LENZ vs KPTI

Comparison between LENZ Therapeutics Inc (LENZ, Company) and Karyopharm Therapeutics Inc (KPTI, Company).

Both LENZ and KPTI are from the Healthcare sector.

5-Year PerformanceLENZ has outperformed KPTI, delivering a return of -41.0% compared to -42.8%

LENZ vs KPTI - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	LENZ(COMPANY)	KPTI(COMPANY)
Market Cap	$206M	$205M
Max Drawdown	96.98%	99.50%
Sharpe Ratio	-1.47	1.24
5Y Beta	1.61	0.86
Industry	Biotechnology	Biotechnology
P/E Ratio	-1.84	-0.62
PEG Ratio	-0.02	-0.01
5Y EPS CAGR	N/A	-18.43%
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-42.38%	-28.78%
P/S Ratio	9.83	1.30
P/B Ratio	0.84	12.05

Market Cap

Winner

LENZ

$206M

KPTI

$205M

Max Drawdown

Winner

LENZ

96.98%

KPTI

99.50%

Sharpe Ratio

LENZ

-1.47

Winner

KPTI

1.24

5Y Beta

LENZ

1.61

Winner

KPTI

0.86

Industry

LENZ

Biotechnology

KPTI

Biotechnology

P/E Ratio

Winner

LENZ

-1.84

KPTI

-0.62

PEG Ratio

Winner

LENZ

-0.02

KPTI

-0.01

5Y EPS CAGR

LENZ

N/A

KPTI

-18.43%

Debt to Equity

LENZ

0.00%

KPTI

0.00%

Free Cash Flow Yield

LENZ

-42.38%

Winner

KPTI

-28.78%

P/S Ratio

LENZ

9.83

Winner

KPTI

1.30

P/B Ratio

Winner

LENZ

0.84

KPTI

12.05

LENZ vs KPTI - Historical Returns

Returns include dividend reinvestment.

Period	LENZ	KPTI
1 month	-14.41%	+6.56%
3 months	-42.72%	+20.25%
6 months	-62.68%	+36.69%
1 year	-77.11%	+117.89%
5 years(CAGR)	-41.02%	-42.76%
10 years(CAGR)	N/A	-22.75%
Max(CAGR)	-41.02%	-22.63%

LENZ

-14.41%

Winner

KPTI

+6.56%

LENZ

-42.72%

Winner

KPTI

+20.25%

LENZ

-62.68%

Winner

KPTI

+36.69%

LENZ

-77.11%

Winner

KPTI

+117.89%

5Y(CAGR)

Winner

LENZ

-41.02%

KPTI

-42.76%

10Y(CAGR)

LENZ

N/A

KPTI

-22.75%

Max(CAGR)

LENZ

-41.02%

Winner

KPTI

-22.63%

LENZ vs KPTI - Annual Returns (2013 - 2026)

Returns include dividend reinvestment.

Year	LENZ	KPTI
2026	-57.69%	+32.13%
2025	-43.44%	-39.54%
2024	+117.40%	-24.96%
2023	-18.38%	-73.47%
2022	-74.58%	-52.11%
2021	-32.81%	-62.00%
2020	N/A	-17.31%
2019	N/A	+100.52%
2018	N/A	-5.54%
2017	N/A	-0.41%
2016	N/A	-30.16%
2015	N/A	-65.12%
2014	N/A	+62.67%
2013	N/A	+42.80%

LENZ vs KPTI Drawdown Comparison

The maximum drawdown for LENZ was -95.80%, occurring on Jun 11, 2026. This drawdown has not yet recovered.

The maximum drawdown for KPTI was -99.50%, occurring on Apr 1, 2025. This drawdown has not yet recovered.

The current LENZ drawdown is -95.62%. The current KPTI drawdown is -98.66%.

Rank	LENZ	KPTI
#1	-95.80% Jun 30, 2021 - Jun 11, 2026	-99.50% Jun 13, 2014 - Apr 1, 2025
#2	N/A	-43.74% Mar 6, 2014 - Jun 13, 2014
#3	N/A	-10.42% Dec 20, 2013 - Jan 15, 2014
#4	N/A	-9.08% Jan 31, 2014 - Feb 12, 2014
#5	N/A	-8.83% Mar 4, 2014 - Mar 6, 2014
#6	N/A	-5.88% Jan 22, 2014 - Jan 30, 2014
#7	N/A	-4.87% Feb 27, 2014 - Mar 4, 2014
#8	N/A	-4.36% Feb 13, 2014 - Feb 20, 2014
#9	N/A	-3.39% Dec 9, 2013 - Dec 13, 2013
#10	N/A	-1.60% Nov 29, 2013 - Dec 6, 2013
#11	N/A	-1.48% Nov 8, 2013 - Nov 29, 2013
#12	N/A	-0.44% Nov 6, 2013 - Nov 8, 2013