PTGX vs GKOS

Comparison between Protagonist Therapeutics Inc (PTGX, Company) and Glaukos Corporation (GKOS, Company).

Both PTGX and GKOS are from the Healthcare sector.

5-Year PerformancePTGX has outperformed GKOS, delivering a return of +23.2% compared to +12.5%

PTGX vs GKOS - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	PTGX(COMPANY)	GKOS(COMPANY)
Market Cap	$8.04B	$8.03B
Max Drawdown	85.79%	69.57%
Sharpe Ratio	1.77	0.73
5Y Beta	0.24	1.30
Industry	Biotechnology	Medical Devices
P/E Ratio	-68.02	-41.82
Forward P/E	25.97	2000.00
PEG Ratio	N/A	-0.87
5Y EPS CAGR	1.43%	12.32%
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-1.47%	-0.23%

Market Cap

Winner

PTGX

$8.04B

GKOS

$8.03B

Max Drawdown

PTGX

85.79%

Winner

GKOS

69.57%

Sharpe Ratio

Winner

PTGX

1.77

GKOS

0.73

5Y Beta

Winner

PTGX

0.24

GKOS

1.30

Industry

PTGX

Biotechnology

GKOS

Medical Devices

P/E Ratio

Winner

PTGX

-68.02

GKOS

-41.82

Forward P/E

Winner

PTGX

25.97

GKOS

2000.00

PEG Ratio

PTGX

N/A

GKOS

-0.87

5Y EPS CAGR

PTGX

1.43%

Winner

GKOS

12.32%

Debt to Equity

PTGX

0.00%

GKOS

0.00%

Free Cash Flow Yield

PTGX

-1.47%

Winner

GKOS

-0.23%

PTGX vs GKOS - Historical Returns

Returns include dividend reinvestment.

Period	PTGX	GKOS
1 month	+41.18%	+33.97%
3 months	+26.83%	+31.60%
6 months	+50.97%	+34.04%
1 year	+159.66%	+43.21%
5 years(CAGR)	+23.21%	+12.48%
10 years(CAGR)	+27.73%	+17.61%
Max(CAGR)	+27.73%	+15.20%

Winner

PTGX

+41.18%

GKOS

+33.97%

PTGX

+26.83%

Winner

GKOS

+31.60%

Winner

PTGX

+50.97%

GKOS

+34.04%

Winner

PTGX

+159.66%

GKOS

+43.21%

5Y(CAGR)

Winner

PTGX

+23.21%

GKOS

+12.48%

10Y(CAGR)

Winner

PTGX

+27.73%

GKOS

+17.61%

Max(CAGR)

Winner

PTGX

+27.73%

GKOS

+15.20%

PTGX vs GKOS - Annual Returns (2015 - 2026)

Returns include dividend reinvestment.

Year	PTGX	GKOS
2026	+50.97%	+34.04%
2025	+124.06%	-24.57%
2024	+64.82%	+94.53%
2023	+112.71%	+81.15%
2022	-69.11%	-7.89%
2021	+74.49%	-36.90%
2020	+190.91%	+38.27%
2019	+2.32%	+1.34%
2018	-68.18%	+107.42%
2017	-1.79%	-23.93%
2016	+87.95%	+43.82%
2015	N/A	-20.92%

PTGX vs GKOS Drawdown Comparison

The maximum drawdown for PTGX was -85.79%, occurring on Jun 13, 2022. Recovery took 882 trading sessions.

The maximum drawdown for GKOS was -69.57%, occurring on Mar 20, 2020. Recovery took 366 trading sessions.

The current GKOS drawdown is -7.95%.

Rank	PTGX	GKOS
#1	-85.79% Sep 1, 2021 - Mar 10, 2025	-69.57% Aug 1, 2019 - Jan 13, 2021
#2	-82.13% Dec 5, 2016 - Feb 16, 2021	-64.32% Apr 28, 2021 - Apr 8, 2024
#3	-31.58% Mar 11, 2025 - Aug 27, 2025	-55.00% Aug 18, 2015 - Jul 21, 2016
#4	-20.33% Oct 17, 2016 - Nov 10, 2016	-53.68% Jan 23, 2025 - Oct 24, 2025
#5	-19.04% Mar 19, 2021 - May 18, 2021	-53.09% Apr 3, 2017 - Aug 29, 2018
#6	-16.38% Dec 12, 2025 - Mar 9, 2026	-25.77% Aug 31, 2018 - Feb 12, 2019
#7	-15.52% Oct 10, 2025 - Nov 24, 2025	-22.03% Sep 27, 2016 - Jan 12, 2017
#8	-12.77% Feb 16, 2021 - Mar 2, 2021	-21.05% Mar 21, 2019 - Jul 31, 2019
#9	-12.03% Apr 17, 2026 - Jun 11, 2026	-17.93% Mar 1, 2021 - Apr 28, 2021
#10	-11.53% Aug 19, 2016 - Aug 31, 2016	-17.27% Jul 27, 2016 - Sep 14, 2016
#11	-9.62% Jun 8, 2021 - Jun 11, 2021	-11.05% Mar 2, 2017 - Mar 16, 2017
#12	-8.53% Aug 27, 2025 - Sep 18, 2025	-10.99% Feb 28, 2019 - Mar 19, 2019
#13	-7.43% Mar 31, 2026 - Apr 15, 2026	-10.31% Jun 25, 2015 - Jul 17, 2015
#14	-7.20% Jun 14, 2021 - Jun 16, 2021	-10.20% Aug 28, 2024 - Oct 29, 2024
#15	-6.02% Nov 26, 2025 - Dec 8, 2025	-9.60% Jul 16, 2024 - Aug 16, 2024