MDGL vs SPY
Comparison between Madrigal Pharmaceuticals Inc (MDGL, Company) and SPDR S&P 500 ETF Trust (SPY, ETF).
5-Year PerformanceMDGL has outperformed SPY, delivering a return of +31.3% compared to +13.3%
MDGL vs SPY - Performance Comparison
Key Characteristics
Financial metrics and valuation ratios
Market Cap / Net Assets
MDGL
$12B
Winner
SPY
$652B
Expense Ratio
MDGL
N/A
SPY
0.09%
Max Drawdown
MDGL
98.40%
Winner
SPY
56.47%
Sharpe Ratio
MDGL
1.33
Winner
SPY
2.07
5Y Beta
Winner
MDGL
0.73
SPY
1.00
Industry
MDGL
Biotechnology
SPY
N/A
P/E Ratio
Winner
MDGL
-39.71
SPY
28.24
Forward P/E
MDGL
666.67
Winner
SPY
21.85
PEG Ratio
MDGL
0.00
SPY
N/A
5Y Dividends CAGR
MDGL
N/A
SPY
5.43%
5Y EPS CAGR
MDGL
23.26%
Winner
SPY
25.79%
Debt to Equity
MDGL
62.62%
Winner
SPY
22.35%
Free Cash Flow Yield
MDGL
-2.20%
SPY
N/A
P/S Ratio
MDGL
10.99
Winner
SPY
3.55
P/B Ratio
MDGL
19.84
Winner
SPY
5.29
MDGL vs SPY - Historical Returns
Returns include dividend reinvestment.
1M
MDGL
-1.87%
Winner
SPY
+9.11%
3M
MDGL
+4.46%
Winner
SPY
+6.59%
6M
MDGL
+4.25%
Winner
SPY
+10.56%
1Y
Winner
MDGL
+70.26%
SPY
+32.04%
5Y(CAGR)
Winner
MDGL
+31.34%
SPY
+13.35%
10Y(CAGR)
Winner
MDGL
+44.03%
SPY
+15.49%
Max(CAGR)
MDGL
+2.48%
Winner
SPY
+8.50%
MDGL vs SPY - Annual Returns (1999 - 2026)
Returns include dividend reinvestment.
| Year | MDGL | SPY |
|---|---|---|
| 2026 | -14.12% | +8.27% |
| 2025 | +85.59% | +18.00% |
| 2024 | +36.02% | +25.59% |
| 2023 | -18.93% | +26.72% |
| 2022 | +222.07% | -18.64% |
| 2021 | -22.80% | +30.52% |
| 2020 | +22.60% | +17.28% |
| 2019 | -18.06% | +31.09% |
| 2018 | +15.71% | -5.24% |
| 2017 | +475.13% | +20.78% |
| 2016 | +28.97% | +13.59% |
| 2015 | -87.74% | +1.31% |
| 2014 | -49.62% | +14.56% |
| 2013 | -45.64% | +29.00% |
| 2012 | +84.46% | +14.17% |
| 2011 | -24.56% | +0.85% |
| 2010 | +10.87% | +13.14% |
| 2009 | -17.99% | +22.67% |
| 2008 | -3.62% | -36.25% |
| 2007 | -26.29% | +5.32% |
| 2006 | N/A | +13.85% |
| 2005 | N/A | +5.32% |
| 2004 | N/A | +10.75% |
| 2003 | N/A | +24.18% |
| 2002 | N/A | -22.42% |
| 2001 | N/A | -10.13% |
| 2000 | N/A | -8.84% |
| 1999 | N/A | +8.61% |
MDGL vs SPY Drawdown Comparison
The maximum drawdown for MDGL was -98.40%, occurring on Feb 11, 2016. Recovery took 3162 trading sessions.
The maximum drawdown for SPY was -55.20%, occurring on Mar 9, 2009. Recovery took 1224 trading sessions.
The current MDGL drawdown is -15.39%.
| Rank | MDGL | SPY |
|---|---|---|
| #1 | -98.40% Jan 28, 2013 - Aug 22, 2025 | -55.20% Oct 9, 2007 - Aug 16, 2012 |
| #2 | -87.64% Oct 5, 2007 - Jan 22, 2013 | -47.50% Mar 24, 2000 - Oct 26, 2006 |
| #3 | -51.43% Jun 4, 2007 - Oct 4, 2007 | -33.70% Feb 19, 2020 - Aug 10, 2020 |
| #4 | -29.36% Dec 22, 2025 - Mar 3, 2026 | -24.50% Jan 3, 2022 - Dec 13, 2023 |
| #5 | -18.88% Feb 9, 2007 - Jun 4, 2007 | -19.34% Sep 20, 2018 - Apr 12, 2019 |
| #6 | -10.10% Sep 30, 2025 - Nov 5, 2025 | -18.76% Feb 19, 2025 - Jun 26, 2025 |
| #7 | -9.42% Nov 26, 2025 - Dec 22, 2025 | -13.02% Jul 20, 2015 - Apr 18, 2016 |
| #8 | -8.01% Sep 8, 2025 - Sep 30, 2025 | -10.10% Jan 26, 2018 - Aug 6, 2018 |
| #9 | -4.91% Nov 11, 2025 - Nov 17, 2025 | -9.44% Sep 2, 2020 - Nov 11, 2020 |
| #10 | -4.32% Jan 23, 2013 - Jan 25, 2013 | -9.30% Jan 19, 2000 - Mar 17, 2000 |
| #11 | -3.02% Nov 18, 2025 - Nov 24, 2025 | -9.05% Jul 19, 2007 - Oct 5, 2007 |
| #12 | -1.52% Aug 29, 2025 - Sep 8, 2025 | -8.88% Jan 27, 2026 - Apr 14, 2026 |
| #13 | -0.59% Aug 22, 2025 - Aug 26, 2025 | -8.41% Jul 16, 2024 - Sep 19, 2024 |
| #14 | N/A | -7.35% Sep 14, 2012 - Jan 2, 2013 |
| #15 | N/A | -7.27% Sep 18, 2014 - Oct 31, 2014 |
Correlation
Correlation between MDGL and SPY is 0.41 which considered as a weak positive correlation - the stocks show a slight tendency to move together.
0.41
-101
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