IONS vs ALGN

Comparison between Ionis Pharmaceuticals Inc (IONS, Company) and Align Technology Inc (ALGN, Company).

Both IONS and ALGN are from the Healthcare sector.

5-Year PerformanceIONS has outperformed ALGN, delivering a return of +14.1% compared to -22.1%

IONS vs ALGN - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	IONS(COMPANY)	ALGN(COMPANY)
Market Cap	$12B	$12B
Max Drawdown	91.72%	92.30%
Sharpe Ratio	1.65	0.12
5Y Beta	0.73	1.33
Industry	Biotechnology	Medical Instruments & Supplies
P/E Ratio	-69.58	28.49
Forward P/E	90.91	15.38
PEG Ratio	-1.47	3.44
5Y EPS CAGR	-21.44%	0.63%
Debt to Equity	88.01%	0.00%
Free Cash Flow Yield	-7.98%	4.78%
P/S Ratio	11.72	3.11
P/B Ratio	25.08	3.07

Market Cap

IONS

$12B

Winner

ALGN

$12B

Max Drawdown

Winner

IONS

91.72%

ALGN

92.30%

Sharpe Ratio

Winner

IONS

1.65

ALGN

0.12

5Y Beta

Winner

IONS

0.73

ALGN

1.33

Industry

IONS

Biotechnology

ALGN

Medical Instruments & Supplies

P/E Ratio

Winner

IONS

-69.58

ALGN

28.49

Forward P/E

IONS

90.91

Winner

ALGN

15.38

PEG Ratio

Winner

IONS

-1.47

ALGN

3.44

5Y EPS CAGR

IONS

-21.44%

Winner

ALGN

0.63%

Debt to Equity

IONS

88.01%

Winner

ALGN

0.00%

Free Cash Flow Yield

IONS

-7.98%

Winner

ALGN

4.78%

P/S Ratio

IONS

11.72

Winner

ALGN

3.11

P/B Ratio

IONS

25.08

Winner

ALGN

3.07

IONS vs ALGN - Historical Returns

Returns include dividend reinvestment.

Period	IONS	ALGN
1 month	-3.37%	+5.46%
3 months	+1.29%	+4.74%
6 months	-9.34%	+5.69%
1 year	+105.71%	-3.77%
5 years(CAGR)	+14.07%	-22.14%
10 years(CAGR)	+13.07%	+8.38%
Max(CAGR)	+7.47%	+9.66%

IONS

-3.37%

Winner

ALGN

+5.46%

IONS

+1.29%

Winner

ALGN

+4.74%

IONS

-9.34%

Winner

ALGN

+5.69%

Winner

IONS

+105.71%

ALGN

-3.77%

5Y(CAGR)

Winner

IONS

+14.07%

ALGN

-22.14%

10Y(CAGR)

Winner

IONS

+13.07%

ALGN

+8.38%

Max(CAGR)

IONS

+7.47%

Winner

ALGN

+9.66%

IONS vs ALGN - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	IONS	ALGN
2026	-8.03%	+12.06%
2025	+128.05%	-25.10%
2024	-33.88%	-22.46%
2023	+34.62%	+29.07%
2022	+15.86%	-67.46%
2021	-46.41%	+24.83%
2020	-7.14%	+88.37%
2019	+12.35%	+38.06%
2018	+9.77%	-6.76%
2017	+6.25%	+129.16%
2016	-22.45%	+49.57%
2015	+0.58%	+17.17%
2014	+54.85%	-1.84%
2013	+268.21%	+101.20%
2012	+44.00%	+15.87%
2011	-29.93%	+19.40%
2010	-10.20%	+5.62%
2009	-23.22%	+100.45%
2008	-7.80%	-46.87%
2007	+44.10%	+24.94%
2006	+111.81%	+122.45%
2005	-9.66%	-38.73%
2004	-13.36%	-35.59%
2003	-4.97%	+502.77%
2002	-68.69%	-35.79%
2001	+130.55%	-73.34%
2000	+77.49%	N/A
1999	-44.34%	N/A

IONS vs ALGN Drawdown Comparison

The maximum drawdown for IONS was -91.43%, occurring on Mar 18, 2003. Recovery took 3357 trading sessions.

The maximum drawdown for ALGN was -92.30%, occurring on Nov 13, 2002. Recovery took 692 trading sessions.

The current IONS drawdown is -15.29%. The current ALGN drawdown is -76.05%.

Rank	IONS	ALGN
#1	-91.43% Mar 6, 2000 - Jul 11, 2013	-92.30% Jan 30, 2001 - Nov 3, 2003
#2	-73.25% Mar 19, 2015 - Mar 14, 2019	-82.89% Sep 8, 2021 - Sep 25, 2025
#3	-70.39% Apr 8, 2019 - Feb 6, 2026	-82.58% Oct 24, 2007 - Apr 24, 2012
#4	-68.14% Dec 2, 1999 - Mar 1, 2000	-75.18% Apr 19, 2004 - Apr 26, 2007
#5	-61.05% Feb 21, 2014 - Dec 10, 2014	-64.95% Sep 25, 2018 - Oct 22, 2020
#6	-28.35% Jul 12, 2013 - Sep 19, 2013	-35.18% Sep 13, 2012 - Jul 10, 2013
#7	-20.89% Sep 23, 2013 - Nov 27, 2013	-30.62% Jan 17, 2014 - Jun 16, 2015
#8	-19.78% Jan 12, 2015 - Mar 19, 2015	-22.28% Jan 26, 2018 - May 11, 2018
#9	-19.45% Feb 6, 2026 - Mar 24, 2026	-20.05% Feb 5, 2021 - Apr 27, 2021
#10	-11.84% Dec 12, 2014 - Dec 19, 2014	-18.56% Jul 25, 2007 - Oct 4, 2007
#11	-11.49% Dec 19, 2014 - Jan 5, 2015	-18.32% Jul 20, 2015 - Oct 23, 2015
#12	-8.95% Jan 31, 2014 - Feb 13, 2014	-17.71% Jan 26, 2004 - Apr 12, 2004
#13	-8.58% Nov 11, 1999 - Nov 17, 1999	-17.21% Nov 28, 2017 - Jan 17, 2018
#14	-7.67% Jan 22, 2014 - Jan 31, 2014	-14.67% Dec 1, 2003 - Jan 7, 2004
#15	-7.49% Dec 23, 2013 - Jan 8, 2014	-14.09% Oct 26, 2015 - Mar 2, 2016