LQDA vs SYRE

Comparison between Liquidia Corp (LQDA, Company) and Spyre Therapeutics Inc (SYRE, Company).

Both LQDA and SYRE are from the Healthcare sector.

5-Year PerformanceLQDA has outperformed SYRE, delivering a return of +95.6% compared to -13.2%

LQDA vs SYRE - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	LQDA(COMPANY)	SYRE(COMPANY)
Market Cap	$7B	$7.01B
Max Drawdown	93.87%	99.11%
Sharpe Ratio	3.14	2.77
5Y Beta	1.14	1.75
Industry	Drug Manufacturers - Specialty & Generic	Biotechnology
P/E Ratio	329.73	-36.02
Forward P/E	38.17	N/A
5Y EPS CAGR	N/A	-2.15%
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	0.59%	-2.65%
P/S Ratio	24.49	650.22
P/B Ratio	64.93	14.99

Market Cap

LQDA

$7B

Winner

SYRE

$7.01B

Max Drawdown

Winner

LQDA

93.87%

SYRE

99.11%

Sharpe Ratio

Winner

LQDA

3.14

SYRE

2.77

5Y Beta

Winner

LQDA

1.14

SYRE

1.75

Industry

LQDA

Drug Manufacturers - Specialty & Generic

SYRE

Biotechnology

P/E Ratio

LQDA

329.73

Winner

SYRE

-36.02

Forward P/E

LQDA

38.17

SYRE

N/A

5Y EPS CAGR

LQDA

N/A

SYRE

-2.15%

Debt to Equity

LQDA

0.00%

SYRE

0.00%

Free Cash Flow Yield

Winner

LQDA

0.59%

SYRE

-2.65%

P/S Ratio

Winner

LQDA

24.49

SYRE

650.22

P/B Ratio

LQDA

64.93

Winner

SYRE

14.99

LQDA vs SYRE - Historical Returns

Returns include dividend reinvestment.

Period	LQDA	SYRE
1 month	+43.22%	+25.26%
3 months	+109.47%	+82.07%
6 months	+151.37%	+183.29%
1 year	+554.48%	+458.90%
5 years(CAGR)	+95.57%	-13.19%
10 years(CAGR)	N/A	-3.31%
Max(CAGR)	+28.05%	-9.63%

Winner

LQDA

+43.22%

SYRE

+25.26%

Winner

LQDA

+109.47%

SYRE

+82.07%

LQDA

+151.37%

Winner

SYRE

+183.29%

Winner

LQDA

+554.48%

SYRE

+458.90%

5Y(CAGR)

Winner

LQDA

+95.57%

SYRE

-13.19%

10Y(CAGR)

LQDA

N/A

SYRE

-3.31%

Max(CAGR)

Winner

LQDA

+28.05%

SYRE

-9.63%

LQDA vs SYRE - Annual Returns (2016 - 2026)

Returns include dividend reinvestment.

Year	LQDA	SYRE
2026	+151.37%	+183.29%
2025	+185.04%	+37.36%
2024	+1.99%	+8.79%
2023	+97.54%	+104.27%
2022	+23.93%	-90.57%
2021	+62.33%	-44.51%
2020	-32.95%	+1.55%
2019	-78.84%	-4.98%
2018	+95.14%	+39.22%
2017	N/A	+18.38%
2016	N/A	-55.48%

LQDA vs SYRE Drawdown Comparison

The maximum drawdown for LQDA was -93.87%, occurring on Aug 4, 2021. Recovery took 1824 trading sessions.

The maximum drawdown for SYRE was -99.11%, occurring on Jun 21, 2023. This drawdown has not yet recovered.

The current LQDA drawdown is -1.00%. The current SYRE drawdown is -71.10%.

Rank	LQDA	SYRE
#1	-93.87% Oct 9, 2018 - Jan 13, 2026	-99.11% Apr 8, 2016 - Jun 21, 2023
#2	-35.66% Feb 3, 2026 - May 11, 2026	N/A
#3	-11.16% May 28, 2026 - Jun 4, 2026	N/A
#4	-8.70% Oct 3, 2018 - Oct 9, 2018	N/A
#5	-8.64% Aug 22, 2018 - Sep 4, 2018	N/A
#6	-8.03% Sep 27, 2018 - Oct 2, 2018	N/A
#7	-6.18% Sep 11, 2018 - Sep 21, 2018	N/A
#8	-5.60% Aug 14, 2018 - Aug 17, 2018	N/A
#9	-5.28% Jun 15, 2026 - Jun 22, 2026	N/A
#10	-5.15% Jan 14, 2026 - Jan 22, 2026	N/A
#11	-4.32% Sep 5, 2018 - Sep 10, 2018	N/A
#12	-4.00% May 14, 2026 - May 19, 2026	N/A
#13	-3.90% Jun 26, 2026 - Jun 30, 2026	N/A
#14	-3.03% May 21, 2026 - May 27, 2026	N/A
#15	-1.92% Jun 22, 2026 - Jun 24, 2026	N/A