KPTI vs TVAI

Comparison between Karyopharm Therapeutics Inc (KPTI, Company) and Thayer Ventures Acquisition Corporation II (TVAI, Company).

KPTI is from the Healthcare sector, while TVAI is from the Financial Services sector.

KPTI vs TVAI - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	KPTI(COMPANY)	TVAI(COMPANY)
Market Cap	$205M	$207M
Max Drawdown	99.50%	0.88%
Sharpe Ratio	1.24	0.02
5Y Beta	0.86	-0.00
Industry	Biotechnology	Shell Companies
P/E Ratio	-0.62	35.24
PEG Ratio	-0.01	N/A
5Y EPS CAGR	-18.43%	N/A
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-28.78%	0.23%
P/S Ratio	1.30	N/A
P/B Ratio	12.05	1.41

Market Cap

KPTI

$205M

Winner

TVAI

$207M

Max Drawdown

KPTI

99.50%

Winner

TVAI

0.88%

Sharpe Ratio

Winner

KPTI

1.24

TVAI

0.02

5Y Beta

KPTI

0.86

Winner

TVAI

-0.00

Industry

KPTI

Biotechnology

TVAI

Shell Companies

P/E Ratio

Winner

KPTI

-0.62

TVAI

35.24

PEG Ratio

KPTI

-0.01

TVAI

N/A

5Y EPS CAGR

KPTI

-18.43%

TVAI

N/A

Debt to Equity

Winner

KPTI

0.00%

TVAI

0.00%

Free Cash Flow Yield

KPTI

-28.78%

Winner

TVAI

0.23%

P/S Ratio

KPTI

1.30

TVAI

N/A

P/B Ratio

KPTI

12.05

Winner

TVAI

1.41

KPTI vs TVAI - Historical Returns

Returns include dividend reinvestment.

Period	KPTI	TVAI
1 month	+6.56%	+0.29%
3 months	+20.25%	+1.08%
6 months	+36.69%	+1.75%
1 year	+117.89%	+3.36%
5 years(CAGR)	-42.76%	N/A
10 years(CAGR)	-22.75%	N/A
Max(CAGR)	-22.63%	+3.56%

Winner

KPTI

+6.56%

TVAI

+0.29%

Winner

KPTI

+20.25%

TVAI

+1.08%

Winner

KPTI

+36.69%

TVAI

+1.75%

Winner

KPTI

+117.89%

TVAI

+3.36%

5Y(CAGR)

KPTI

-42.76%

TVAI

N/A

10Y(CAGR)

KPTI

-22.75%

TVAI

N/A

Max(CAGR)

KPTI

-22.63%

Winner

TVAI

+3.56%

KPTI vs TVAI - Annual Returns (2013 - 2026)

Returns include dividend reinvestment.

Year	KPTI	TVAI
2026	+32.13%	+1.78%
2025	-39.54%	+1.56%
2024	-24.96%	N/A
2023	-73.47%	N/A
2022	-52.11%	N/A
2021	-62.00%	N/A
2020	-17.31%	N/A
2019	+100.52%	N/A
2018	-5.54%	N/A
2017	-0.41%	N/A
2016	-30.16%	N/A
2015	-65.12%	N/A
2014	+62.67%	N/A
2013	+42.80%	N/A

KPTI vs TVAI Drawdown Comparison

The maximum drawdown for KPTI was -99.50%, occurring on Apr 1, 2025. This drawdown has not yet recovered.

The maximum drawdown for TVAI was -0.88%, occurring on Jan 28, 2026. Recovery took 65 trading sessions.

The current KPTI drawdown is -98.66%. The current TVAI drawdown is -0.19%.

Rank	KPTI	TVAI
#1	-99.50% Jun 13, 2014 - Apr 1, 2025	-0.88% Jan 26, 2026 - Apr 29, 2026
#2	-43.74% Mar 6, 2014 - Jun 13, 2014	-0.50% Sep 22, 2025 - Nov 13, 2025
#3	-10.42% Dec 20, 2013 - Jan 15, 2014	-0.30% Aug 15, 2025 - Sep 22, 2025
#4	-9.08% Jan 31, 2014 - Feb 12, 2014	-0.29% Jan 20, 2026 - Jan 22, 2026
#5	-8.83% Mar 4, 2014 - Mar 6, 2014	-0.19% Jun 11, 2026 - Jun 12, 2026
#6	-5.88% Jan 22, 2014 - Jan 30, 2014	-0.17% Dec 18, 2025 - Jan 15, 2026
#7	-4.87% Feb 27, 2014 - Mar 4, 2014	-0.15% Dec 4, 2025 - Dec 18, 2025
#8	-4.36% Feb 13, 2014 - Feb 20, 2014	-0.10% Jul 11, 2025 - Aug 12, 2025
#9	-3.39% Dec 9, 2013 - Dec 13, 2013	-0.10% Jan 22, 2026 - Jan 26, 2026
#10	-1.60% Nov 29, 2013 - Dec 6, 2013	-0.10% May 29, 2026 - Jun 11, 2026
#11	-1.48% Nov 8, 2013 - Nov 29, 2013	N/A
#12	-0.44% Nov 6, 2013 - Nov 8, 2013	N/A