KRYS vs PTGX

Comparison between Krystal Biotech Inc (KRYS, Company) and Protagonist Therapeutics Inc (PTGX, Company).

Both KRYS and PTGX are from the Healthcare sector.

5-Year PerformanceKRYS has outperformed PTGX, delivering a return of +43.6% compared to +27.5%

KRYS vs PTGX - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	KRYS(COMPANY)	PTGX(COMPANY)
Market Cap	$9.85B	$9.83B
Max Drawdown	53.42%	85.79%
Sharpe Ratio	2.14	2.17
5Y Beta	0.85	N/A
Industry	Biotechnology	Biotechnology
P/E Ratio	40.35	122.81
Forward P/E	43.67	38.76
PEG Ratio	0.65	2.71
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	2.62%	1.33%
P/S Ratio	22.33	35.59
P/B Ratio	7.15	11.53

Market Cap

Winner

KRYS

$9.85B

PTGX

$9.83B

Max Drawdown

Winner

KRYS

53.42%

PTGX

85.79%

Sharpe Ratio

KRYS

2.14

Winner

PTGX

2.17

5Y Beta

KRYS

0.85

PTGX

N/A

Industry

KRYS

Biotechnology

PTGX

Biotechnology

P/E Ratio

Winner

KRYS

40.35

PTGX

122.81

Forward P/E

KRYS

43.67

Winner

PTGX

38.76

PEG Ratio

Winner

KRYS

0.65

PTGX

2.71

Debt to Equity

KRYS

0.00%

PTGX

0.00%

Free Cash Flow Yield

Winner

KRYS

2.62%

PTGX

1.33%

P/S Ratio

Winner

KRYS

22.33

PTGX

35.59

P/B Ratio

Winner

KRYS

7.15

PTGX

11.53

KRYS vs PTGX - Historical Returns

Returns include dividend reinvestment.

Period	KRYS	PTGX
1 month	-6.21%	+11.66%
3 months	+14.08%	+56.18%
6 months	+17.48%	+89.59%
1 year	+127.49%	+179.91%
5 years(CAGR)	+43.57%	+27.52%
10 years(CAGR)	+47.18%	+29.74%
Max(CAGR)	+47.18%	+29.62%

KRYS

-6.21%

Winner

PTGX

+11.66%

KRYS

+14.08%

Winner

PTGX

+56.18%

KRYS

+17.48%

Winner

PTGX

+89.59%

KRYS

+127.49%

Winner

PTGX

+179.91%

5Y(CAGR)

Winner

KRYS

+43.57%

PTGX

+27.52%

10Y(CAGR)

Winner

KRYS

+47.18%

PTGX

+29.74%

Max(CAGR)

Winner

KRYS

+47.18%

PTGX

+29.62%

KRYS vs PTGX - Annual Returns (2016 - 2026)

Returns include dividend reinvestment.

Year	KRYS	PTGX
2026	+34.79%	+80.48%
2025	+57.53%	+124.06%
2024	+25.37%	+64.82%
2023	+56.58%	+112.71%
2022	+9.86%	-69.11%
2021	+17.72%	+74.49%
2020	+5.28%	+190.91%
2019	+142.47%	+2.32%
2018	+126.36%	-68.18%
2017	-1.13%	-1.79%
2016	N/A	+87.95%

KRYS vs PTGX Drawdown Comparison

The maximum drawdown for KRYS was -53.42%, occurring on Nov 26, 2021. Recovery took 190 trading sessions.

The maximum drawdown for PTGX was -85.79%, occurring on Jun 13, 2022. Recovery took 882 trading sessions.

The current KRYS drawdown is -11.99%. The current PTGX drawdown is -0.81%.

Rank	KRYS	PTGX
#1	-53.42% Mar 1, 2021 - Nov 29, 2021	-85.79% Sep 1, 2021 - Mar 10, 2025
#2	-46.65% Feb 12, 2020 - Jan 8, 2021	-82.13% Dec 5, 2016 - Feb 16, 2021
#3	-44.55% Nov 29, 2021 - Apr 13, 2023	-31.58% Mar 11, 2025 - Aug 27, 2025
#4	-42.26% Jul 26, 2024 - Nov 24, 2025	-20.33% Oct 17, 2016 - Nov 10, 2016
#5	-35.34% Jul 22, 2019 - Nov 13, 2019	-19.04% Mar 19, 2021 - May 18, 2021
#6	-28.43% Sep 11, 2018 - Oct 16, 2018	-16.38% Dec 12, 2025 - Mar 9, 2026
#7	-27.86% Dec 13, 2019 - Feb 12, 2020	-15.52% Oct 10, 2025 - Nov 24, 2025
#8	-26.81% Oct 18, 2017 - Mar 16, 2018	-12.77% Feb 16, 2021 - Mar 2, 2021
#9	-26.58% Jan 8, 2019 - Mar 25, 2019	-12.03% Apr 17, 2026 - Jun 11, 2026
#10	-26.34% Jun 13, 2023 - Jan 22, 2024	-11.53% Aug 19, 2016 - Aug 31, 2016
#11	-24.99% May 14, 2019 - Jun 24, 2019	-9.62% Jun 8, 2021 - Jun 11, 2021
#12	-24.14% Oct 16, 2018 - Nov 30, 2018	-8.53% Aug 27, 2025 - Sep 18, 2025
#13	-23.42% Mar 16, 2018 - Jun 6, 2018	-7.78% Jul 7, 2026 - Jul 17, 2026
#14	-19.86% Nov 30, 2018 - Jan 7, 2019	-7.43% Mar 31, 2026 - Apr 15, 2026
#15	-17.56% Jan 22, 2024 - Feb 26, 2024	-7.20% Jun 14, 2021 - Jun 16, 2021