PTGX vs BIO

Comparison between Protagonist Therapeutics Inc (PTGX, Company) and Bio-Rad Laboratories Inc - Class A (BIO, Company).

Both PTGX and BIO are from the Healthcare sector.

5-Year PerformancePTGX has outperformed BIO, delivering a return of +23.2% compared to -14.9%

PTGX vs BIO - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	PTGX(COMPANY)	BIO(COMPANY)
Market Cap	$8.04B	$8.02B
Max Drawdown	85.79%	73.77%
Sharpe Ratio	1.77	0.62
5Y Beta	0.24	0.90
Industry	Biotechnology	Medical Devices
P/E Ratio	-68.02	-16.27
Forward P/E	25.97	33.22
5Y EPS CAGR	1.43%	N/A
Debt to Equity	0.00%	11.72%
Free Cash Flow Yield	-1.47%	4.45%

Market Cap

Winner

PTGX

$8.04B

BIO

$8.02B

Max Drawdown

PTGX

85.79%

Winner

BIO

73.77%

Sharpe Ratio

Winner

PTGX

1.77

BIO

0.62

5Y Beta

Winner

PTGX

0.24

BIO

0.90

Industry

PTGX

Biotechnology

BIO

Medical Devices

P/E Ratio

Winner

PTGX

-68.02

BIO

-16.27

Forward P/E

Winner

PTGX

25.97

BIO

33.22

5Y EPS CAGR

PTGX

1.43%

BIO

N/A

Debt to Equity

Winner

PTGX

0.00%

BIO

11.72%

Free Cash Flow Yield

PTGX

-1.47%

Winner

BIO

4.45%

PTGX vs BIO - Historical Returns

Returns include dividend reinvestment.

Period	PTGX	BIO
1 month	+41.18%	-2.98%
3 months	+26.83%	+6.08%
6 months	+50.97%	-2.70%
1 year	+159.66%	+18.50%
5 years(CAGR)	+23.21%	-14.93%
10 years(CAGR)	+27.73%	+7.58%
Max(CAGR)	+27.73%	+12.70%

Winner

PTGX

+41.18%

BIO

-2.98%

Winner

PTGX

+26.83%

BIO

+6.08%

Winner

PTGX

+50.97%

BIO

-2.70%

Winner

PTGX

+159.66%

BIO

+18.50%

5Y(CAGR)

Winner

PTGX

+23.21%

BIO

-14.93%

10Y(CAGR)

Winner

PTGX

+27.73%

BIO

+7.58%

Max(CAGR)

Winner

PTGX

+27.73%

BIO

+12.70%

PTGX vs BIO - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	PTGX	BIO
2026	+50.97%	-2.70%
2025	+124.06%	-7.10%
2024	+64.82%	+0.16%
2023	+112.71%	-23.56%
2022	-69.11%	-42.82%
2021	+74.49%	+31.34%
2020	+190.91%	+56.64%
2019	+2.32%	+62.24%
2018	-68.18%	-3.81%
2017	-1.79%	+30.48%
2016	+87.95%	+33.84%
2015	N/A	+15.21%
2014	N/A	-1.70%
2013	N/A	+15.03%
2012	N/A	+7.11%
2011	N/A	-8.81%
2010	N/A	+6.11%
2009	N/A	+29.53%
2008	N/A	-24.67%
2007	N/A	+26.03%
2006	N/A	+26.08%
2005	N/A	+14.47%
2004	N/A	-1.78%
2003	N/A	+50.93%
2002	N/A	+25.24%
2001	N/A	+97.20%
2000	N/A	+40.58%
1999	N/A	-4.57%

PTGX vs BIO Drawdown Comparison

The maximum drawdown for PTGX was -85.79%, occurring on Jun 13, 2022. Recovery took 882 trading sessions.

The maximum drawdown for BIO was -73.77%, occurring on Jun 2, 2025. This drawdown has not yet recovered.

The current BIO drawdown is -64.03%.

Rank	PTGX	BIO
#1	-85.79% Sep 1, 2021 - Mar 10, 2025	-73.77% Sep 2, 2021 - Jun 2, 2025
#2	-82.13% Dec 5, 2016 - Feb 16, 2021	-50.88% Aug 11, 2008 - Apr 14, 2010
#3	-31.58% Mar 11, 2025 - Aug 27, 2025	-35.37% Feb 29, 2000 - Nov 29, 2000
#4	-20.33% Oct 17, 2016 - Nov 10, 2016	-33.87% Jun 19, 2002 - May 20, 2003
#5	-19.04% Mar 19, 2021 - May 18, 2021	-32.52% Sep 4, 2018 - Aug 2, 2019
#6	-16.38% Dec 12, 2025 - Mar 9, 2026	-30.71% May 16, 2011 - Jan 9, 2014
#7	-15.52% Oct 10, 2025 - Nov 24, 2025	-28.28% May 3, 2010 - Feb 28, 2011
#8	-12.77% Feb 16, 2021 - Mar 2, 2021	-27.41% Nov 7, 2007 - Aug 11, 2008
#9	-12.03% Apr 17, 2026 - Jun 11, 2026	-25.09% Sep 4, 2001 - Oct 15, 2001
#10	-11.53% Aug 19, 2016 - Aug 31, 2016	-24.28% Dec 26, 2003 - Aug 2, 2005
#11	-9.62% Jun 8, 2021 - Jun 11, 2021	-22.79% Feb 1, 2007 - Sep 27, 2007
#12	-8.53% Aug 27, 2025 - Sep 18, 2025	-21.77% Feb 20, 2020 - Apr 16, 2020
#13	-7.43% Mar 31, 2026 - Apr 15, 2026	-21.10% Jan 31, 2001 - May 1, 2001
#14	-7.20% Jun 14, 2021 - Jun 16, 2021	-20.93% Jul 25, 2003 - Dec 26, 2003
#15	-6.02% Nov 26, 2025 - Dec 8, 2025	-20.38% Feb 20, 2014 - Mar 5, 2015