IONS vs EXEL

Comparison between Ionis Pharmaceuticals Inc (IONS, Company) and Exelixis Inc (EXEL, Company).

Both IONS and EXEL are from the Healthcare sector.

5-Year PerformanceEXEL has outperformed IONS, delivering a return of +18.7% compared to +16.6%

IONS vs EXEL - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	IONS(COMPANY)	EXEL(COMPANY)
Market Cap	$13B	$13B
Max Drawdown	91.72%	97.38%
Sharpe Ratio	1.74	0.67
5Y Beta	0.74	0.53
Industry	Biotechnology	Biotechnology
P/E Ratio	-72.59	15.79
Forward P/E	96.15	15.36
PEG Ratio	-1.53	0.41
5Y EPS CAGR	-21.44%	72.24%
Debt to Equity	88.01%	0.00%
Free Cash Flow Yield	-7.65%	7.23%
P/S Ratio	11.80	5.29
P/B Ratio	25.72	6.49

Market Cap

IONS

$13B

Winner

EXEL

$13B

Max Drawdown

Winner

IONS

91.72%

EXEL

97.38%

Sharpe Ratio

Winner

IONS

1.74

EXEL

0.67

5Y Beta

IONS

0.74

Winner

EXEL

0.53

Industry

IONS

Biotechnology

EXEL

Biotechnology

P/E Ratio

Winner

IONS

-72.59

EXEL

15.79

Forward P/E

IONS

96.15

Winner

EXEL

15.36

PEG Ratio

Winner

IONS

-1.53

EXEL

0.41

5Y EPS CAGR

IONS

-21.44%

Winner

EXEL

72.24%

Debt to Equity

IONS

88.01%

Winner

EXEL

0.00%

Free Cash Flow Yield

IONS

-7.65%

Winner

EXEL

7.23%

P/S Ratio

IONS

11.80

Winner

EXEL

5.29

P/B Ratio

IONS

25.72

Winner

EXEL

6.49

IONS vs EXEL - Historical Returns

Returns include dividend reinvestment.

Period	IONS	EXEL
1 month	-1.02%	+18.64%
3 months	-0.90%	+27.66%
6 months	-8.81%	+18.80%
1 year	+111.35%	+24.38%
5 years(CAGR)	+16.60%	+18.69%
10 years(CAGR)	+11.86%	+21.82%
Max(CAGR)	+7.55%	+4.99%

IONS

-1.02%

Winner

EXEL

+18.64%

IONS

-0.90%

Winner

EXEL

+27.66%

IONS

-8.81%

Winner

EXEL

+18.80%

Winner

IONS

+111.35%

EXEL

+24.38%

5Y(CAGR)

IONS

+16.60%

Winner

EXEL

+18.69%

10Y(CAGR)

IONS

+11.86%

Winner

EXEL

+21.82%

Max(CAGR)

Winner

IONS

+7.55%

EXEL

+4.99%

IONS vs EXEL - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	IONS	EXEL
2026	-6.51%	+20.93%
2025	+128.05%	+29.14%
2024	-33.88%	+39.16%
2023	+34.62%	+47.18%
2022	+15.86%	-16.37%
2021	-46.41%	-10.96%
2020	-7.14%	+13.65%
2019	+12.35%	-11.59%
2018	+9.77%	-37.36%
2017	+6.25%	+106.38%
2016	-22.45%	+171.58%
2015	+0.58%	+241.82%
2014	+54.85%	-76.70%
2013	+268.21%	+26.92%
2012	+44.00%	-1.93%
2011	-29.93%	-44.26%
2010	-10.20%	+9.47%
2009	-23.22%	+41.19%
2008	-7.80%	-42.56%
2007	+44.10%	-8.87%
2006	+111.81%	-7.60%
2005	-9.66%	+2.39%
2004	-13.36%	+35.71%
2003	-4.97%	-7.35%
2002	-68.69%	-49.40%
2001	+130.55%	+30.97%
2000	+77.49%	-0.81%
1999	-44.34%	N/A

IONS vs EXEL Drawdown Comparison

The maximum drawdown for IONS was -91.43%, occurring on Mar 18, 2003. Recovery took 3357 trading sessions.

The maximum drawdown for EXEL was -97.38%, occurring on Dec 24, 2014. Recovery took 6485 trading sessions.

The current IONS drawdown is -13.90%.

Rank	IONS	EXEL
#1	-91.43% Mar 6, 2000 - Jul 11, 2013	-97.38% Jul 26, 2000 - May 11, 2026
#2	-73.25% Mar 19, 2015 - Mar 14, 2019	-38.22% May 4, 2000 - Jun 5, 2000
#3	-70.39% Apr 8, 2019 - Feb 6, 2026	-9.05% Jun 22, 2000 - Jun 28, 2000
#4	-68.14% Dec 2, 1999 - Mar 1, 2000	-8.99% Jul 12, 2000 - Jul 24, 2000
#5	-61.05% Feb 21, 2014 - Dec 10, 2014	-8.50% Jun 7, 2000 - Jun 21, 2000
#6	-28.35% Jul 12, 2013 - Sep 19, 2013	-6.38% Jun 29, 2000 - Jul 6, 2000
#7	-20.89% Sep 23, 2013 - Nov 27, 2013	-5.66% May 28, 2026 - Jun 3, 2026
#8	-19.78% Jan 12, 2015 - Mar 19, 2015	-5.11% May 13, 2026 - May 28, 2026
#9	-19.45% Feb 6, 2026 - Mar 24, 2026	-2.41% Apr 20, 2000 - Apr 28, 2000
#10	-11.84% Dec 12, 2014 - Dec 19, 2014	-0.81% Apr 17, 2000 - Apr 19, 2000
#11	-11.49% Dec 19, 2014 - Jan 5, 2015	-0.50% May 11, 2026 - May 13, 2026
#12	-8.95% Jan 31, 2014 - Feb 13, 2014	N/A
#13	-8.58% Nov 11, 1999 - Nov 17, 1999	N/A
#14	-7.67% Jan 22, 2014 - Jan 31, 2014	N/A
#15	-7.49% Dec 23, 2013 - Jan 8, 2014	N/A