SYRE vs CELC

Comparison between Spyre Therapeutics Inc (SYRE, Company) and Celcuity Inc (CELC, Company).

Both SYRE and CELC are from the Healthcare sector.

5-Year PerformanceCELC has outperformed SYRE, delivering a return of +37.1% compared to -17.6%

SYRE vs CELC - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SYRE(COMPANY)	CELC(COMPANY)
Market Cap	$6.02B	$6.01B
Max Drawdown	99.11%	85.64%
Sharpe Ratio	2.61	1.90
5Y Beta	1.73	1.07
Industry	Biotechnology	Biotechnology
P/E Ratio	-30.92	-29.57
PEG Ratio	N/A	-0.86
5Y EPS CAGR	-2.15%	37.13%
Debt to Equity	0.00%	136.79%
Free Cash Flow Yield	-3.09%	-2.56%
P/S Ratio	650.22	N/A
P/B Ratio	12.65	63.02

Market Cap

Winner

SYRE

$6.02B

CELC

$6.01B

Max Drawdown

SYRE

99.11%

Winner

CELC

85.64%

Sharpe Ratio

Winner

SYRE

2.61

CELC

1.90

5Y Beta

SYRE

1.73

Winner

CELC

1.07

Industry

SYRE

Biotechnology

CELC

Biotechnology

P/E Ratio

Winner

SYRE

-30.92

CELC

-29.57

PEG Ratio

SYRE

N/A

CELC

-0.86

5Y EPS CAGR

SYRE

-2.15%

Winner

CELC

37.13%

Debt to Equity

Winner

SYRE

0.00%

CELC

136.79%

Free Cash Flow Yield

SYRE

-3.09%

Winner

CELC

-2.56%

P/S Ratio

SYRE

650.22

CELC

N/A

P/B Ratio

Winner

SYRE

12.65

CELC

63.02

SYRE vs CELC - Historical Returns

Returns include dividend reinvestment.

Period	SYRE	CELC
1 month	-4.01%	+7.94%
3 months	+91.48%	+25.04%
6 months	+190.79%	+44.30%
1 year	+370.97%	+1136.48%
5 years(CAGR)	-17.65%	+37.14%
10 years(CAGR)	-9.26%	+29.30%
Max(CAGR)	-11.62%	+29.30%

SYRE

-4.01%

Winner

CELC

+7.94%

Winner

SYRE

+91.48%

CELC

+25.04%

Winner

SYRE

+190.79%

CELC

+44.30%

SYRE

+370.97%

Winner

CELC

+1136.48%

5Y(CAGR)

SYRE

-17.65%

Winner

CELC

+37.14%

10Y(CAGR)

SYRE

-9.26%

Winner

CELC

+29.30%

Max(CAGR)

SYRE

-11.62%

Winner

CELC

+29.30%

SYRE vs CELC - Annual Returns (2016 - 2026)

Returns include dividend reinvestment.

Year	SYRE	CELC
2026	+129.17%	+31.46%
2025	+37.36%	+659.63%
2024	+8.79%	-11.43%
2023	+104.27%	+13.65%
2022	-90.57%	+5.10%
2021	-44.51%	+26.46%
2020	+1.55%	-21.58%
2019	-4.98%	-53.46%
2018	+39.22%	+16.91%
2017	+18.38%	+32.61%
2016	-55.48%	N/A

SYRE vs CELC Drawdown Comparison

The maximum drawdown for SYRE was -99.11%, occurring on Jun 21, 2023. This drawdown has not yet recovered.

The maximum drawdown for CELC was -85.64%, occurring on Apr 16, 2020. Recovery took 696 trading sessions.

The current SYRE drawdown is -76.62%. The current CELC drawdown is -8.83%.

Rank	SYRE	CELC
#1	-99.11% Apr 8, 2016 - Jun 21, 2023	-85.64% Sep 20, 2018 - Jun 28, 2021
#2	N/A	-82.70% Jun 28, 2021 - Jul 28, 2025
#3	N/A	-37.41% Nov 10, 2017 - Jun 22, 2018
#4	N/A	-27.68% Sep 8, 2025 - Oct 20, 2025
#5	N/A	-22.34% Jun 27, 2018 - Sep 14, 2018
#6	N/A	-16.45% Sep 20, 2017 - Oct 13, 2017
#7	N/A	-14.15% May 4, 2026 - May 13, 2026
#8	N/A	-13.00% Jan 27, 2026 - Apr 9, 2026
#9	N/A	-9.92% Apr 21, 2026 - May 4, 2026
#10	N/A	-8.04% Jan 14, 2026 - Jan 27, 2026
#11	N/A	-7.56% Oct 30, 2025 - Nov 11, 2025
#12	N/A	-7.20% Oct 20, 2025 - Oct 24, 2025
#13	N/A	-6.87% Aug 13, 2025 - Aug 22, 2025
#14	N/A	-6.44% Dec 4, 2025 - Jan 7, 2026
#15	N/A	-6.17% Aug 28, 2025 - Sep 5, 2025