PALI vs BCYC

Comparison between Palisade Bio Inc (PALI, Company) and Bicycle Therapeutics Plc (BCYC, Company).

Both PALI and BCYC are from the Healthcare sector.

5-Year PerformanceBCYC has outperformed PALI, delivering a return of -32.7% compared to -77.7%

PALI vs BCYC - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	PALI(COMPANY)	BCYC(COMPANY)
Market Cap	$281M	$281M
Max Drawdown	100.00%	93.41%
Sharpe Ratio	1.31	-1.27
5Y Beta	0.00	1.28
Industry	Biotechnology	Biotechnology
P/E Ratio	-9.72	-1.28
PEG Ratio	N/A	-0.18
5Y EPS CAGR	N/A	11.06%
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-4.41%	-82.48%
P/S Ratio	11.78	4.43
P/B Ratio	2.29	0.51

Market Cap

Winner

PALI

$281M

BCYC

$281M

Max Drawdown

PALI

100.00%

Winner

BCYC

93.41%

Sharpe Ratio

Winner

PALI

1.31

BCYC

-1.27

5Y Beta

Winner

PALI

0.00

BCYC

1.28

Industry

PALI

Biotechnology

BCYC

Biotechnology

P/E Ratio

Winner

PALI

-9.72

BCYC

-1.28

PEG Ratio

PALI

N/A

BCYC

-0.18

5Y EPS CAGR

PALI

N/A

BCYC

11.06%

Debt to Equity

PALI

0.00%

BCYC

0.00%

Free Cash Flow Yield

Winner

PALI

-4.41%

BCYC

-82.48%

P/S Ratio

PALI

11.78

Winner

BCYC

4.43

P/B Ratio

PALI

2.29

Winner

BCYC

0.51

PALI vs BCYC - Historical Returns

Returns include dividend reinvestment.

Period	PALI	BCYC
1 month	-7.65%	-6.74%
3 months	-15.08%	-17.82%
6 months	-6.63%	-43.38%
1 year	+175.69%	-48.38%
5 years(CAGR)	-77.65%	-32.70%
10 years(CAGR)	-70.80%	N/A
Max(CAGR)	-51.60%	-13.96%

PALI

-7.65%

Winner

BCYC

-6.74%

Winner

PALI

-15.08%

BCYC

-17.82%

Winner

PALI

-6.63%

BCYC

-43.38%

Winner

PALI

+175.69%

BCYC

-48.38%

5Y(CAGR)

PALI

-77.65%

Winner

BCYC

-32.70%

10Y(CAGR)

PALI

-70.80%

BCYC

N/A

Max(CAGR)

PALI

-51.60%

Winner

BCYC

-13.96%

PALI vs BCYC - Annual Returns (2006 - 2026)

Returns include dividend reinvestment.

Year	PALI	BCYC
2026	-32.40%	-37.87%
2025	+26.34%	-50.70%
2024	-81.00%	-24.08%
2023	-84.55%	-39.73%
2022	-93.11%	-50.25%
2021	-78.96%	+217.03%
2020	-20.00%	+82.79%
2019	-84.99%	-21.42%
2018	-84.58%	N/A
2017	-57.46%	N/A
2016	-73.46%	N/A
2015	-63.35%	N/A
2014	-13.92%	N/A
2013	+140.50%	N/A
2012	+9.00%	N/A
2011	-55.53%	N/A
2010	+14.59%	N/A
2009	+7.19%	N/A
2008	-55.00%	N/A
2007	+48.02%	N/A
2006	+50.00%	N/A

PALI vs BCYC Drawdown Comparison

The maximum drawdown for PALI was -100.00%, occurring on Sep 10, 2025. This drawdown has not yet recovered.

The maximum drawdown for BCYC was -93.41%, occurring on Jun 10, 2026. This drawdown has not yet recovered.

The current PALI drawdown is -100.00%. The current BCYC drawdown is -93.21%.

Rank	PALI	BCYC
#1	-100.00% Apr 9, 2014 - Sep 10, 2025	-93.41% Nov 15, 2021 - Jun 10, 2026
#2	-88.86% Apr 26, 2007 - Mar 17, 2014	-53.96% Jun 19, 2019 - Feb 14, 2020
#3	-24.62% Jan 10, 2007 - Mar 26, 2007	-41.61% Mar 10, 2020 - May 28, 2020
#4	-18.87% Mar 20, 2014 - Apr 9, 2014	-25.95% Feb 5, 2021 - Apr 1, 2021
#5	-16.00% Dec 29, 2006 - Jan 10, 2007	-20.84% Jul 23, 2021 - Aug 30, 2021
#6	-16.00% Dec 21, 2006 - Dec 29, 2006	-18.83% Feb 26, 2020 - Mar 4, 2020
#7	-7.58% Mar 26, 2007 - Apr 13, 2007	-18.70% Jul 15, 2020 - Sep 16, 2020
#8	-5.95% Mar 17, 2014 - Mar 20, 2014	-16.36% Apr 8, 2021 - Jul 13, 2021
#9	-5.63% Apr 18, 2007 - Apr 26, 2007	-15.98% Jun 8, 2020 - Jul 14, 2020
#10	N/A	-15.96% Nov 30, 2020 - Jan 14, 2021
#11	N/A	-15.70% Mar 4, 2020 - Mar 10, 2020
#12	N/A	-14.32% Jan 19, 2021 - Feb 5, 2021
#13	N/A	-14.18% May 24, 2019 - Jun 14, 2019
#14	N/A	-13.83% Oct 14, 2021 - Nov 15, 2021
#15	N/A	-12.02% Sep 21, 2020 - Nov 17, 2020