ORKA vs DNLI

Comparison between ARCA biopharma Inc (ORKA, Company) and Denali Therapeutics Inc (DNLI, Company).

Both ORKA and DNLI are from the Healthcare sector.

5-Year PerformanceORKA has outperformed DNLI, delivering a return of +26.4% compared to -18.7%

ORKA vs DNLI - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	ORKA(COMPANY)	DNLI(COMPANY)
Market Cap	$4.23B	$4.23B
Max Drawdown	100.00%	87.74%
Sharpe Ratio	2.68	1.17
5Y Beta	0.00	1.50
Industry	Biotechnology	Biotechnology
P/E Ratio	-33.45	-7.97
PEG Ratio	N/A	-1.24
5Y EPS CAGR	11.91%	N/A
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-2.15%	-9.97%
P/S Ratio	N/A	3643.65
P/B Ratio	10.62	4.43

Market Cap

ORKA

$4.23B

Winner

DNLI

$4.23B

Max Drawdown

ORKA

100.00%

Winner

DNLI

87.74%

Sharpe Ratio

Winner

ORKA

2.68

DNLI

1.17

5Y Beta

Winner

ORKA

0.00

DNLI

1.50

Industry

ORKA

Biotechnology

DNLI

Biotechnology

P/E Ratio

Winner

ORKA

-33.45

DNLI

-7.97

PEG Ratio

ORKA

N/A

DNLI

-1.24

5Y EPS CAGR

ORKA

11.91%

DNLI

N/A

Debt to Equity

ORKA

0.00%

DNLI

0.00%

Free Cash Flow Yield

Winner

ORKA

-2.15%

DNLI

-9.97%

P/S Ratio

ORKA

N/A

DNLI

3643.65

P/B Ratio

ORKA

10.62

Winner

DNLI

4.43

ORKA vs DNLI - Historical Returns

Returns include dividend reinvestment.

Period	ORKA	DNLI
1 month	+35.55%	+24.60%
3 months	+45.67%	+33.54%
6 months	+211.52%	+50.35%
1 year	+516.84%	+67.30%
5 years(CAGR)	+26.44%	-18.68%
10 years(CAGR)	-14.16%	+2.12%
Max(CAGR)	-28.21%	+2.12%

Winner

ORKA

+35.55%

DNLI

+24.60%

Winner

ORKA

+45.67%

DNLI

+33.54%

Winner

ORKA

+211.52%

DNLI

+50.35%

Winner

ORKA

+516.84%

DNLI

+67.30%

5Y(CAGR)

Winner

ORKA

+26.44%

DNLI

-18.68%

10Y(CAGR)

ORKA

-14.16%

Winner

DNLI

+2.12%

Max(CAGR)

ORKA

-28.21%

Winner

DNLI

+2.12%

ORKA vs DNLI - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	ORKA	DNLI
2026	+207.00%	+57.84%
2025	+51.78%	-20.78%
2024	+58.42%	-4.72%
2023	-29.75%	-22.33%
2022	+3.04%	-41.17%
2021	-48.32%	-37.06%
2020	-29.40%	+411.04%
2019	-3.87%	-9.88%
2018	-75.30%	+28.08%
2017	-50.18%	-27.09%
2016	-38.58%	N/A
2015	-36.13%	N/A
2014	-44.88%	N/A
2013	-31.71%	N/A
2012	-62.00%	N/A
2011	-68.25%	N/A
2010	-3.35%	N/A
2009	-49.06%	N/A
2008	-82.58%	N/A
2007	-51.72%	N/A
2006	-52.73%	N/A
2005	-17.66%	N/A
2004	+173.61%	N/A
2003	+321.69%	N/A
2002	-89.30%	N/A
2001	-47.20%	N/A
2000	-7.99%	N/A
1999	+209.27%	N/A

ORKA vs DNLI Drawdown Comparison

The maximum drawdown for ORKA was -100.00%, occurring on Apr 8, 2025. This drawdown has not yet recovered.

The maximum drawdown for DNLI was -87.74%, occurring on Apr 8, 2025. This drawdown has not yet recovered.

The current ORKA drawdown is -100.00%. The current DNLI drawdown is -72.55%.

Rank	ORKA	DNLI
#1	-100.00% Feb 18, 2000 - Apr 8, 2025	-87.74% Dec 22, 2020 - Apr 8, 2025
#2	-33.40% Jan 10, 2000 - Jan 24, 2000	-49.76% Feb 16, 2018 - Apr 2, 2019
#3	-23.62% Jan 25, 2000 - Feb 2, 2000	-49.54% Apr 10, 2019 - Jun 2, 2020
#4	-21.89% Dec 13, 1999 - Dec 27, 1999	-29.88% Dec 8, 2017 - Jan 22, 2018
#5	-16.91% Nov 1, 1999 - Nov 17, 1999	-19.74% Jun 3, 2020 - Aug 6, 2020
#6	-13.78% Dec 29, 1999 - Jan 6, 2000	-19.58% Jan 29, 2018 - Feb 16, 2018
#7	-7.08% Dec 7, 1999 - Dec 10, 1999	-13.33% Nov 12, 2020 - Dec 4, 2020
#8	-6.17% Nov 26, 1999 - Dec 2, 1999	-11.16% Aug 10, 2020 - Aug 25, 2020
#9	-5.92% Dec 2, 1999 - Dec 7, 1999	-10.43% Sep 17, 2020 - Oct 7, 2020
#10	-5.42% Nov 22, 1999 - Nov 26, 1999	-10.33% Oct 13, 2020 - Oct 27, 2020
#11	-5.14% Feb 3, 2000 - Feb 8, 2000	-9.64% Aug 25, 2020 - Sep 14, 2020
#12	-3.52% Feb 8, 2000 - Feb 10, 2000	-7.28% Oct 28, 2020 - Nov 4, 2020
#13	-3.34% Feb 10, 2000 - Feb 15, 2000	-3.20% Jan 23, 2018 - Jan 26, 2018
#14	N/A	-2.37% Apr 3, 2019 - Apr 5, 2019
#15	N/A	-1.33% Dec 16, 2020 - Dec 18, 2020