PALI vs CIO

Comparison between Palisade Bio Inc (PALI, Company) and CITY OFFICE REIT, INC. (CIO, Company).

PALI is from the Healthcare sector, while CIO is from the Real Estate sector.

5-Year PerformanceCIO has outperformed PALI, delivering a return of +0.4% compared to -77.7%

PALI vs CIO - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	PALI(COMPANY)	CIO(COMPANY)
Market Cap	$281M	$282M
Max Drawdown	100.00%	83.69%
Sharpe Ratio	1.32	0.95
5Y Beta	0.00	N/A
Industry	Biotechnology	Reit - Office
P/E Ratio	-9.72	-2.32
Forward P/E	N/A	384.62
PEG Ratio	N/A	-0.00
Dividend Yield	N/A	4.29%
5Y Dividends CAGR	N/A	-13.03%
Debt to Equity	0.00%	65.30%
Free Cash Flow Yield	-4.41%	16.87%
P/S Ratio	11.78	N/A
P/B Ratio	2.29	N/A

Market Cap

PALI

$281M

Winner

CIO

$282M

Max Drawdown

PALI

100.00%

Winner

CIO

83.69%

Sharpe Ratio

Winner

PALI

1.32

CIO

0.95

5Y Beta

PALI

0.00

CIO

N/A

Industry

PALI

Biotechnology

CIO

Reit - Office

P/E Ratio

Winner

PALI

-9.72

CIO

-2.32

Forward P/E

PALI

N/A

CIO

384.62

PEG Ratio

PALI

N/A

CIO

-0.00

Dividend Yield

PALI

N/A

CIO

4.29%

5Y Dividends CAGR

PALI

N/A

CIO

-13.03%

Debt to Equity

Winner

PALI

0.00%

CIO

65.30%

Free Cash Flow Yield

PALI

-4.41%

Winner

CIO

16.87%

P/S Ratio

PALI

11.78

CIO

N/A

P/B Ratio

PALI

2.29

CIO

N/A

PALI vs CIO - Historical Returns

Returns include dividend reinvestment.

Period	PALI	CIO
1 month	-10.94%	+0.58%
3 months	-15.76%	+0.43%
6 months	-11.86%	+27.71%
1 year	+147.83%	+37.94%
5 years(CAGR)	-77.66%	+0.37%
10 years(CAGR)	-70.76%	+1.63%
Max(CAGR)	-51.59%	+2.20%

PALI

-10.94%

Winner

CIO

+0.58%

PALI

-15.76%

Winner

CIO

+0.43%

PALI

-11.86%

Winner

CIO

+27.71%

Winner

PALI

+147.83%

CIO

+37.94%

5Y(CAGR)

PALI

-77.66%

Winner

CIO

+0.37%

10Y(CAGR)

PALI

-70.76%

Winner

CIO

+1.63%

Max(CAGR)

PALI

-51.59%

Winner

CIO

+2.20%

PALI vs CIO - Annual Returns (2006 - 2026)

Returns include dividend reinvestment.

Year	PALI	CIO
2026	-31.60%	+0.14%
2025	+26.34%	+36.42%
2024	-81.00%	-5.33%
2023	-84.55%	-20.35%
2022	-93.11%	-55.54%
2021	-78.96%	+117.79%
2020	-20.00%	-20.68%
2019	-84.99%	+41.86%
2018	-84.58%	-14.64%
2017	-57.46%	+4.93%
2016	-73.46%	+15.61%
2015	-63.35%	-0.04%
2014	-13.92%	+8.52%
2013	+140.50%	N/A
2012	+9.00%	N/A
2011	-55.53%	N/A
2010	+14.59%	N/A
2009	+7.19%	N/A
2008	-55.00%	N/A
2007	+48.02%	N/A
2006	+50.00%	N/A

PALI vs CIO Drawdown Comparison

The maximum drawdown for PALI was -100.00%, occurring on Sep 10, 2025. This drawdown has not yet recovered.

The maximum drawdown for CIO was -80.90%, occurring on Oct 27, 2023. This drawdown has not yet recovered.

The current PALI drawdown is -100.00%. The current CIO drawdown is -56.00%.

Rank	PALI	CIO
#1	-100.00% Apr 9, 2014 - Sep 10, 2025	-80.90% Jan 6, 2022 - Oct 27, 2023
#2	-88.86% Apr 26, 2007 - Mar 17, 2014	-52.69% Feb 18, 2020 - Jul 26, 2021
#3	-24.62% Jan 10, 2007 - Mar 26, 2007	-24.56% Oct 5, 2017 - Jul 5, 2018
#4	-18.87% Mar 20, 2014 - Apr 9, 2014	-21.53% Apr 7, 2015 - Mar 18, 2016
#5	-16.00% Dec 29, 2006 - Jan 10, 2007	-21.53% Aug 28, 2018 - Jun 13, 2019
#6	-16.00% Dec 21, 2006 - Dec 29, 2006	-15.24% Oct 26, 2021 - Dec 22, 2021
#7	-7.58% Mar 26, 2007 - Apr 13, 2007	-13.83% Mar 18, 2016 - Jun 30, 2016
#8	-5.95% Mar 17, 2014 - Mar 20, 2014	-13.15% Aug 1, 2016 - Aug 31, 2017
#9	-5.63% Apr 18, 2007 - Apr 26, 2007	-11.77% Sep 26, 2019 - Jan 21, 2020
#10	N/A	-8.03% Jun 16, 2014 - Jul 10, 2014
#11	N/A	-7.34% Oct 14, 2014 - Apr 2, 2015
#12	N/A	-6.37% Jun 20, 2019 - Jul 30, 2019
#13	N/A	-5.00% Sep 7, 2021 - Sep 22, 2021
#14	N/A	-4.86% Jul 11, 2014 - Aug 27, 2014
#15	N/A	-4.43% Aug 27, 2014 - Sep 19, 2014