OBIO vs CDXS

Comparison between Orchestra BioMed Holdings Inc (OBIO, Company) and Codexis Inc (CDXS, Company).

Both OBIO and CDXS are from the Healthcare sector.

5-Year PerformanceOBIO has outperformed CDXS, delivering a return of -17.4% compared to -35.0%

OBIO vs CDXS - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	OBIO(COMPANY)	CDXS(COMPANY)
Market Cap	$234M	$234M
Max Drawdown	89.40%	97.65%
Sharpe Ratio	0.54	0.53
5Y Beta	1.64	1.83
Industry	Biotechnology	Biotechnology
P/E Ratio	-3.58	-7.26
Forward P/E	N/A	149.25
5Y EPS CAGR	N/A	-2.98%
Debt to Equity	36.41%	93.64%
Free Cash Flow Yield	-23.54%	-9.47%

Market Cap

Winner

OBIO

$234M

CDXS

$234M

Max Drawdown

Winner

OBIO

89.40%

CDXS

97.65%

Sharpe Ratio

Winner

OBIO

0.54

CDXS

0.53

5Y Beta

Winner

OBIO

1.64

CDXS

1.83

Industry

OBIO

Biotechnology

CDXS

Biotechnology

P/E Ratio

OBIO

-3.58

Winner

CDXS

-7.26

Forward P/E

OBIO

N/A

CDXS

149.25

5Y EPS CAGR

OBIO

N/A

CDXS

-2.98%

Debt to Equity

Winner

OBIO

36.41%

CDXS

93.64%

Free Cash Flow Yield

OBIO

-23.54%

Winner

CDXS

-9.47%

OBIO vs CDXS - Historical Returns

Returns include dividend reinvestment.

Period	OBIO	CDXS
1 month	+0.25%	+0.78%
3 months	-11.53%	+74.83%
6 months	-8.06%	+56.71%
1 year	+33.44%	+9.36%
5 years(CAGR)	-17.44%	-34.99%
10 years(CAGR)	N/A	-4.75%
Max(CAGR)	-16.38%	-9.66%

OBIO

+0.25%

Winner

CDXS

+0.78%

OBIO

-11.53%

Winner

CDXS

+74.83%

OBIO

-8.06%

Winner

CDXS

+56.71%

Winner

OBIO

+33.44%

CDXS

+9.36%

5Y(CAGR)

Winner

OBIO

-17.44%

CDXS

-34.99%

10Y(CAGR)

OBIO

N/A

CDXS

-4.75%

Max(CAGR)

OBIO

-16.38%

Winner

CDXS

-9.66%

OBIO vs CDXS - Annual Returns (2010 - 2026)

Returns include dividend reinvestment.

Year	OBIO	CDXS
2026	-7.42%	+59.63%
2025	-22.86%	-67.40%
2024	-54.44%	+52.88%
2023	-9.06%	-34.69%
2022	+0.71%	-85.41%
2021	-22.46%	+45.92%
2020	+12.37%	+32.95%
2019	N/A	-0.74%
2018	N/A	+104.91%
2017	N/A	+85.56%
2016	N/A	+9.00%
2015	N/A	+51.61%
2014	N/A	+76.22%
2013	N/A	-45.10%
2012	N/A	-59.67%
2011	N/A	-49.62%
2010	N/A	-20.06%

OBIO vs CDXS Drawdown Comparison

The maximum drawdown for OBIO was -89.40%, occurring on Sep 23, 2025. This drawdown has not yet recovered.

The maximum drawdown for CDXS was -97.65%, occurring on Mar 3, 2026. This drawdown has not yet recovered.

The current OBIO drawdown is -82.01%. The current CDXS drawdown is -93.85%.

Rank	OBIO	CDXS
#1	-89.40% Apr 12, 2023 - Sep 23, 2025	-97.65% Nov 8, 2021 - Mar 3, 2026
#2	-42.60% Feb 16, 2021 - Mar 6, 2023	-91.35% Apr 26, 2010 - May 30, 2018
#3	-33.00% Mar 6, 2023 - Mar 31, 2023	-61.10% Dec 3, 2018 - Dec 22, 2020
#4	-14.37% Aug 6, 2020 - Dec 30, 2020	-39.31% Feb 8, 2021 - Oct 7, 2021
#5	-13.31% Dec 30, 2020 - Feb 8, 2021	-26.39% Sep 25, 2018 - Nov 28, 2018
#6	-5.52% Mar 31, 2023 - Apr 5, 2023	-18.84% Jun 20, 2018 - Aug 27, 2018
#7	-1.63% Apr 5, 2023 - Apr 11, 2023	-16.02% Jan 19, 2021 - Feb 2, 2021
#8	-0.53% Feb 8, 2021 - Feb 10, 2021	-14.76% Oct 8, 2021 - Oct 26, 2021
#9	N/A	-9.91% Dec 22, 2020 - Jan 8, 2021
#10	N/A	-7.42% Jun 7, 2018 - Jun 19, 2018
#11	N/A	-4.92% Jan 8, 2021 - Jan 14, 2021
#12	N/A	-4.77% Sep 13, 2018 - Sep 25, 2018
#13	N/A	-3.59% Oct 28, 2021 - Nov 4, 2021
#14	N/A	-3.04% Aug 27, 2018 - Sep 5, 2018
#15	N/A	-2.33% Jun 1, 2018 - Jun 7, 2018