KPTI vs RANI

Comparison between Karyopharm Therapeutics Inc (KPTI, Company) and Rani Therapeutics Holdings Inc Class A (RANI, Company).

Both KPTI and RANI are from the Healthcare sector.

5-Year PerformanceRANI has outperformed KPTI, delivering a return of -39.6% compared to -44.3%

KPTI vs RANI - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	KPTI(COMPANY)	RANI(COMPANY)
Market Cap	$162M	$161M
Max Drawdown	99.50%	98.83%
Sharpe Ratio	1.05	0.92
5Y Beta	0.83	2.21
Industry	Biotechnology	Biotechnology
P/E Ratio	-0.49	-1.61
PEG Ratio	-0.00	N/A
5Y EPS CAGR	-18.43%	N/A
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-36.52%	-10.60%
P/S Ratio	1.08	38.90
P/B Ratio	12.05	2.76

Market Cap

Winner

KPTI

$162M

RANI

$161M

Max Drawdown

KPTI

99.50%

Winner

RANI

98.83%

Sharpe Ratio

Winner

KPTI

1.05

RANI

0.92

5Y Beta

Winner

KPTI

0.83

RANI

2.21

Industry

KPTI

Biotechnology

RANI

Biotechnology

P/E Ratio

KPTI

-0.49

Winner

RANI

-1.61

PEG Ratio

KPTI

-0.00

RANI

N/A

5Y EPS CAGR

KPTI

-18.43%

RANI

N/A

Debt to Equity

KPTI

0.00%

RANI

0.00%

Free Cash Flow Yield

KPTI

-36.52%

Winner

RANI

-10.60%

P/S Ratio

Winner

KPTI

1.08

RANI

38.90

P/B Ratio

KPTI

12.05

Winner

RANI

2.76

KPTI vs RANI - Historical Returns

Returns include dividend reinvestment.

Period	KPTI	RANI
1 month	-26.53%	+17.88%
3 months	-18.97%	-2.79%
6 months	+7.59%	-35.97%
1 year	+45.88%	+95.60%
5 years(CAGR)	-44.33%	-39.64%
10 years(CAGR)	-23.66%	N/A
Max(CAGR)	-24.22%	-39.64%

KPTI

-26.53%

Winner

RANI

+17.88%

KPTI

-18.97%

Winner

RANI

-2.79%

Winner

KPTI

+7.59%

RANI

-35.97%

KPTI

+45.88%

Winner

RANI

+95.60%

5Y(CAGR)

KPTI

-44.33%

Winner

RANI

-39.64%

10Y(CAGR)

KPTI

-23.66%

RANI

N/A

Max(CAGR)

Winner

KPTI

-24.22%

RANI

-39.64%

KPTI vs RANI - Annual Returns (2013 - 2026)

Returns include dividend reinvestment.

Year	KPTI	RANI
2026	-1.39%	-34.56%
2025	-39.54%	-7.53%
2024	-24.96%	-59.35%
2023	-73.47%	-43.73%
2022	-52.11%	-65.29%
2021	-62.00%	+48.64%
2020	-17.31%	N/A
2019	+100.52%	N/A
2018	-5.54%	N/A
2017	-0.41%	N/A
2016	-30.16%	N/A
2015	-65.12%	N/A
2014	+62.67%	N/A
2013	+42.80%	N/A

KPTI vs RANI Drawdown Comparison

The maximum drawdown for KPTI was -99.50%, occurring on Apr 1, 2025. This drawdown has not yet recovered.

The maximum drawdown for RANI was -98.83%, occurring on Jul 16, 2025. This drawdown has not yet recovered.

The current KPTI drawdown is -99.00%. The current RANI drawdown is -97.46%.

Rank	KPTI	RANI
#1	-99.50% Jun 13, 2014 - Apr 1, 2025	-98.83% Nov 18, 2021 - Jul 16, 2025
#2	-43.74% Mar 6, 2014 - Jun 13, 2014	-25.36% Aug 11, 2021 - Sep 13, 2021
#3	-10.42% Dec 20, 2013 - Jan 15, 2014	-24.92% Sep 13, 2021 - Oct 27, 2021
#4	-9.08% Jan 31, 2014 - Feb 12, 2014	-17.37% Nov 4, 2021 - Nov 17, 2021
#5	-8.83% Mar 4, 2014 - Mar 6, 2014	-9.95% Oct 28, 2021 - Nov 2, 2021
#6	-5.88% Jan 22, 2014 - Jan 30, 2014	-2.73% Jul 30, 2021 - Aug 4, 2021
#7	-4.87% Feb 27, 2014 - Mar 4, 2014	-0.25% Aug 4, 2021 - Aug 9, 2021
#8	-4.36% Feb 13, 2014 - Feb 20, 2014	N/A
#9	-3.39% Dec 9, 2013 - Dec 13, 2013	N/A
#10	-1.60% Nov 29, 2013 - Dec 6, 2013	N/A
#11	-1.48% Nov 8, 2013 - Nov 29, 2013	N/A
#12	-0.44% Nov 6, 2013 - Nov 8, 2013	N/A