QCRH vs SEPN

Comparison between QCR Holding Inc (QCRH, Company) and Septerna Inc (SEPN, Company).

QCRH is from the Financial Services sector, while SEPN is from the Healthcare sector.

QCRH vs SEPN - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	QCRH(COMPANY)	SEPN(COMPANY)
Market Cap	$1.74B	$1.74B
Max Drawdown	68.99%	81.47%
Sharpe Ratio	1.55	2.10
5Y Beta	0.77	1.27
Industry	Banks - Regional	Biotechnology
P/E Ratio	13.08	-48.08
Forward P/E	12.20	107.53
PEG Ratio	0.64	N/A
Dividend Yield	0.12%	N/A
5Y Dividends CAGR	4.84%	N/A
5Y EPS CAGR	13.59%	N/A
Debt to Equity	0.17%	0.00%
Free Cash Flow Yield	20.65%	6.14%
P/S Ratio	4.55	24.18
P/B Ratio	1.50	4.11

Market Cap

QCRH

$1.74B

Winner

SEPN

$1.74B

Max Drawdown

Winner

QCRH

68.99%

SEPN

81.47%

Sharpe Ratio

QCRH

1.55

Winner

SEPN

2.10

5Y Beta

Winner

QCRH

0.77

SEPN

1.27

Industry

QCRH

Banks - Regional

SEPN

Biotechnology

P/E Ratio

QCRH

13.08

Winner

SEPN

-48.08

Forward P/E

Winner

QCRH

12.20

SEPN

107.53

PEG Ratio

QCRH

0.64

SEPN

N/A

Dividend Yield

QCRH

0.12%

SEPN

N/A

5Y Dividends CAGR

QCRH

4.84%

SEPN

N/A

5Y EPS CAGR

QCRH

13.59%

SEPN

N/A

Debt to Equity

QCRH

0.17%

Winner

SEPN

0.00%

Free Cash Flow Yield

Winner

QCRH

20.65%

SEPN

6.14%

P/S Ratio

Winner

QCRH

4.55

SEPN

24.18

P/B Ratio

Winner

QCRH

1.50

SEPN

4.11

QCRH vs SEPN - Historical Returns

Returns include dividend reinvestment.

Period	QCRH	SEPN
1 month	+8.31%	+8.37%
3 months	+13.69%	+61.93%
6 months	+9.13%	+52.81%
1 year	+49.13%	+231.88%
5 years(CAGR)	+16.08%	N/A
10 years(CAGR)	+14.06%	N/A
Max(CAGR)	+9.23%	+39.69%

QCRH

+8.31%

Winner

SEPN

+8.37%

QCRH

+13.69%

Winner

SEPN

+61.93%

QCRH

+9.13%

Winner

SEPN

+52.81%

QCRH

+49.13%

Winner

SEPN

+231.88%

5Y(CAGR)

QCRH

+16.08%

SEPN

N/A

10Y(CAGR)

QCRH

+14.06%

SEPN

N/A

Max(CAGR)

QCRH

+9.23%

Winner

SEPN

+39.69%

QCRH vs SEPN - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	QCRH	SEPN
2026	+26.74%	+38.78%
2025	+5.42%	+30.59%
2024	+38.47%	+7.01%
2023	+18.70%	N/A
2022	-11.31%	N/A
2021	+44.02%	N/A
2020	-7.65%	N/A
2019	+35.16%	N/A
2018	-23.06%	N/A
2017	+1.04%	N/A
2016	+87.73%	N/A
2015	+36.17%	N/A
2014	+5.41%	N/A
2013	+28.69%	N/A
2012	+45.74%	N/A
2011	+26.63%	N/A
2010	-12.70%	N/A
2009	-20.54%	N/A
2008	-29.85%	N/A
2007	-17.92%	N/A
2006	-6.63%	N/A
2005	-8.01%	N/A
2004	+12.96%	N/A
2003	+65.20%	N/A
2002	+47.02%	N/A
2001	+8.00%	N/A
2000	-27.02%	N/A
1999	-19.40%	N/A

QCRH vs SEPN Drawdown Comparison

The maximum drawdown for QCRH was -67.85%, occurring on Dec 30, 2010. Recovery took 2471 trading sessions.

The maximum drawdown for SEPN was -81.47%, occurring on Apr 1, 2025. Recovery took 230 trading sessions.

The current QCRH drawdown is -1.40%. The current SEPN drawdown is -1.77%.

Rank	QCRH	SEPN
#1	-67.85% Jul 26, 2005 - May 20, 2015	-81.47% Dec 23, 2024 - Nov 24, 2025
#2	-52.99% Jul 9, 2018 - Apr 5, 2021	-25.18% Feb 24, 2026 - May 28, 2026
#3	-46.97% Nov 4, 1999 - Jan 16, 2003	-21.10% Dec 19, 2025 - Feb 17, 2026
#4	-41.58% Aug 18, 2022 - Jan 29, 2024	-16.77% Dec 4, 2024 - Dec 23, 2024
#5	-32.12% Nov 26, 2024 - Feb 5, 2026	-16.60% Jul 9, 2026 - Aug 4, 2026
#6	-17.82% Jan 18, 2022 - Aug 16, 2022	-16.19% Nov 7, 2024 - Dec 4, 2024
#7	-17.50% Jan 30, 2004 - Dec 16, 2004	-13.97% Nov 26, 2025 - Dec 19, 2025
#8	-15.39% Jun 13, 2017 - Oct 20, 2017	-10.63% Feb 17, 2026 - Feb 24, 2026
#9	-15.32% Dec 29, 2015 - Apr 19, 2016	-10.36% Jun 26, 2026 - Jul 9, 2026
#10	-15.26% Feb 6, 2026 - Jun 10, 2026	-6.45% Oct 25, 2024 - Oct 31, 2024
#11	-14.88% Oct 20, 2017 - Jun 6, 2018	-5.55% Jun 23, 2026 - Jun 26, 2026
#12	-12.23% Jan 29, 2024 - Jul 11, 2024	-4.76% Oct 31, 2024 - Nov 4, 2024
#13	-11.35% Jul 31, 2003 - Oct 24, 2003	-3.65% Jun 18, 2026 - Jun 23, 2026
#14	-10.72% Nov 5, 2021 - Jan 10, 2022	-3.57% May 28, 2026 - Jun 4, 2026
#15	-10.60% Jul 17, 2015 - Oct 21, 2015	-3.45% Nov 4, 2024 - Nov 6, 2024