KPTI vs IPHA

Comparison between Karyopharm Therapeutics Inc (KPTI, Company) and Innate Pharma (IPHA, Company).

Both KPTI and IPHA are from the Healthcare sector.

5-Year PerformanceIPHA has outperformed KPTI, delivering a return of -11.8% compared to -44.3%

KPTI vs IPHA - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	KPTI(COMPANY)	IPHA(COMPANY)
Market Cap	$162M	$162M
Max Drawdown	99.50%	85.73%
Sharpe Ratio	1.05	0.27
5Y Beta	0.83	0.62
Industry	Biotechnology	Biotechnology
P/E Ratio	-0.49	-1.34
PEG Ratio	-0.00	-0.01
5Y EPS CAGR	-18.43%	1.02%
Debt to Equity	0.00%	-104.00%
Free Cash Flow Yield	-36.52%	-65.18%
P/S Ratio	1.08	18.51
P/B Ratio	12.05	20.10

Market Cap

KPTI

$162M

Winner

IPHA

$162M

Max Drawdown

KPTI

99.50%

Winner

IPHA

85.73%

Sharpe Ratio

Winner

KPTI

1.05

IPHA

0.27

5Y Beta

KPTI

0.83

Winner

IPHA

0.62

Industry

KPTI

Biotechnology

IPHA

Biotechnology

P/E Ratio

KPTI

-0.49

Winner

IPHA

-1.34

PEG Ratio

KPTI

-0.00

Winner

IPHA

-0.01

5Y EPS CAGR

KPTI

-18.43%

Winner

IPHA

1.02%

Debt to Equity

KPTI

0.00%

Winner

IPHA

-104.00%

Free Cash Flow Yield

Winner

KPTI

-36.52%

IPHA

-65.18%

P/S Ratio

Winner

KPTI

1.08

IPHA

18.51

P/B Ratio

Winner

KPTI

12.05

IPHA

20.10

KPTI vs IPHA - Historical Returns

Returns include dividend reinvestment.

Period	KPTI	IPHA
1 month	-26.53%	-6.88%
3 months	-18.97%	+28.47%
6 months	+7.59%	-1.68%
1 year	+45.88%	-11.07%
5 years(CAGR)	-44.33%	-11.81%
10 years(CAGR)	-23.66%	N/A
Max(CAGR)	-24.22%	-16.68%

KPTI

-26.53%

Winner

IPHA

-6.88%

KPTI

-18.97%

Winner

IPHA

+28.47%

Winner

KPTI

+7.59%

IPHA

-1.68%

Winner

KPTI

+45.88%

IPHA

-11.07%

5Y(CAGR)

KPTI

-44.33%

Winner

IPHA

-11.81%

10Y(CAGR)

KPTI

-23.66%

IPHA

N/A

Max(CAGR)

KPTI

-24.22%

Winner

IPHA

-16.68%

KPTI vs IPHA - Annual Returns (2013 - 2026)

Returns include dividend reinvestment.

Year	KPTI	IPHA
2026	-1.39%	-3.30%
2025	-39.54%	-6.42%
2024	-24.96%	-32.35%
2023	-73.47%	-17.65%
2022	-52.11%	-22.29%
2021	-62.00%	+5.80%
2020	-17.31%	-43.97%
2019	+100.52%	+6.45%
2018	-5.54%	N/A
2017	-0.41%	N/A
2016	-30.16%	N/A
2015	-65.12%	N/A
2014	+62.67%	N/A
2013	+42.80%	N/A

KPTI vs IPHA Drawdown Comparison

The maximum drawdown for KPTI was -99.50%, occurring on Apr 1, 2025. This drawdown has not yet recovered.

The maximum drawdown for IPHA was -85.73%, occurring on Mar 20, 2026. This drawdown has not yet recovered.

The current KPTI drawdown is -99.00%. The current IPHA drawdown is -78.54%.

Rank	KPTI	IPHA
#1	-99.50% Jun 13, 2014 - Apr 1, 2025	-85.73% May 11, 2020 - Mar 20, 2026
#2	-43.74% Mar 6, 2014 - Jun 13, 2014	-52.20% Feb 19, 2020 - May 11, 2020
#3	-10.42% Dec 20, 2013 - Jan 15, 2014	-12.06% Nov 11, 2019 - Jan 2, 2020
#4	-9.08% Jan 31, 2014 - Feb 12, 2014	-10.16% Jan 23, 2020 - Feb 13, 2020
#5	-8.83% Mar 4, 2014 - Mar 6, 2014	-9.99% Jan 8, 2020 - Jan 23, 2020
#6	-5.88% Jan 22, 2014 - Jan 30, 2014	-8.86% Oct 21, 2019 - Nov 5, 2019
#7	-4.87% Feb 27, 2014 - Mar 4, 2014	-4.27% Feb 13, 2020 - Feb 18, 2020
#8	-4.36% Feb 13, 2014 - Feb 20, 2014	-3.22% Nov 7, 2019 - Nov 11, 2019
#9	-3.39% Dec 9, 2013 - Dec 13, 2013	-1.78% Jan 2, 2020 - Jan 6, 2020
#10	-1.60% Nov 29, 2013 - Dec 6, 2013	N/A
#11	-1.48% Nov 8, 2013 - Nov 29, 2013	N/A
#12	-0.44% Nov 6, 2013 - Nov 8, 2013	N/A