KPTI vs QSI

Comparison between Karyopharm Therapeutics Inc (KPTI, Company) and Quantum-Si Incorporated - Class A (QSI, Company).

Both KPTI and QSI are from the Healthcare sector.

5-Year PerformanceQSI has outperformed KPTI, delivering a return of -37.3% compared to -42.8%

KPTI vs QSI - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	KPTI(COMPANY)	QSI(COMPANY)
Market Cap	$205M	$205M
Max Drawdown	99.50%	97.18%
Sharpe Ratio	1.17	-0.18
5Y Beta	0.85	2.33
Industry	Biotechnology	Medical Devices
P/E Ratio	-0.62	-1.78
PEG Ratio	-0.01	N/A
5Y EPS CAGR	-18.43%	N/A
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-28.78%	-46.72%
P/S Ratio	1.30	110.24
P/B Ratio	12.05	1.03

Market Cap

Winner

KPTI

$205M

QSI

$205M

Max Drawdown

KPTI

99.50%

Winner

QSI

97.18%

Sharpe Ratio

Winner

KPTI

1.17

QSI

-0.18

5Y Beta

Winner

KPTI

0.85

QSI

2.33

Industry

KPTI

Biotechnology

QSI

Medical Devices

P/E Ratio

KPTI

-0.62

Winner

QSI

-1.78

PEG Ratio

KPTI

-0.01

QSI

N/A

5Y EPS CAGR

KPTI

-18.43%

QSI

N/A

Debt to Equity

KPTI

0.00%

QSI

0.00%

Free Cash Flow Yield

Winner

KPTI

-28.78%

QSI

-46.72%

P/S Ratio

Winner

KPTI

1.30

QSI

110.24

P/B Ratio

KPTI

12.05

Winner

QSI

1.03

KPTI vs QSI - Historical Returns

Returns include dividend reinvestment.

Period	KPTI	QSI
1 month	+6.56%	+0.23%
3 months	+20.25%	-3.00%
6 months	+36.69%	-26.61%
1 year	+117.89%	-47.11%
5 years(CAGR)	-42.76%	-37.26%
10 years(CAGR)	-22.75%	N/A
Max(CAGR)	-22.63%	-34.33%

Winner

KPTI

+6.56%

QSI

+0.23%

Winner

KPTI

+20.25%

QSI

-3.00%

Winner

KPTI

+36.69%

QSI

-26.61%

Winner

KPTI

+117.89%

QSI

-47.11%

5Y(CAGR)

KPTI

-42.76%

Winner

QSI

-37.26%

10Y(CAGR)

KPTI

-22.75%

QSI

N/A

Max(CAGR)

Winner

KPTI

-22.63%

QSI

-34.33%

KPTI vs QSI - Annual Returns (2013 - 2026)

Returns include dividend reinvestment.

Year	KPTI	QSI
2026	+32.13%	-18.39%
2025	-39.54%	-74.18%
2024	-24.96%	+33.00%
2023	-73.47%	+9.24%
2022	-52.11%	-77.74%
2021	-62.00%	-24.98%
2020	-17.31%	+2.73%
2019	+100.52%	N/A
2018	-5.54%	N/A
2017	-0.41%	N/A
2016	-30.16%	N/A
2015	-65.12%	N/A
2014	+62.67%	N/A
2013	+42.80%	N/A

KPTI vs QSI Drawdown Comparison

The maximum drawdown for KPTI was -99.50%, occurring on Apr 1, 2025. This drawdown has not yet recovered.

The maximum drawdown for QSI was -97.18%, occurring on Nov 19, 2024. This drawdown has not yet recovered.

The current KPTI drawdown is -98.66%. The current QSI drawdown is -95.78%.

Rank	KPTI	QSI
#1	-99.50% Jun 13, 2014 - Apr 1, 2025	-97.18% Feb 18, 2021 - Nov 19, 2024
#2	-43.74% Mar 6, 2014 - Jun 13, 2014	-13.13% Dec 4, 2020 - Feb 18, 2021
#3	-10.42% Dec 20, 2013 - Jan 15, 2014	-0.00% Nov 20, 2020 - Nov 30, 2020
#4	-9.08% Jan 31, 2014 - Feb 12, 2014	N/A
#5	-8.83% Mar 4, 2014 - Mar 6, 2014	N/A
#6	-5.88% Jan 22, 2014 - Jan 30, 2014	N/A
#7	-4.87% Feb 27, 2014 - Mar 4, 2014	N/A
#8	-4.36% Feb 13, 2014 - Feb 20, 2014	N/A
#9	-3.39% Dec 9, 2013 - Dec 13, 2013	N/A
#10	-1.60% Nov 29, 2013 - Dec 6, 2013	N/A
#11	-1.48% Nov 8, 2013 - Nov 29, 2013	N/A
#12	-0.44% Nov 6, 2013 - Nov 8, 2013	N/A