IONS vs AG

Comparison between Ionis Pharmaceuticals Inc (IONS, Company) and First Majestic Silver Corporation (AG, Company).

IONS is from the Healthcare sector, while AG is from the Basic Materials sector.

5-Year PerformanceAG has outperformed IONS, delivering a return of +8.3% compared to +7.1%

IONS vs AG - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	IONS(COMPANY)	AG(COMPANY)
Market Cap	$9.36B	$9.40B
Max Drawdown	91.72%	90.20%
Sharpe Ratio	0.80	1.37
5Y Beta	0.66	1.43
Industry	Biotechnology	Silver
P/E Ratio	-22.42	26.93
Forward P/E	90.91	20.41
Dividend Yield	N/A	0.24%
5Y Dividends CAGR	N/A	51.06%
5Y EPS CAGR	-8.41%	14.30%
Debt to Equity	0.00%	11.17%
Free Cash Flow Yield	-5.99%	7.40%

Market Cap

IONS

$9.36B

Winner

$9.40B

Max Drawdown

IONS

91.72%

Winner

90.20%

Sharpe Ratio

IONS

0.80

Winner

1.37

5Y Beta

Winner

IONS

0.66

1.43

Industry

IONS

Biotechnology

Silver

P/E Ratio

Winner

IONS

-22.42

26.93

Forward P/E

IONS

90.91

Winner

20.41

Dividend Yield

IONS

N/A

0.24%

5Y Dividends CAGR

IONS

N/A

51.06%

5Y EPS CAGR

IONS

-8.41%

Winner

14.30%

Debt to Equity

Winner

IONS

0.00%

11.17%

Free Cash Flow Yield

IONS

-5.99%

Winner

7.40%

IONS vs AG - Historical Returns

Returns include dividend reinvestment.

Period	IONS	AG
1 month	-1.55%	+14.39%
3 months	-28.00%	-21.70%
6 months	-30.68%	-18.20%
1 year	+29.63%	+110.28%
5 years(CAGR)	+7.08%	+8.34%
10 years(CAGR)	+4.78%	+0.50%
Max(CAGR)	+6.34%	+8.38%

IONS

-1.55%

Winner

+14.39%

IONS

-28.00%

Winner

-21.70%

IONS

-30.68%

Winner

-18.20%

IONS

+29.63%

Winner

+110.28%

5Y(CAGR)

IONS

+7.08%

Winner

+8.34%

10Y(CAGR)

Winner

IONS

+4.78%

+0.50%

Max(CAGR)

IONS

+6.34%

Winner

+8.38%

IONS vs AG - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	IONS	AG
2026	-29.87%	+16.94%
2025	+128.05%	+180.79%
2024	-33.88%	-7.92%
2023	+34.62%	-26.61%
2022	+15.86%	-23.42%
2021	-46.41%	-21.89%
2020	-7.14%	+9.98%
2019	+12.35%	+103.65%
2018	+9.77%	-18.42%
2017	+6.25%	-16.58%
2016	-22.45%	+123.10%
2015	+0.58%	-37.36%
2014	+54.85%	-51.96%
2013	+268.21%	-53.69%
2012	+44.00%	+14.46%
2011	-29.93%	+7.95%
2010	-10.20%	+254.15%
2009	-23.22%	+94.09%
2008	-7.80%	-62.37%
2007	+44.10%	+2.20%
2006	+111.81%	+7.18%
2005	-9.66%	N/A
2004	-13.36%	N/A
2003	-4.97%	N/A
2002	-68.69%	N/A
2001	+130.55%	N/A
2000	+77.49%	N/A
1999	-44.34%	N/A

IONS vs AG Drawdown Comparison

The maximum drawdown for IONS was -91.43%, occurring on Mar 18, 2003. Recovery took 3357 trading sessions.

The maximum drawdown for AG was -90.20%, occurring on Jan 19, 2016. Recovery took 3722 trading sessions.

The current IONS drawdown is -35.41%. The current AG drawdown is -41.34%.

Rank	IONS	AG
#1	-91.43% Mar 6, 2000 - Jul 11, 2013	-90.20% Apr 5, 2011 - Jan 23, 2026
#2	-73.25% Mar 19, 2015 - Mar 14, 2019	-87.80% Mar 3, 2008 - Sep 20, 2010
#3	-70.39% Apr 8, 2019 - Feb 6, 2026	-53.01% Feb 27, 2026 - Jul 31, 2026
#4	-68.14% Dec 2, 1999 - Mar 1, 2000	-46.53% Feb 26, 2007 - Mar 3, 2008
#5	-61.05% Feb 21, 2014 - Dec 10, 2014	-32.76% Jan 3, 2011 - Mar 1, 2011
#6	-40.15% Feb 6, 2026 - Jul 31, 2026	-22.80% Jan 28, 2026 - Feb 20, 2026
#7	-28.35% Jul 12, 2013 - Sep 19, 2013	-17.70% Mar 8, 2011 - Mar 21, 2011
#8	-20.89% Sep 23, 2013 - Nov 27, 2013	-16.03% Nov 8, 2010 - Nov 22, 2010
#9	-19.78% Jan 12, 2015 - Mar 19, 2015	-15.35% Jan 18, 2007 - Feb 16, 2007
#10	-11.84% Dec 12, 2014 - Dec 19, 2014	-15.18% Oct 13, 2010 - Oct 29, 2010
#11	-11.49% Dec 19, 2014 - Jan 5, 2015	-12.71% Dec 14, 2010 - Dec 29, 2010
#12	-8.95% Jan 31, 2014 - Feb 13, 2014	-10.11% Jan 3, 2007 - Jan 12, 2007
#13	-8.58% Nov 11, 1999 - Nov 17, 1999	-9.53% Dec 6, 2010 - Dec 14, 2010
#14	-7.67% Jan 22, 2014 - Jan 31, 2014	-7.61% Nov 30, 2006 - Dec 15, 2006
#15	-7.49% Dec 23, 2013 - Jan 8, 2014	-4.00% Nov 24, 2010 - Nov 30, 2010