IONS vs RMBS

Comparison between Ionis Pharmaceuticals Inc (IONS, Company) and Rambus Inc (RMBS, Company).

IONS is from the Healthcare sector, while RMBS is from the Technology sector.

5-Year PerformanceRMBS has outperformed IONS, delivering a return of +30.5% compared to +7.5%

IONS vs RMBS - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	IONS(COMPANY)	RMBS(COMPANY)
Market Cap	$8.95B	$8.95B
Max Drawdown	91.72%	97.16%
Sharpe Ratio	0.66	0.61
5Y Beta	0.66	2.54
Industry	Biotechnology	Semiconductors
P/E Ratio	-21.43	38.81
Forward P/E	90.91	24.15
PEG Ratio	25.70	3.78
5Y EPS CAGR	-8.41%	N/A
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-6.27%	3.74%
P/S Ratio	8.64	11.88
P/B Ratio	18.82	6.47

Market Cap

IONS

$8.95B

Winner

RMBS

$8.95B

Max Drawdown

Winner

IONS

91.72%

RMBS

97.16%

Sharpe Ratio

Winner

IONS

0.66

RMBS

0.61

5Y Beta

Winner

IONS

0.66

RMBS

2.54

Industry

IONS

Biotechnology

RMBS

Semiconductors

P/E Ratio

Winner

IONS

-21.43

RMBS

38.81

Forward P/E

IONS

90.91

Winner

RMBS

24.15

PEG Ratio

IONS

25.70

Winner

RMBS

3.78

5Y EPS CAGR

IONS

-8.41%

RMBS

N/A

Debt to Equity

IONS

0.00%

RMBS

0.00%

Free Cash Flow Yield

IONS

-6.27%

Winner

RMBS

3.74%

P/S Ratio

Winner

IONS

8.64

RMBS

11.88

P/B Ratio

IONS

18.82

Winner

RMBS

6.47

IONS vs RMBS - Historical Returns

Returns include dividend reinvestment.

Period	IONS	RMBS
1 month	-32.80%	-32.51%
3 months	-28.73%	-22.18%
6 months	-35.55%	-21.30%
1 year	+22.85%	+19.30%
5 years(CAGR)	+7.49%	+30.51%
10 years(CAGR)	+6.20%	+20.81%
Max(CAGR)	+6.16%	+6.51%

IONS

-32.80%

Winner

RMBS

-32.51%

IONS

-28.73%

Winner

RMBS

-22.18%

IONS

-35.55%

Winner

RMBS

-21.30%

Winner

IONS

+22.85%

RMBS

+19.30%

5Y(CAGR)

IONS

+7.49%

Winner

RMBS

+30.51%

10Y(CAGR)

IONS

+6.20%

Winner

RMBS

+20.81%

Max(CAGR)

IONS

+6.16%

Winner

RMBS

+6.51%

IONS vs RMBS - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	IONS	RMBS
2026	-33.12%	-9.77%
2025	+128.05%	+71.76%
2024	-33.88%	-18.99%
2023	+34.62%	+94.89%
2022	+15.86%	+22.17%
2021	-46.41%	+67.94%
2020	-7.14%	+25.34%
2019	+12.35%	+71.97%
2018	+9.77%	-46.33%
2017	+6.25%	+0.42%
2016	-22.45%	+18.81%
2015	+0.58%	+1.13%
2014	+54.85%	+16.00%
2013	+268.21%	+80.73%
2012	+44.00%	-39.95%
2011	-29.93%	-63.17%
2010	-10.20%	-11.84%
2009	-23.22%	+39.51%
2008	-7.80%	-22.08%
2007	+44.10%	+9.29%
2006	+111.81%	+4.01%
2005	-9.66%	-29.24%
2004	-13.36%	-24.71%
2003	-4.97%	+332.39%
2002	-68.69%	-19.54%
2001	+130.55%	-76.42%
2000	+77.49%	+109.45%
1999	-44.34%	+1.60%

IONS vs RMBS Drawdown Comparison

The maximum drawdown for IONS was -91.43%, occurring on Mar 18, 2003. Recovery took 3357 trading sessions.

The maximum drawdown for RMBS was -97.16%, occurring on Jun 26, 2002. Recovery took 6430 trading sessions.

The current IONS drawdown is -38.40%. The current RMBS drawdown is -47.51%.

Rank	IONS	RMBS
#1	-91.43% Mar 6, 2000 - Jul 11, 2013	-97.16% Jun 26, 2000 - Jan 21, 2026
#2	-73.25% Mar 19, 2015 - Mar 14, 2019	-66.16% Mar 13, 2000 - Jun 23, 2000
#3	-70.39% Apr 8, 2019 - Feb 6, 2026	-51.48% Jun 3, 2026 - Jul 29, 2026
#4	-68.14% Dec 2, 1999 - Mar 1, 2000	-36.69% Jan 21, 2026 - Apr 17, 2026
#5	-61.05% Feb 21, 2014 - Dec 10, 2014	-29.75% Apr 24, 2026 - Jun 2, 2026
#6	-38.79% Feb 6, 2026 - Jul 20, 2026	-28.41% Nov 8, 1999 - Feb 14, 2000
#7	-28.35% Jul 12, 2013 - Sep 19, 2013	-14.36% Feb 29, 2000 - Mar 6, 2000
#8	-20.89% Sep 23, 2013 - Nov 27, 2013	-11.61% Feb 15, 2000 - Feb 22, 2000
#9	-19.78% Jan 12, 2015 - Mar 19, 2015	-2.39% Feb 24, 2000 - Feb 28, 2000
#10	-11.84% Dec 12, 2014 - Dec 19, 2014	-1.17% Mar 7, 2000 - Mar 9, 2000
#11	-11.49% Dec 19, 2014 - Jan 5, 2015	-0.90% Feb 22, 2000 - Feb 24, 2000
#12	-8.95% Jan 31, 2014 - Feb 13, 2014	-0.05% Apr 17, 2026 - Apr 21, 2026
#13	-8.58% Nov 11, 1999 - Nov 17, 1999	N/A
#14	-7.67% Jan 22, 2014 - Jan 31, 2014	N/A
#15	-7.49% Dec 23, 2013 - Jan 8, 2014	N/A