

-12.94%

ANVS

-23.21%

RNTX vs ANVS - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	RNTX	ANVS
2026	-28.42%	-52.47%
2025	-48.44%	-32.29%
2024	-26.28%	-73.43%
2023	-4.73%	+43.96%
2022	-80.11%	-32.10%
2021	-46.39%	+115.71%
2020	+74.79%	-21.38%
2019	-43.82%	N/A
2018	-92.02%	N/A
2017	+9302.32%	N/A
2016	+0.00%	N/A
2015	+0.00%	N/A
2014	+0.00%	N/A
2013	-77.52%	N/A
2012	-71.66%	N/A
2011	-22.46%	N/A
2010	+215.48%	N/A
2009	+21.67%	N/A
2008	-31.03%	N/A
2007	-56.50%	N/A
2006	+12.00%	N/A
2005	-14.85%	N/A
2004	-11.90%	N/A
2003	+70.25%	N/A
2002	+1.94%	N/A
2001	-31.11%	N/A
2000	+12.12%	N/A
1999	+13.79%	N/A

RNTX vs ANVS Drawdown Comparison

The maximum drawdown for RNTX was -99.72%, occurring on Jul 20, 2026. This drawdown has not yet recovered.

The maximum drawdown for ANVS was -98.99%, occurring on Apr 8, 2025. This drawdown has not yet recovered.

The current RNTX drawdown is -99.70%. The current ANVS drawdown is -98.57%.

Rank	RNTX	ANVS
#1	-99.72% Oct 4, 2017 - Jul 20, 2026	-98.99% Jul 13, 2021 - Apr 8, 2025
#2	-97.95% Feb 17, 2004 - Jun 29, 2017	-73.93% Jan 29, 2020 - Jan 13, 2021
#3	-64.00% Mar 20, 2000 - Feb 9, 2004	-43.94% Mar 17, 2021 - May 21, 2021
#4	-26.17% Jan 4, 2000 - Mar 14, 2000	-25.67% May 21, 2021 - Jun 3, 2021
#5	-18.78% Sep 7, 2017 - Oct 2, 2017	-25.05% Feb 22, 2021 - Mar 15, 2021
#6	-17.25% Jul 7, 2017 - Sep 7, 2017	-17.86% Jun 21, 2021 - Jul 2, 2021
#7	-16.15% Nov 2, 1999 - Nov 12, 1999	-13.29% Feb 4, 2021 - Feb 9, 2021
#8	-13.14% Dec 21, 1999 - Jan 4, 2000	-6.06% Jun 8, 2021 - Jun 10, 2021
#9	-11.43% Nov 22, 1999 - Dec 3, 1999	-5.95% Jan 26, 2021 - Feb 2, 2021
#10	-10.81% Dec 9, 1999 - Dec 21, 1999	-5.61% Jun 16, 2021 - Jun 21, 2021
#11	-3.85% Mar 14, 2000 - Mar 17, 2000	-5.47% Jul 8, 2021 - Jul 12, 2021
#12	-3.05% Nov 15, 1999 - Nov 22, 1999	-5.16% Jun 11, 2021 - Jun 16, 2021
#13	-2.53% Feb 10, 2004 - Feb 17, 2004	-2.06% Mar 15, 2021 - Mar 17, 2021
#14	-2.30% Jul 3, 2017 - Jul 6, 2017	-1.24% Jan 14, 2021 - Jan 21, 2021
#15	-0.07% Oct 2, 2017 - Oct 4, 2017	-0.43% Jan 22, 2021 - Jan 26, 2021