MDGL vs AGNC

Comparison between Madrigal Pharmaceuticals Inc (MDGL, Company) and AGNC Investment Corp (AGNC, Company).

MDGL is from the Healthcare sector, while AGNC is from the Real Estate sector.

5-Year PerformanceMDGL has outperformed AGNC, delivering a return of +31.3% compared to +3.1%

MDGL vs AGNC - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	MDGL(COMPANY)	AGNC(COMPANY)
Market Cap	$12B	$12B
Max Drawdown	98.40%	81.08%
Sharpe Ratio	1.33	1.75
5Y Beta	0.73	0.67
Industry	Biotechnology	Reit - Mortgage
P/E Ratio	-39.71	8.00
Forward P/E	666.67	6.74
PEG Ratio	0.00	0.05
Dividend Yield	N/A	13.40%
5Y Dividends CAGR	N/A	1.61%
5Y EPS CAGR	23.26%	-25.22%
Debt to Equity	62.62%	0.00%
Free Cash Flow Yield	-2.20%	6.85%
P/S Ratio	10.99	7.72
P/B Ratio	19.84	1.20

Market Cap

Winner

MDGL

$12B

AGNC

$12B

Max Drawdown

MDGL

98.40%

Winner

AGNC

81.08%

Sharpe Ratio

MDGL

1.33

Winner

AGNC

1.75

5Y Beta

MDGL

0.73

Winner

AGNC

0.67

Industry

MDGL

Biotechnology

AGNC

Reit - Mortgage

P/E Ratio

Winner

MDGL

-39.71

AGNC

8.00

Forward P/E

MDGL

666.67

Winner

AGNC

6.74

PEG Ratio

Winner

MDGL

0.00

AGNC

0.05

Dividend Yield

MDGL

N/A

AGNC

13.40%

5Y Dividends CAGR

MDGL

N/A

AGNC

1.61%

5Y EPS CAGR

Winner

MDGL

23.26%

AGNC

-25.22%

Debt to Equity

MDGL

62.62%

Winner

AGNC

0.00%

Free Cash Flow Yield

MDGL

-2.20%

Winner

AGNC

6.85%

P/S Ratio

MDGL

10.99

Winner

AGNC

7.72

P/B Ratio

MDGL

19.84

Winner

AGNC

1.20

MDGL vs AGNC - Historical Returns

Returns include dividend reinvestment.

Period	MDGL	AGNC
1 month	-1.87%	+6.38%
3 months	+4.46%	-0.98%
6 months	+4.25%	+12.23%
1 year	+70.26%	+40.91%
5 years(CAGR)	+31.34%	+3.10%
10 years(CAGR)	+44.03%	+6.97%
Max(CAGR)	+2.48%	+11.62%

MDGL

-1.87%

Winner

AGNC

+6.38%

Winner

MDGL

+4.46%

AGNC

-0.98%

MDGL

+4.25%

Winner

AGNC

+12.23%

Winner

MDGL

+70.26%

AGNC

+40.91%

5Y(CAGR)

Winner

MDGL

+31.34%

AGNC

+3.10%

10Y(CAGR)

Winner

MDGL

+44.03%

AGNC

+6.97%

Max(CAGR)

MDGL

+2.48%

Winner

AGNC

+11.62%

MDGL vs AGNC - Annual Returns (2007 - 2026)

Returns include dividend reinvestment.

Year	MDGL	AGNC
2026	-14.12%	+3.81%
2025	+85.59%	+33.83%
2024	+36.02%	+10.58%
2023	-18.93%	+8.86%
2022	+222.07%	-23.81%
2021	-22.80%	+6.67%
2020	+22.60%	-2.19%
2019	-18.06%	+12.74%
2018	+15.71%	-1.28%
2017	+475.13%	+20.77%
2016	+28.97%	+15.72%
2015	-87.74%	-11.87%
2014	-49.62%	+26.43%
2013	-45.64%	-25.71%
2012	+84.46%	+19.74%
2011	-24.56%	+18.83%
2010	+10.87%	+31.30%
2009	-17.99%	+56.39%
2008	-3.62%	+25.51%
2007	-26.29%	N/A

MDGL vs AGNC Drawdown Comparison

The maximum drawdown for MDGL was -98.40%, occurring on Feb 11, 2016. Recovery took 3162 trading sessions.

The maximum drawdown for AGNC was -54.54%, occurring on Oct 10, 2022. Recovery took 1109 trading sessions.

The current MDGL drawdown is -15.39%. The current AGNC drawdown is -6.76%.

Rank	MDGL	AGNC
#1	-98.40% Jan 28, 2013 - Aug 22, 2025	-54.54% Jun 8, 2021 - Nov 5, 2025
#2	-87.64% Oct 5, 2007 - Jan 22, 2013	-51.76% Feb 20, 2020 - Apr 16, 2021
#3	-51.43% Jun 4, 2007 - Oct 4, 2007	-37.29% Apr 30, 2013 - Apr 4, 2017
#4	-29.36% Dec 22, 2025 - Mar 3, 2026	-31.04% Dec 31, 2008 - Jun 9, 2009
#5	-18.88% Feb 9, 2007 - Jun 4, 2007	-28.81% May 16, 2008 - Sep 8, 2008
#6	-10.10% Sep 30, 2025 - Nov 5, 2025	-22.42% Sep 8, 2008 - Nov 4, 2008
#7	-9.42% Nov 26, 2025 - Dec 22, 2025	-18.99% Sep 17, 2012 - Mar 28, 2013
#8	-8.01% Sep 8, 2025 - Sep 30, 2025	-18.68% Jan 27, 2026 - Mar 27, 2026
#9	-4.91% Nov 11, 2025 - Nov 17, 2025	-15.90% Oct 17, 2017 - Nov 7, 2019
#10	-4.32% Jan 23, 2013 - Jan 25, 2013	-15.36% Sep 23, 2009 - Mar 22, 2010
#11	-3.02% Nov 18, 2025 - Nov 24, 2025	-11.69% Jul 6, 2011 - Dec 6, 2011
#12	-1.52% Aug 29, 2025 - Sep 8, 2025	-11.06% Nov 5, 2008 - Nov 25, 2008
#13	-0.59% Aug 22, 2025 - Aug 26, 2025	-10.94% Apr 29, 2010 - Jun 14, 2010
#14	N/A	-10.17% Dec 3, 2008 - Dec 19, 2008
#15	N/A	-7.92% Apr 27, 2017 - Jun 9, 2017