PRAX vs PTGX

Comparison between Praxis Precision Medicines Inc (PRAX, Company) and Protagonist Therapeutics Inc (PTGX, Company).

Both PRAX and PTGX are from the Healthcare sector.

5-Year PerformancePTGX has outperformed PRAX, delivering a return of +23.6% compared to +5.6%

PRAX vs PTGX - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	PRAX(COMPANY)	PTGX(COMPANY)
Market Cap	$8.69B	$8.70B
Max Drawdown	98.67%	85.79%
Sharpe Ratio	1.42	1.92
5Y Beta	0.92	0.26
Industry	Biotechnology	Biotechnology
P/E Ratio	-22.74	-73.60
Forward P/E	N/A	29.33
PEG Ratio	-0.12	0.00
5Y EPS CAGR	-18.18%	1.43%
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-3.25%	-1.36%
P/S Ratio	953.14	117.61
P/B Ratio	6.29	13.57

Market Cap

PRAX

$8.69B

Winner

PTGX

$8.70B

Max Drawdown

PRAX

98.67%

Winner

PTGX

85.79%

Sharpe Ratio

PRAX

1.42

Winner

PTGX

1.92

5Y Beta

PRAX

0.92

Winner

PTGX

0.26

Industry

PRAX

Biotechnology

PTGX

Biotechnology

P/E Ratio

PRAX

-22.74

Winner

PTGX

-73.60

Forward P/E

PRAX

N/A

PTGX

29.33

PEG Ratio

Winner

PRAX

-0.12

PTGX

0.00

5Y EPS CAGR

PRAX

-18.18%

Winner

PTGX

1.43%

Debt to Equity

PRAX

0.00%

PTGX

0.00%

Free Cash Flow Yield

PRAX

-3.25%

Winner

PTGX

-1.36%

P/S Ratio

PRAX

953.14

Winner

PTGX

117.61

P/B Ratio

Winner

PRAX

6.29

PTGX

13.57

PRAX vs PTGX - Historical Returns

Returns include dividend reinvestment.

Period	PRAX	PTGX
1 month	+5.58%	+13.84%
3 months	-2.18%	+31.97%
6 months	+3.43%	+62.97%
1 year	+464.72%	+149.92%
5 years(CAGR)	+5.57%	+23.57%
10 years(CAGR)	N/A	+27.92%
Max(CAGR)	-4.36%	+27.92%

PRAX

+5.58%

Winner

PTGX

+13.84%

PRAX

-2.18%

Winner

PTGX

+31.97%

PRAX

+3.43%

Winner

PTGX

+62.97%

Winner

PRAX

+464.72%

PTGX

+149.92%

5Y(CAGR)

PRAX

+5.57%

Winner

PTGX

+23.57%

10Y(CAGR)

PRAX

N/A

PTGX

+27.92%

Max(CAGR)

PRAX

-4.36%

Winner

PTGX

+27.92%

PRAX vs PTGX - Annual Returns (2016 - 2026)

Returns include dividend reinvestment.

Year	PRAX	PTGX
2026	+12.57%	+55.35%
2025	+270.65%	+124.06%
2024	+268.23%	+64.82%
2023	-42.20%	+112.71%
2022	-88.27%	-69.11%
2021	-63.60%	+74.49%
2020	+97.91%	+190.91%
2019	N/A	+2.32%
2018	N/A	-68.18%
2017	N/A	-1.79%
2016	N/A	+87.95%

PRAX vs PTGX Drawdown Comparison

The maximum drawdown for PRAX was -98.67%, occurring on Mar 30, 2023. This drawdown has not yet recovered.

The maximum drawdown for PTGX was -85.79%, occurring on Jun 13, 2022. Recovery took 882 trading sessions.

The current PRAX drawdown is -64.30%. The current PTGX drawdown is -3.89%.

Rank	PRAX	PTGX
#1	-98.67% Jan 7, 2021 - Mar 30, 2023	-85.79% Sep 1, 2021 - Mar 10, 2025
#2	-21.78% Nov 9, 2020 - Nov 25, 2020	-82.13% Dec 5, 2016 - Feb 16, 2021
#3	-8.01% Dec 28, 2020 - Jan 6, 2021	-31.58% Mar 11, 2025 - Aug 27, 2025
#4	-7.00% Dec 11, 2020 - Dec 21, 2020	-20.33% Oct 17, 2016 - Nov 10, 2016
#5	-6.29% Oct 30, 2020 - Nov 9, 2020	-19.04% Mar 19, 2021 - May 18, 2021
#6	-4.48% Dec 2, 2020 - Dec 7, 2020	-16.38% Dec 12, 2025 - Mar 9, 2026
#7	-3.94% Dec 7, 2020 - Dec 11, 2020	-15.52% Oct 10, 2025 - Nov 24, 2025
#8	-3.16% Oct 22, 2020 - Oct 28, 2020	-12.77% Feb 16, 2021 - Mar 2, 2021
#9	-1.98% Oct 16, 2020 - Oct 21, 2020	-12.03% Apr 17, 2026 - Jun 11, 2026
#10	-1.50% Dec 23, 2020 - Dec 28, 2020	-11.53% Aug 19, 2016 - Aug 31, 2016
#11	N/A	-9.62% Jun 8, 2021 - Jun 11, 2021
#12	N/A	-8.53% Aug 27, 2025 - Sep 18, 2025
#13	N/A	-7.78% Jul 7, 2026 - Jul 17, 2026
#14	N/A	-7.43% Mar 31, 2026 - Apr 15, 2026
#15	N/A	-7.20% Jun 14, 2021 - Jun 16, 2021