KPTI vs LENZ

Comparison between Karyopharm Therapeutics Inc (KPTI, Company) and LENZ Therapeutics Inc (LENZ, Company).

Both KPTI and LENZ are from the Healthcare sector.

5-Year PerformanceLENZ has outperformed KPTI, delivering a return of -41.2% compared to -42.3%

KPTI vs LENZ - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	KPTI(COMPANY)	LENZ(COMPANY)
Market Cap	$205M	$206M
Max Drawdown	99.50%	96.98%
Sharpe Ratio	1.24	-1.47
5Y Beta	0.86	1.61
Industry	Biotechnology	Biotechnology
P/E Ratio	-0.62	-1.84
PEG Ratio	-0.01	-0.02
5Y EPS CAGR	-18.43%	N/A
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-28.78%	-42.38%
P/S Ratio	1.30	9.83
P/B Ratio	12.05	0.84

Market Cap

KPTI

$205M

Winner

LENZ

$206M

Max Drawdown

KPTI

99.50%

Winner

LENZ

96.98%

Sharpe Ratio

Winner

KPTI

1.24

LENZ

-1.47

5Y Beta

Winner

KPTI

0.86

LENZ

1.61

Industry

KPTI

Biotechnology

LENZ

Biotechnology

P/E Ratio

KPTI

-0.62

Winner

LENZ

-1.84

PEG Ratio

KPTI

-0.01

Winner

LENZ

-0.02

5Y EPS CAGR

KPTI

-18.43%

LENZ

N/A

Debt to Equity

KPTI

0.00%

LENZ

0.00%

Free Cash Flow Yield

Winner

KPTI

-28.78%

LENZ

-42.38%

P/S Ratio

Winner

KPTI

1.30

LENZ

9.83

P/B Ratio

KPTI

12.05

Winner

LENZ

0.84

KPTI vs LENZ - Historical Returns

Returns include dividend reinvestment.

Period	KPTI	LENZ
1 month	+25.68%	-9.67%
3 months	+12.75%	-43.53%
6 months	+43.67%	-61.18%
1 year	+112.33%	-77.00%
5 years(CAGR)	-42.26%	-41.22%
10 years(CAGR)	-22.20%	N/A
Max(CAGR)	-22.53%	-41.22%

Winner

KPTI

+25.68%

LENZ

-9.67%

Winner

KPTI

+12.75%

LENZ

-43.53%

Winner

KPTI

+43.67%

LENZ

-61.18%

Winner

KPTI

+112.33%

LENZ

-77.00%

5Y(CAGR)

KPTI

-42.26%

Winner

LENZ

-41.22%

10Y(CAGR)

KPTI

-22.20%

LENZ

N/A

Max(CAGR)

Winner

KPTI

-22.53%

LENZ

-41.22%

KPTI vs LENZ - Annual Returns (2013 - 2026)

Returns include dividend reinvestment.

Year	KPTI	LENZ
2026	+34.08%	-58.56%
2025	-39.54%	-43.44%
2024	-24.96%	+117.40%
2023	-73.47%	-18.38%
2022	-52.11%	-74.58%
2021	-62.00%	-32.81%
2020	-17.31%	N/A
2019	+100.52%	N/A
2018	-5.54%	N/A
2017	-0.41%	N/A
2016	-30.16%	N/A
2015	-65.12%	N/A
2014	+62.67%	N/A
2013	+42.80%	N/A

KPTI vs LENZ Drawdown Comparison

The maximum drawdown for KPTI was -99.50%, occurring on Apr 1, 2025. This drawdown has not yet recovered.

The maximum drawdown for LENZ was -95.80%, occurring on Jun 11, 2026. This drawdown has not yet recovered.

The current KPTI drawdown is -98.64%. The current LENZ drawdown is -95.71%.

Rank	KPTI	LENZ
#1	-99.50% Jun 13, 2014 - Apr 1, 2025	-95.80% Jun 30, 2021 - Jun 11, 2026
#2	-43.74% Mar 6, 2014 - Jun 13, 2014	N/A
#3	-10.42% Dec 20, 2013 - Jan 15, 2014	N/A
#4	-9.08% Jan 31, 2014 - Feb 12, 2014	N/A
#5	-8.83% Mar 4, 2014 - Mar 6, 2014	N/A
#6	-5.88% Jan 22, 2014 - Jan 30, 2014	N/A
#7	-4.87% Feb 27, 2014 - Mar 4, 2014	N/A
#8	-4.36% Feb 13, 2014 - Feb 20, 2014	N/A
#9	-3.39% Dec 9, 2013 - Dec 13, 2013	N/A
#10	-1.60% Nov 29, 2013 - Dec 6, 2013	N/A
#11	-1.48% Nov 8, 2013 - Nov 29, 2013	N/A
#12	-0.44% Nov 6, 2013 - Nov 8, 2013	N/A