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RGLS vs SPY

Comparison between Regulus Therapeutics Inc (RGLS, Company) and SPDR S&P 500 ETF Trust (SPY, ETF).

5-Year PerformanceSPY has outperformed RGLS, delivering a return of +13.3% compared to +0.4%

RGLS vs SPY - Performance Comparison

Key Characteristics

Financial metrics and valuation ratios

Market Cap / Net Assets
RGLS
$540M
Winner
SPY
$735B
Expense Ratio
RGLS
N/A
SPY
0.09%
Max Drawdown
RGLS
99.97%
Winner
SPY
56.47%
Sharpe Ratio
RGLS
1.24
Winner
SPY
1.62
5Y Beta
RGLS
N/A
SPY
1.00
P/E Ratio
Winner
RGLS
-10.76
SPY
28.99
Forward P/E
RGLS
N/A
SPY
22.37
5Y Dividends CAGR
RGLS
N/A
SPY
5.43%
5Y EPS CAGR
RGLS
N/A
SPY
26.05%
Debt to Equity
Winner
RGLS
0.00%
SPY
32.40%
Free Cash Flow Yield
RGLS
-8.08%
SPY
N/A
P/S Ratio
Winner
RGLS
0.57
SPY
3.74
P/B Ratio
RGLS
7.82
Winner
SPY
5.61

RGLS vs SPY - Historical Returns

Returns include dividend reinvestment.

1M
Winner
RGLS
+3.42%
SPY
+1.90%
3M
Winner
RGLS
+527.69%
SPY
+8.55%
6M
Winner
RGLS
+429.87%
SPY
+8.18%
1Y
Winner
RGLS
+281.31%
SPY
+25.79%
5Y(CAGR)
RGLS
+0.40%
Winner
SPY
+13.32%
10Y(CAGR)
RGLS
-39.42%
Winner
SPY
+15.19%
Max(CAGR)
RGLS
-27.95%
Winner
SPY
+8.47%

RGLS vs SPY - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

YearRGLSSPY
2026N/A+8.26%
2025+423.08%+18.00%
2024+20.61%+25.59%
2023-5.88%+26.72%
2022-58.23%-18.64%
2021-75.77%+30.52%
2020+33.66%+17.28%
2019-19.82%+31.09%
2018-93.14%-5.24%
2017-54.78%+20.78%
2016-73.75%+13.59%
2015-49.27%+1.31%
2014+117.93%+14.56%
2013+15.65%+29.00%
2012+43.84%+14.17%
2011N/A+0.85%
2010N/A+13.14%
2009N/A+22.67%
2008N/A-36.25%
2007N/A+5.32%
2006N/A+13.85%
2005N/A+5.32%
2004N/A+10.75%
2003N/A+24.18%
2002N/A-22.42%
2001N/A-10.13%
2000N/A-8.84%
1999N/A+8.61%

RGLS vs SPY Drawdown Comparison

The maximum drawdown for RGLS was -99.97%, occurring on Mar 27, 2023. This drawdown has not yet recovered.

The maximum drawdown for SPY was -55.20%, occurring on Mar 9, 2009. Recovery took 1224 trading sessions.

The current RGLS drawdown is -99.69%. The current SPY drawdown is -2.90%.

RankRGLSSPY
#1-99.97%
Nov 7, 2014 - Mar 27, 2023
-55.20%
Oct 9, 2007 - Aug 16, 2012
#2-53.26%
Jul 11, 2013 - Oct 22, 2014
-47.50%
Mar 24, 2000 - Oct 26, 2006
#3-25.98%
Jan 2, 2013 - Mar 13, 2013
-33.70%
Feb 19, 2020 - Aug 10, 2020
#4-16.39%
Mar 28, 2013 - May 29, 2013
-24.50%
Jan 3, 2022 - Dec 13, 2023
#5-15.76%
Oct 25, 2012 - Dec 19, 2012
-19.34%
Sep 20, 2018 - Apr 12, 2019
#6-10.59%
Jun 21, 2013 - Jul 2, 2013
-18.76%
Feb 19, 2025 - Jun 26, 2025
#7-6.27%
Nov 4, 2014 - Nov 7, 2014
-13.02%
Jul 20, 2015 - Apr 18, 2016
#8-5.25%
Oct 9, 2012 - Oct 18, 2012
-10.10%
Jan 26, 2018 - Aug 6, 2018
#9-4.66%
Oct 27, 2014 - Oct 31, 2014
-9.44%
Sep 2, 2020 - Nov 11, 2020
#10-4.43%
Mar 20, 2013 - Mar 22, 2013
-9.30%
Jan 19, 2000 - Mar 17, 2000
#11-1.99%
Jun 13, 2013 - Jun 20, 2013
-9.05%
Jul 19, 2007 - Oct 5, 2007
#12-1.62%
Jun 3, 2013 - Jun 10, 2013
-8.88%
Jan 27, 2026 - Apr 14, 2026
#13-0.96%
Dec 20, 2012 - Dec 27, 2012
-8.41%
Jul 16, 2024 - Sep 19, 2024
#14-0.74%
Mar 15, 2013 - Mar 20, 2013
-7.35%
Sep 14, 2012 - Jan 2, 2013
#15-0.31%
Mar 13, 2013 - Mar 15, 2013
-7.27%
Sep 18, 2014 - Oct 31, 2014

Correlation

Correlation between RGLS and SPY is -0.62 which considered as a moderate negative correlation - the stocks show some tendency to move in opposite directions.

-0.62
-101

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