KPTI vs AP

Comparison between Karyopharm Therapeutics Inc (KPTI, Company) and Ampco-Pittsburgh Corp (AP, Company).

KPTI is from the Healthcare sector, while AP is from the Industrials sector.

5-Year PerformanceAP has outperformed KPTI, delivering a return of +12.9% compared to -42.3%

KPTI vs AP - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	KPTI(COMPANY)	AP(COMPANY)
Market Cap	$205M	$205M
Max Drawdown	99.50%	98.60%
Sharpe Ratio	1.24	1.94
5Y Beta	0.86	1.64
Industry	Biotechnology	Metal Fabrication
P/E Ratio	-0.62	-3.01
Forward P/E	N/A	29.41
PEG Ratio	-0.01	1.12
5Y Dividends CAGR	N/A	-8.97%
5Y EPS CAGR	-18.43%	N/A
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-28.78%	-1.13%
P/S Ratio	1.30	0.48
P/B Ratio	12.05	6.33

Market Cap

Winner

KPTI

$205M

Max Drawdown

KPTI

99.50%

Winner

98.60%

Sharpe Ratio

KPTI

1.24

Winner

1.94

5Y Beta

Winner

KPTI

0.86

1.64

Industry

KPTI

Biotechnology

Metal Fabrication

P/E Ratio

KPTI

-0.62

Winner

-3.01

Forward P/E

KPTI

N/A

29.41

PEG Ratio

Winner

KPTI

-0.01

1.12

5Y Dividends CAGR

KPTI

N/A

-8.97%

5Y EPS CAGR

KPTI

-18.43%

N/A

Debt to Equity

KPTI

0.00%

Free Cash Flow Yield

KPTI

-28.78%

Winner

-1.13%

P/S Ratio

KPTI

1.30

Winner

0.48

P/B Ratio

KPTI

12.05

Winner

6.33

KPTI vs AP - Historical Returns

Returns include dividend reinvestment.

Period	KPTI	AP
1 month	+25.68%	+9.59%
3 months	+12.75%	+42.40%
6 months	+43.67%	+223.98%
1 year	+112.33%	+269.25%
5 years(CAGR)	-42.26%	+12.94%
10 years(CAGR)	-22.20%	-0.75%
Max(CAGR)	-22.53%	+2.25%

Winner

KPTI

+25.68%

+9.59%

KPTI

+12.75%

Winner

+42.40%

KPTI

+43.67%

Winner

+223.98%

KPTI

+112.33%

Winner

+269.25%

5Y(CAGR)

KPTI

-42.26%

Winner

+12.94%

10Y(CAGR)

KPTI

-22.20%

Winner

-0.75%

Max(CAGR)

KPTI

-22.53%

Winner

+2.25%

KPTI vs AP - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	KPTI	AP
2026	+34.08%	+139.24%
2025	-39.54%	+139.01%
2024	-24.96%	-25.09%
2023	-73.47%	+3.41%
2022	-52.11%	-50.78%
2021	-62.00%	-11.50%
2020	-17.31%	+78.50%
2019	+100.52%	-25.86%
2018	-5.54%	-75.97%
2017	-0.41%	-22.35%
2016	-30.16%	+70.98%
2015	-65.12%	-44.06%
2014	+62.67%	+3.04%
2013	+42.80%	-3.14%
2012	N/A	+6.67%
2011	N/A	-29.51%
2010	N/A	-10.77%
2009	N/A	+38.49%
2008	N/A	-40.27%
2007	N/A	+21.91%
2006	N/A	+144.25%
2005	N/A	+2.03%
2004	N/A	+11.64%
2003	N/A	+14.22%
2002	N/A	+16.75%
2001	N/A	-8.52%
2000	N/A	+22.91%
1999	N/A	-11.91%

KPTI vs AP Drawdown Comparison

The maximum drawdown for KPTI was -99.50%, occurring on Apr 1, 2025. This drawdown has not yet recovered.

The maximum drawdown for AP was -98.06%, occurring on Jul 2, 2024. This drawdown has not yet recovered.

The current KPTI drawdown is -98.64%. The current AP drawdown is -69.26%.

Rank	KPTI	AP
#1	-99.50% Jun 13, 2014 - Apr 1, 2025	-98.06% Jul 19, 2007 - Jul 2, 2024
#2	-43.74% Mar 6, 2014 - Jun 13, 2014	-36.08% Dec 4, 2006 - Apr 23, 2007
#3	-10.42% Dec 20, 2013 - Jan 15, 2014	-31.48% Jun 13, 2003 - Dec 30, 2004
#4	-9.08% Jan 31, 2014 - Feb 12, 2014	-30.72% Jan 25, 2001 - Nov 27, 2002
#5	-8.83% Mar 4, 2014 - Mar 6, 2014	-28.98% Jun 2, 2006 - Oct 26, 2006
#6	-5.88% Jan 22, 2014 - Jan 30, 2014	-25.67% Nov 18, 1999 - Jan 5, 2001
#7	-4.87% Feb 27, 2014 - Mar 4, 2014	-23.91% Dec 30, 2004 - Aug 9, 2005
#8	-4.36% Feb 13, 2014 - Feb 20, 2014	-13.86% Feb 6, 2006 - Apr 3, 2006
#9	-3.39% Dec 9, 2013 - Dec 13, 2013	-13.78% May 4, 2006 - May 18, 2006
#10	-1.60% Nov 29, 2013 - Dec 6, 2013	-11.81% Sep 27, 2005 - Jan 27, 2006
#11	-1.48% Nov 8, 2013 - Nov 29, 2013	-10.04% Oct 26, 2006 - Nov 8, 2006
#12	-0.44% Nov 6, 2013 - Nov 8, 2013	-9.50% Jan 15, 2003 - Mar 25, 2003
#13	N/A	-8.98% Apr 10, 2006 - Apr 19, 2006
#14	N/A	-6.87% Nov 15, 2006 - Dec 4, 2006
#15	N/A	-6.78% May 29, 2007 - Jun 29, 2007