RGEN vs SYRE

Comparison between Repligen Corp (RGEN, Company) and Spyre Therapeutics Inc (SYRE, Company).

Both RGEN and SYRE are from the Healthcare sector.

5-Year PerformanceRGEN has outperformed SYRE, delivering a return of -9.5% compared to -17.6%

RGEN vs SYRE - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	RGEN(COMPANY)	SYRE(COMPANY)
Market Cap	$6.04B	$6.02B
Max Drawdown	92.06%	99.11%
Sharpe Ratio	-0.24	2.61
5Y Beta	1.39	1.73
Industry	Medical Instruments & Supplies	Biotechnology
P/E Ratio	117.25	-30.92
Forward P/E	62.50	N/A
PEG Ratio	0.45	N/A
5Y EPS CAGR	9.09%	-2.15%
Debt to Equity	25.96%	0.00%
Free Cash Flow Yield	1.76%	-3.09%
P/S Ratio	7.91	650.22
P/B Ratio	3.31	12.65

Market Cap

Winner

RGEN

$6.04B

SYRE

$6.02B

Max Drawdown

Winner

RGEN

92.06%

SYRE

99.11%

Sharpe Ratio

RGEN

-0.24

Winner

SYRE

2.61

5Y Beta

Winner

RGEN

1.39

SYRE

1.73

Industry

RGEN

Medical Instruments & Supplies

SYRE

Biotechnology

P/E Ratio

RGEN

117.25

Winner

SYRE

-30.92

Forward P/E

RGEN

62.50

SYRE

N/A

PEG Ratio

RGEN

0.45

SYRE

N/A

5Y EPS CAGR

Winner

RGEN

9.09%

SYRE

-2.15%

Debt to Equity

RGEN

25.96%

Winner

SYRE

0.00%

Free Cash Flow Yield

Winner

RGEN

1.76%

SYRE

-3.09%

P/S Ratio

Winner

RGEN

7.91

SYRE

650.22

P/B Ratio

Winner

RGEN

3.31

SYRE

12.65

RGEN vs SYRE - Historical Returns

Returns include dividend reinvestment.

Period	RGEN	SYRE
1 month	-20.59%	-4.01%
3 months	-24.55%	+91.48%
6 months	-31.92%	+190.79%
1 year	-17.43%	+370.97%
5 years(CAGR)	-9.54%	-17.65%
10 years(CAGR)	+14.81%	-9.26%
Max(CAGR)	+14.04%	-11.62%

RGEN

-20.59%

Winner

SYRE

-4.01%

RGEN

-24.55%

Winner

SYRE

+91.48%

RGEN

-31.92%

Winner

SYRE

+190.79%

RGEN

-17.43%

Winner

SYRE

+370.97%

5Y(CAGR)

Winner

RGEN

-9.54%

SYRE

-17.65%

10Y(CAGR)

Winner

RGEN

+14.81%

SYRE

-9.26%

Max(CAGR)

Winner

RGEN

+14.04%

SYRE

-11.62%

RGEN vs SYRE - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	RGEN	SYRE
2026	-36.60%	+129.17%
2025	+14.55%	+37.36%
2024	-19.72%	+8.79%
2023	+10.99%	+104.27%
2022	-34.37%	-90.57%
2021	+38.91%	-44.51%
2020	+104.34%	+1.55%
2019	+78.95%	-4.98%
2018	+42.31%	+39.22%
2017	+16.47%	+18.38%
2016	+9.68%	-55.48%
2015	+40.75%	N/A
2014	+56.77%	N/A
2013	+105.73%	N/A
2012	+79.43%	N/A
2011	-23.23%	N/A
2010	+16.09%	N/A
2009	+4.85%	N/A
2008	-43.16%	N/A
2007	+133.93%	N/A
2006	-27.95%	N/A
2005	+37.93%	N/A
2004	-30.77%	N/A
2003	+47.14%	N/A
2002	+13.01%	N/A
2001	-31.63%	N/A
2000	+10.19%	N/A
1999	-1.98%	N/A

RGEN vs SYRE Drawdown Comparison

The maximum drawdown for RGEN was -92.06%, occurring on Jul 23, 2004. Recovery took 3565 trading sessions.

The maximum drawdown for SYRE was -99.11%, occurring on Jun 21, 2023. This drawdown has not yet recovered.

The current RGEN drawdown is -67.86%. The current SYRE drawdown is -76.62%.

Rank	RGEN	SYRE
#1	-92.06% Mar 3, 2000 - May 7, 2014	-99.11% Apr 8, 2016 - Jun 21, 2023
#2	-68.27% Sep 23, 2021 - May 15, 2026	N/A
#3	-50.33% Jul 7, 2015 - Jun 23, 2017	N/A
#4	-39.47% Nov 18, 1999 - Jan 24, 2000	N/A
#5	-32.87% Sep 18, 2017 - Jun 22, 2018	N/A
#6	-29.94% Nov 8, 2018 - Apr 26, 2019	N/A
#7	-26.69% Feb 12, 2021 - Jul 27, 2021	N/A
#8	-26.06% Feb 18, 2000 - Mar 1, 2000	N/A
#9	-24.16% Jul 14, 2014 - Oct 28, 2014	N/A
#10	-23.73% Oct 30, 2014 - Jan 16, 2015	N/A
#11	-22.69% Aug 1, 2019 - Jan 9, 2020	N/A
#12	-22.16% Feb 19, 2020 - Apr 22, 2020	N/A
#13	-19.46% May 15, 2020 - Jul 30, 2020	N/A
#14	-17.65% Feb 10, 2000 - Feb 15, 2000	N/A
#15	-15.69% Jan 19, 2021 - Feb 11, 2021	N/A

Correlation

Correlation between RGEN and SYRE is -0.36 which considered as a weak negative correlation - the stocks show a slight tendency to move in opposite directions.

-0.36

-101