NICE vs SYRE

Comparison between NICE Ltd (NICE, Company) and Spyre Therapeutics Inc (SYRE, Company).

NICE is from the Technology sector, while SYRE is from the Healthcare sector.

5-Year PerformanceNICE has outperformed SYRE, delivering a return of -16.0% compared to -16.9%

NICE vs SYRE - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	NICE(COMPANY)	SYRE(COMPANY)
Market Cap	$5.67B	$5.67B
Max Drawdown	93.23%	99.11%
Sharpe Ratio	-0.97	2.60
5Y Beta	0.78	1.75
Industry	Software - Application	Biotechnology
P/E Ratio	9.26	-29.14
Forward P/E	8.10	N/A
PEG Ratio	0.20	N/A
5Y EPS CAGR	26.56%	-2.15%
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	12.31%	-3.27%

Market Cap

NICE

$5.67B

Winner

SYRE

$5.67B

Max Drawdown

Winner

NICE

93.23%

SYRE

99.11%

Sharpe Ratio

NICE

-0.97

Winner

SYRE

2.60

5Y Beta

Winner

NICE

0.78

SYRE

1.75

Industry

NICE

Software - Application

SYRE

Biotechnology

P/E Ratio

NICE

9.26

Winner

SYRE

-29.14

Forward P/E

NICE

8.10

SYRE

N/A

PEG Ratio

NICE

0.20

SYRE

N/A

5Y EPS CAGR

Winner

NICE

26.56%

SYRE

-2.15%

Debt to Equity

NICE

0.00%

SYRE

0.00%

Free Cash Flow Yield

Winner

NICE

12.31%

SYRE

-3.27%

NICE vs SYRE - Historical Returns

Returns include dividend reinvestment.

Period	NICE	SYRE
1 month	-11.14%	-2.00%
3 months	-20.32%	+66.44%
6 months	-5.85%	+206.43%
1 year	-43.67%	+367.01%
5 years(CAGR)	-15.96%	-16.95%
10 years(CAGR)	+3.92%	-9.09%
Max(CAGR)	+7.17%	-11.38%

NICE

-11.14%

Winner

SYRE

-2.00%

NICE

-20.32%

Winner

SYRE

+66.44%

NICE

-5.85%

Winner

SYRE

+206.43%

NICE

-43.67%

Winner

SYRE

+367.01%

5Y(CAGR)

Winner

NICE

-15.96%

SYRE

-16.95%

10Y(CAGR)

Winner

NICE

+3.92%

SYRE

-9.09%

Max(CAGR)

Winner

NICE

+7.17%

SYRE

-11.38%

NICE vs SYRE - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	NICE	SYRE
2026	-16.23%	+135.19%
2025	-33.36%	+37.36%
2024	-11.89%	+8.79%
2023	+4.43%	+104.27%
2022	-34.89%	-90.57%
2021	+8.88%	-44.51%
2020	+78.75%	+1.55%
2019	+45.20%	-4.98%
2018	+17.38%	+39.22%
2017	+34.21%	+18.38%
2016	+22.39%	-55.48%
2015	+15.20%	N/A
2014	+27.72%	N/A
2013	+18.34%	N/A
2012	-3.32%	N/A
2011	-3.47%	N/A
2010	+10.03%	N/A
2009	+32.54%	N/A
2008	-32.52%	N/A
2007	+14.10%	N/A
2006	+25.42%	N/A
2005	+55.66%	N/A
2004	+30.21%	N/A
2003	+203.59%	N/A
2002	-52.64%	N/A
2001	-2.57%	N/A
2000	-60.47%	N/A
1999	+58.01%	N/A

NICE vs SYRE Drawdown Comparison

The maximum drawdown for NICE was -93.23%, occurring on Oct 14, 2002. Recovery took 3713 trading sessions.

The maximum drawdown for SYRE was -99.11%, occurring on Jun 21, 2023. This drawdown has not yet recovered.

The current NICE drawdown is -70.23%. The current SYRE drawdown is -76.01%.

Rank	NICE	SYRE
#1	-93.23% Mar 1, 2000 - Dec 3, 2014	-99.11% Apr 8, 2016 - Jun 21, 2023
#2	-72.58% Nov 15, 2021 - May 13, 2026	N/A
#3	-35.23% Feb 20, 2020 - May 22, 2020	N/A
#4	-24.40% Dec 31, 2020 - Jul 22, 2021	N/A
#5	-21.90% Jun 10, 2015 - Jul 28, 2016	N/A
#6	-15.18% Jan 19, 2000 - Feb 8, 2000	N/A
#7	-14.71% Nov 12, 1999 - Dec 9, 1999	N/A
#8	-13.35% Sep 14, 2018 - Feb 25, 2019	N/A
#9	-12.20% Sep 9, 2021 - Nov 11, 2021	N/A
#10	-10.07% Aug 26, 2020 - Oct 12, 2020	N/A
#11	-9.01% Jan 12, 2018 - Feb 21, 2018	N/A
#12	-8.87% Jul 23, 2021 - Aug 24, 2021	N/A
#13	-8.87% Jan 3, 2000 - Jan 10, 2000	N/A
#14	-8.31% Nov 5, 2020 - Dec 16, 2020	N/A
#15	-8.29% Jun 6, 2017 - Sep 18, 2017	N/A