IONS vs ESI

Comparison between Ionis Pharmaceuticals Inc (IONS, Company) and Element Solutions Inc (ESI, Company).

IONS is from the Healthcare sector, while ESI is from the Basic Materials sector.

5-Year PerformanceESI has outperformed IONS, delivering a return of +11.5% compared to +7.1%

IONS vs ESI - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	IONS(COMPANY)	ESI(COMPANY)
Market Cap	$9.36B	$9.35B
Max Drawdown	91.72%	80.66%
Sharpe Ratio	0.80	1.24
5Y Beta	0.66	1.53
Industry	Biotechnology	Specialty Chemicals
P/E Ratio	-22.42	38.74
Forward P/E	90.91	20.49
PEG Ratio	N/A	0.74
Dividend Yield	N/A	0.86%
5Y Dividends CAGR	N/A	20.11%
5Y EPS CAGR	-8.41%	N/A
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-5.99%	-2.29%

Market Cap

Winner

IONS

$9.36B

ESI

$9.35B

Max Drawdown

IONS

91.72%

Winner

ESI

80.66%

Sharpe Ratio

IONS

0.80

Winner

ESI

1.24

5Y Beta

Winner

IONS

0.66

ESI

1.53

Industry

IONS

Biotechnology

ESI

Specialty Chemicals

P/E Ratio

Winner

IONS

-22.42

ESI

38.74

Forward P/E

IONS

90.91

Winner

ESI

20.49

PEG Ratio

IONS

N/A

ESI

0.74

Dividend Yield

IONS

N/A

ESI

0.86%

5Y Dividends CAGR

IONS

N/A

ESI

20.11%

5Y EPS CAGR

IONS

-8.41%

ESI

N/A

Debt to Equity

IONS

0.00%

ESI

0.00%

Free Cash Flow Yield

IONS

-5.99%

Winner

ESI

-2.29%

IONS vs ESI - Historical Returns

Returns include dividend reinvestment.

Period	IONS	ESI
1 month	-1.55%	-1.49%
3 months	-28.00%	-11.63%
6 months	-30.68%	+21.06%
1 year	+29.63%	+54.59%
5 years(CAGR)	+7.08%	+11.52%
10 years(CAGR)	+4.78%	+16.81%
Max(CAGR)	+6.34%	+10.30%

IONS

-1.55%

Winner

ESI

-1.49%

IONS

-28.00%

Winner

ESI

-11.63%

IONS

-30.68%

Winner

ESI

+21.06%

IONS

+29.63%

Winner

ESI

+54.59%

5Y(CAGR)

IONS

+7.08%

Winner

ESI

+11.52%

10Y(CAGR)

IONS

+4.78%

Winner

ESI

+16.81%

Max(CAGR)

IONS

+6.34%

Winner

ESI

+10.30%

IONS vs ESI - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	IONS	ESI
2026	-29.87%	+51.02%
2025	+128.05%	+0.60%
2024	-33.88%	+12.89%
2023	+34.62%	+29.84%
2022	+15.86%	-24.79%
2021	-46.41%	+41.96%
2020	-7.14%	+52.07%
2019	+12.35%	+9.98%
2018	+9.77%	-0.10%
2017	+6.25%	+0.92%
2016	-22.45%	-19.72%
2015	+0.58%	-44.39%
2014	+54.85%	+65.86%
2013	+268.21%	+16.67%
2012	+44.00%	N/A
2011	-29.93%	N/A
2010	-10.20%	N/A
2009	-23.22%	N/A
2008	-7.80%	N/A
2007	+44.10%	N/A
2006	+111.81%	N/A
2005	-9.66%	N/A
2004	-13.36%	N/A
2003	-4.97%	N/A
2002	-68.69%	N/A
2001	+130.55%	N/A
2000	+77.49%	N/A
1999	-44.34%	N/A

IONS vs ESI Drawdown Comparison

The maximum drawdown for IONS was -91.43%, occurring on Mar 18, 2003. Recovery took 3357 trading sessions.

The maximum drawdown for ESI was -80.66%, occurring on Feb 11, 2016. Recovery took 2511 trading sessions.

The current IONS drawdown is -35.41%. The current ESI drawdown is -20.53%.

Rank	IONS	ESI
#1	-91.43% Mar 6, 2000 - Jul 11, 2013	-80.66% Jun 26, 2014 - Jun 18, 2024
#2	-73.25% Mar 19, 2015 - Mar 14, 2019	-39.98% Nov 25, 2024 - Jan 15, 2026
#3	-70.39% Apr 8, 2019 - Feb 6, 2026	-29.13% Jun 22, 2026 - Jul 29, 2026
#4	-68.14% Dec 2, 1999 - Mar 1, 2000	-17.84% Feb 24, 2026 - Apr 8, 2026
#5	-61.05% Feb 21, 2014 - Dec 10, 2014	-15.19% Jul 16, 2024 - Nov 6, 2024
#6	-40.15% Feb 6, 2026 - Jul 31, 2026	-15.12% Mar 4, 2014 - May 16, 2014
#7	-28.35% Jul 12, 2013 - Sep 19, 2013	-12.38% May 11, 2026 - Jun 15, 2026
#8	-20.89% Sep 23, 2013 - Nov 27, 2013	-7.18% Jan 23, 2014 - Feb 6, 2014
#9	-19.78% Jan 12, 2015 - Mar 19, 2015	-6.68% Jun 2, 2014 - Jun 9, 2014
#10	-11.84% Dec 12, 2014 - Dec 19, 2014	-6.59% Jun 12, 2014 - Jun 26, 2014
#11	-11.49% Dec 19, 2014 - Jan 5, 2015	-6.39% Feb 4, 2026 - Feb 6, 2026
#12	-8.95% Jan 31, 2014 - Feb 13, 2014	-4.45% May 6, 2026 - May 11, 2026
#13	-8.58% Nov 11, 1999 - Nov 17, 1999	-4.12% Nov 6, 2024 - Nov 22, 2024
#14	-7.67% Jan 22, 2014 - Jan 31, 2014	-4.09% Jun 18, 2024 - Jul 12, 2024
#15	-7.49% Dec 23, 2013 - Jan 8, 2014	-3.94% Apr 27, 2026 - Apr 29, 2026