MDGL vs ALGN

Comparison between Madrigal Pharmaceuticals Inc (MDGL, Company) and Align Technology Inc (ALGN, Company).

Both MDGL and ALGN are from the Healthcare sector.

5-Year PerformanceMDGL has outperformed ALGN, delivering a return of +43.0% compared to -23.5%

MDGL vs ALGN - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	MDGL(COMPANY)	ALGN(COMPANY)
Market Cap	$12B	$12B
Max Drawdown	98.40%	92.30%
Sharpe Ratio	0.83	0.65
5Y Beta	0.68	1.30
Industry	Biotechnology	Medical Instruments & Supplies
P/E Ratio	-37.76	30.08
Forward P/E	666.67	15.58
PEG Ratio	-3.48	0.83
5Y EPS CAGR	21.71%	-8.14%
Debt to Equity	65.07%	0.00%
Free Cash Flow Yield	-1.67%	5.11%
P/S Ratio	9.13	3.11
P/B Ratio	22.38	2.96

Market Cap

MDGL

$12B

Winner

ALGN

$12B

Max Drawdown

MDGL

98.40%

Winner

ALGN

92.30%

Sharpe Ratio

Winner

MDGL

0.83

ALGN

0.65

5Y Beta

Winner

MDGL

0.68

ALGN

1.30

Industry

MDGL

Biotechnology

ALGN

Medical Instruments & Supplies

P/E Ratio

Winner

MDGL

-37.76

ALGN

30.08

Forward P/E

MDGL

666.67

Winner

ALGN

15.58

PEG Ratio

Winner

MDGL

-3.48

ALGN

0.83

5Y EPS CAGR

Winner

MDGL

21.71%

ALGN

-8.14%

Debt to Equity

MDGL

65.07%

Winner

ALGN

0.00%

Free Cash Flow Yield

MDGL

-1.67%

Winner

ALGN

5.11%

P/S Ratio

MDGL

9.13

Winner

ALGN

3.11

P/B Ratio

MDGL

22.38

Winner

ALGN

2.96

MDGL vs ALGN - Historical Returns

Returns include dividend reinvestment.

Period	MDGL	ALGN
1 month	-5.46%	+1.60%
3 months	-5.99%	+12.94%
6 months	+9.22%	-2.92%
1 year	+36.67%	+26.90%
5 years(CAGR)	+42.99%	-23.47%
10 years(CAGR)	+51.21%	+6.57%
Max(CAGR)	+2.42%	+9.74%

MDGL

-5.46%

Winner

ALGN

+1.60%

MDGL

-5.99%

Winner

ALGN

+12.94%

Winner

MDGL

+9.22%

ALGN

-2.92%

Winner

MDGL

+36.67%

ALGN

+26.90%

5Y(CAGR)

Winner

MDGL

+42.99%

ALGN

-23.47%

10Y(CAGR)

Winner

MDGL

+51.21%

ALGN

+6.57%

Max(CAGR)

MDGL

+2.42%

Winner

ALGN

+9.74%

MDGL vs ALGN - Annual Returns (2001 - 2026)

Returns include dividend reinvestment.

Year	MDGL	ALGN
2026	-14.53%	+16.20%
2025	+85.59%	-25.10%
2024	+36.02%	-22.46%
2023	-18.93%	+29.07%
2022	+222.07%	-67.46%
2021	-22.80%	+24.83%
2020	+22.60%	+88.37%
2019	-18.06%	+38.06%
2018	+15.71%	-6.76%
2017	+475.13%	+129.16%
2016	+28.97%	+49.57%
2015	-87.74%	+17.17%
2014	-49.62%	-1.84%
2013	-45.64%	+101.20%
2012	+84.46%	+15.87%
2011	-24.56%	+19.40%
2010	+10.87%	+5.62%
2009	-17.99%	+100.45%
2008	-3.62%	-46.87%
2007	-26.29%	+24.94%
2006	N/A	+122.45%
2005	N/A	-38.73%
2004	N/A	-35.59%
2003	N/A	+502.77%
2002	N/A	-35.79%
2001	N/A	-73.34%

MDGL vs ALGN Drawdown Comparison

The maximum drawdown for MDGL was -98.40%, occurring on Feb 11, 2016. Recovery took 3162 trading sessions.

The maximum drawdown for ALGN was -92.30%, occurring on Nov 13, 2002. Recovery took 692 trading sessions.

The current MDGL drawdown is -15.80%. The current ALGN drawdown is -75.16%.

Rank	MDGL	ALGN
#1	-98.40% Jan 28, 2013 - Aug 22, 2025	-92.30% Jan 30, 2001 - Nov 3, 2003
#2	-87.64% Oct 5, 2007 - Jan 22, 2013	-82.89% Sep 8, 2021 - Sep 25, 2025
#3	-51.43% Jun 4, 2007 - Oct 4, 2007	-82.58% Oct 24, 2007 - Apr 24, 2012
#4	-29.36% Dec 22, 2025 - Mar 3, 2026	-75.18% Apr 19, 2004 - Apr 26, 2007
#5	-18.88% Feb 9, 2007 - Jun 4, 2007	-64.95% Sep 25, 2018 - Oct 22, 2020
#6	-10.10% Sep 30, 2025 - Nov 5, 2025	-35.18% Sep 13, 2012 - Jul 10, 2013
#7	-9.42% Nov 26, 2025 - Dec 22, 2025	-30.62% Jan 17, 2014 - Jun 16, 2015
#8	-8.01% Sep 8, 2025 - Sep 30, 2025	-22.28% Jan 26, 2018 - May 11, 2018
#9	-4.91% Nov 11, 2025 - Nov 17, 2025	-20.05% Feb 5, 2021 - Apr 27, 2021
#10	-4.32% Jan 23, 2013 - Jan 25, 2013	-18.56% Jul 25, 2007 - Oct 4, 2007
#11	-3.02% Nov 18, 2025 - Nov 24, 2025	-18.32% Jul 20, 2015 - Oct 23, 2015
#12	-1.52% Aug 29, 2025 - Sep 8, 2025	-17.71% Jan 26, 2004 - Apr 12, 2004
#13	-0.59% Aug 22, 2025 - Aug 26, 2025	-17.21% Nov 28, 2017 - Jan 17, 2018
#14	N/A	-14.67% Dec 1, 2003 - Jan 7, 2004
#15	N/A	-14.09% Oct 26, 2015 - Mar 2, 2016