IONS vs SAIA

Comparison between Ionis Pharmaceuticals Inc (IONS, Company) and Saia Inc (SAIA, Company).

IONS is from the Healthcare sector, while SAIA is from the Industrials sector.

5-Year PerformanceIONS has outperformed SAIA, delivering a return of +16.5% compared to +15.6%

IONS vs SAIA - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	IONS(COMPANY)	SAIA(COMPANY)
Market Cap	$12B	$12B
Max Drawdown	91.72%	80.35%
Sharpe Ratio	1.91	1.27
5Y Beta	0.75	1.43
Industry	Biotechnology	Trucking
P/E Ratio	-71.23	48.73
Forward P/E	90.91	40.82
PEG Ratio	-1.50	2.44
5Y EPS CAGR	-21.44%	11.22%
Debt to Equity	88.01%	4.26%
Free Cash Flow Yield	-7.80%	1.56%
P/S Ratio	11.70	3.81
P/B Ratio	25.24	4.54

Market Cap

Winner

IONS

$12B

SAIA

$12B

Max Drawdown

IONS

91.72%

Winner

SAIA

80.35%

Sharpe Ratio

Winner

IONS

1.91

SAIA

1.27

5Y Beta

Winner

IONS

0.75

SAIA

1.43

Industry

IONS

Biotechnology

SAIA

Trucking

P/E Ratio

Winner

IONS

-71.23

SAIA

48.73

Forward P/E

IONS

90.91

Winner

SAIA

40.82

PEG Ratio

Winner

IONS

-1.50

SAIA

2.44

5Y EPS CAGR

IONS

-21.44%

Winner

SAIA

11.22%

Debt to Equity

IONS

88.01%

Winner

SAIA

4.26%

Free Cash Flow Yield

IONS

-7.80%

Winner

SAIA

1.56%

P/S Ratio

IONS

11.70

Winner

SAIA

3.81

P/B Ratio

IONS

25.24

Winner

SAIA

4.54

IONS vs SAIA - Historical Returns

Returns include dividend reinvestment.

Period	IONS	SAIA
1 month	+5.32%	+5.30%
3 months	-5.62%	+15.77%
6 months	-8.02%	+67.42%
1 year	+128.30%	+70.14%
5 years(CAGR)	+16.45%	+15.63%
10 years(CAGR)	+13.55%	+33.55%
Max(CAGR)	+7.64%	+18.18%

Winner

IONS

+5.32%

SAIA

+5.30%

IONS

-5.62%

Winner

SAIA

+15.77%

IONS

-8.02%

Winner

SAIA

+67.42%

Winner

IONS

+128.30%

SAIA

+70.14%

5Y(CAGR)

Winner

IONS

+16.45%

SAIA

+15.63%

10Y(CAGR)

IONS

+13.55%

Winner

SAIA

+33.55%

Max(CAGR)

IONS

+7.64%

Winner

SAIA

+18.18%

IONS vs SAIA - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	IONS	SAIA
2026	-4.52%	+38.77%
2025	+128.05%	-26.68%
2024	-33.88%	+6.60%
2023	+34.62%	+110.07%
2022	+15.86%	-33.39%
2021	-46.41%	+87.31%
2020	-7.14%	+92.77%
2019	+12.35%	+70.74%
2018	+9.77%	-21.93%
2017	+6.25%	+57.57%
2016	-22.45%	+102.62%
2015	+0.58%	-60.06%
2014	+54.85%	+81.39%
2013	+268.21%	+104.14%
2012	+44.00%	+76.09%
2011	-29.93%	-25.36%
2010	-10.20%	+15.45%
2009	-23.22%	+31.73%
2008	-7.80%	-14.82%
2007	+44.10%	-43.95%
2006	+111.81%	+4.08%
2005	-9.66%	-7.29%
2004	-13.36%	+34.62%
2003	-4.97%	+73.03%
2002	-68.69%	-25.93%
2001	+130.55%	N/A
2000	+77.49%	N/A
1999	-44.34%	N/A

IONS vs SAIA Drawdown Comparison

The maximum drawdown for IONS was -91.43%, occurring on Mar 18, 2003. Recovery took 3357 trading sessions.

The maximum drawdown for SAIA was -80.35%, occurring on Nov 20, 2008. Recovery took 1612 trading sessions.

The current IONS drawdown is -12.06%. The current SAIA drawdown is -22.78%.

Rank	IONS	SAIA
#1	-91.43% Mar 6, 2000 - Jul 11, 2013	-80.35% Oct 16, 2006 - Mar 14, 2013
#2	-73.25% Mar 19, 2015 - Mar 14, 2019	-65.82% Dec 4, 2014 - Aug 31, 2017
#3	-70.39% Apr 8, 2019 - Feb 6, 2026	-60.94% Mar 6, 2024 - Apr 29, 2025
#4	-68.14% Dec 2, 1999 - Mar 1, 2000	-53.15% Nov 17, 2021 - Jul 17, 2023
#5	-61.05% Feb 21, 2014 - Dec 10, 2014	-49.18% Sep 12, 2002 - Jul 2, 2003
#6	-28.35% Jul 12, 2013 - Sep 19, 2013	-44.51% Jun 23, 2004 - Jan 25, 2006
#7	-20.89% Sep 23, 2013 - Nov 27, 2013	-39.57% Jun 12, 2018 - Sep 4, 2019
#8	-19.78% Jan 12, 2015 - Mar 19, 2015	-39.00% Oct 28, 2019 - May 26, 2020
#9	-19.45% Feb 6, 2026 - Mar 24, 2026	-24.09% Mar 15, 2006 - Aug 16, 2006
#10	-11.84% Dec 12, 2014 - Dec 19, 2014	-21.51% Sep 1, 2023 - Dec 21, 2023
#11	-11.49% Dec 19, 2014 - Jan 5, 2015	-21.10% May 7, 2021 - Aug 11, 2021
#12	-8.95% Jan 31, 2014 - Feb 13, 2014	-19.00% Sep 22, 2003 - Dec 2, 2003
#13	-8.58% Nov 11, 1999 - Nov 17, 1999	-18.30% Jul 11, 2013 - Oct 22, 2013
#14	-7.67% Jan 22, 2014 - Jan 31, 2014	-17.02% Jan 25, 2018 - May 21, 2018
#15	-7.49% Dec 23, 2013 - Jan 8, 2014	-14.17% Oct 22, 2013 - Mar 4, 2014