RGLS vs GUG

Comparison between Regulus Therapeutics Inc (RGLS, Company) and Guggenheim Active Allocation Fund (GUG, Company).

5-Year PerformanceGUG has outperformed RGLS, delivering a return of +4.5% compared to +0.4%

RGLS vs GUG - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	RGLS(COMPANY)	GUG(COMPANY)
Market Cap	$540M	$536M
Max Drawdown	99.97%	37.03%
Sharpe Ratio	1.24	0.94
5Y Beta	N/A	0.35
Industry	N/A	Asset Management
P/E Ratio	-10.76	11.61
Debt to Equity	0.00%	31.43%
Free Cash Flow Yield	-8.08%	5.85%
P/S Ratio	0.57	12.52
P/B Ratio	7.82	0.96

Market Cap

Winner

RGLS

$540M

GUG

$536M

Max Drawdown

RGLS

99.97%

Winner

GUG

37.03%

Sharpe Ratio

Winner

RGLS

1.24

GUG

0.94

5Y Beta

RGLS

N/A

GUG

0.35

Industry

RGLS

N/A

GUG

Asset Management

P/E Ratio

Winner

RGLS

-10.76

GUG

11.61

Debt to Equity

Winner

RGLS

0.00%

GUG

31.43%

Free Cash Flow Yield

RGLS

-8.08%

Winner

GUG

5.85%

P/S Ratio

Winner

RGLS

0.57

GUG

12.52

P/B Ratio

RGLS

7.82

Winner

GUG

0.96

RGLS vs GUG - Historical Returns

Returns include dividend reinvestment.

Period	RGLS	GUG
1 month	+3.42%	+2.98%
3 months	+527.69%	+5.27%
6 months	+429.87%	+7.39%
1 year	+281.31%	+14.95%
5 years(CAGR)	+0.40%	+4.53%
10 years(CAGR)	-39.42%	N/A
Max(CAGR)	-27.95%	+4.53%

Winner

RGLS

+3.42%

GUG

+2.98%

Winner

RGLS

+527.69%

GUG

+5.27%

Winner

RGLS

+429.87%

GUG

+7.39%

Winner

RGLS

+281.31%

GUG

+14.95%

5Y(CAGR)

RGLS

+0.40%

Winner

GUG

+4.53%

10Y(CAGR)

RGLS

-39.42%

GUG

N/A

Max(CAGR)

RGLS

-27.95%

Winner

GUG

+4.53%

RGLS vs GUG - Annual Returns (2012 - 2026)

Returns include dividend reinvestment.

Year	RGLS	GUG
2026	N/A	+10.25%
2025	+423.08%	+12.35%
2024	+20.61%	+11.59%
2023	-5.88%	+19.29%
2022	-58.23%	-26.97%
2021	-75.77%	-0.20%
2020	+33.66%	N/A
2019	-19.82%	N/A
2018	-93.14%	N/A
2017	-54.78%	N/A
2016	-73.75%	N/A
2015	-49.27%	N/A
2014	+117.93%	N/A
2013	+15.65%	N/A
2012	+43.84%	N/A

RGLS vs GUG Drawdown Comparison

The maximum drawdown for RGLS was -99.97%, occurring on Mar 27, 2023. This drawdown has not yet recovered.

The maximum drawdown for GUG was -32.74%, occurring on Sep 29, 2022. Recovery took 675 trading sessions.

The current RGLS drawdown is -99.69%. The current GUG drawdown is -2.02%.

Rank	RGLS	GUG
#1	-99.97% Nov 7, 2014 - Mar 27, 2023	-32.74% Dec 21, 2021 - Aug 29, 2024
#2	-53.26% Jul 11, 2013 - Oct 22, 2014	-12.09% Sep 16, 2024 - Jun 24, 2025
#3	-25.98% Jan 2, 2013 - Mar 13, 2013	-7.80% Feb 13, 2026 - May 21, 2026
#4	-16.39% Mar 28, 2013 - May 29, 2013	-6.10% Oct 7, 2025 - Jan 13, 2026
#5	-15.76% Oct 25, 2012 - Dec 19, 2012	-4.08% May 28, 2026 - Jul 14, 2026
#6	-10.59% Jun 21, 2013 - Jul 2, 2013	-3.53% Sep 11, 2025 - Oct 7, 2025
#7	-6.27% Nov 4, 2014 - Nov 7, 2014	-2.62% Jun 25, 2025 - Aug 12, 2025
#8	-5.25% Oct 9, 2012 - Oct 18, 2012	-2.02% Jul 17, 2026 - Jul 21, 2026
#9	-4.66% Oct 27, 2014 - Oct 31, 2014	-1.71% Jan 14, 2026 - Feb 5, 2026
#10	-4.43% Mar 20, 2013 - Mar 22, 2013	-1.05% Sep 4, 2025 - Sep 9, 2025
#11	-1.99% Jun 13, 2013 - Jun 20, 2013	-0.90% Aug 14, 2025 - Aug 22, 2025
#12	-1.62% Jun 3, 2013 - Jun 10, 2013	-0.90% Aug 30, 2024 - Sep 5, 2024
#13	-0.96% Dec 20, 2012 - Dec 27, 2012	-0.86% Feb 9, 2026 - Feb 13, 2026
#14	-0.74% Mar 15, 2013 - Mar 20, 2013	-0.74% Sep 9, 2025 - Sep 11, 2025
#15	-0.31% Mar 13, 2013 - Mar 15, 2013	-0.64% Aug 25, 2025 - Aug 28, 2025