IONS vs AEIS

Comparison between Ionis Pharmaceuticals Inc (IONS, Company) and Advanced Energy Industries Inc (AEIS, Company).

IONS is from the Healthcare sector, while AEIS is from the Industrials sector.

5-Year PerformanceAEIS has outperformed IONS, delivering a return of +30.2% compared to +14.6%

IONS vs AEIS - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	IONS(COMPANY)	AEIS(COMPANY)
Market Cap	$13B	$13B
Max Drawdown	91.72%	92.51%
Sharpe Ratio	1.94	2.36
5Y Beta	0.74	1.95
Industry	Biotechnology	Electrical Equipment & Parts
P/E Ratio	-73.64	67.36
Forward P/E	90.91	41.67
PEG Ratio	-1.55	0.42
Dividend Yield	N/A	0.12%
5Y Dividends CAGR	N/A	37.97%
5Y EPS CAGR	-21.44%	4.44%
Debt to Equity	88.01%	82.09%
Free Cash Flow Yield	-7.54%	0.53%
P/S Ratio	11.83	6.77
P/B Ratio	25.46	9.81

Market Cap

IONS

$13B

Winner

AEIS

$13B

Max Drawdown

Winner

IONS

91.72%

AEIS

92.51%

Sharpe Ratio

IONS

1.94

Winner

AEIS

2.36

5Y Beta

Winner

IONS

0.74

AEIS

1.95

Industry

IONS

Biotechnology

AEIS

Electrical Equipment & Parts

P/E Ratio

Winner

IONS

-73.64

AEIS

67.36

Forward P/E

IONS

90.91

Winner

AEIS

41.67

PEG Ratio

Winner

IONS

-1.55

AEIS

0.42

Dividend Yield

IONS

N/A

AEIS

0.12%

5Y Dividends CAGR

IONS

N/A

AEIS

37.97%

5Y EPS CAGR

IONS

-21.44%

Winner

AEIS

4.44%

Debt to Equity

IONS

88.01%

Winner

AEIS

82.09%

Free Cash Flow Yield

IONS

-7.54%

Winner

AEIS

0.53%

P/S Ratio

IONS

11.83

Winner

AEIS

6.77

P/B Ratio

IONS

25.46

Winner

AEIS

9.81

IONS vs AEIS - Historical Returns

Returns include dividend reinvestment.

Period	IONS	AEIS
1 month	-1.41%	-10.66%
3 months	-6.10%	+9.68%
6 months	+5.77%	+70.32%
1 year	+132.15%	+190.45%
5 years(CAGR)	+14.63%	+30.24%
10 years(CAGR)	+9.19%	+26.05%
Max(CAGR)	+7.63%	+8.28%

Winner

IONS

-1.41%

AEIS

-10.66%

IONS

-6.10%

Winner

AEIS

+9.68%

IONS

+5.77%

Winner

AEIS

+70.32%

IONS

+132.15%

Winner

AEIS

+190.45%

5Y(CAGR)

IONS

+14.63%

Winner

AEIS

+30.24%

10Y(CAGR)

IONS

+9.19%

Winner

AEIS

+26.05%

Max(CAGR)

IONS

+7.63%

Winner

AEIS

+8.28%

IONS vs AEIS - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	IONS	AEIS
2026	-5.01%	+55.28%
2025	+128.05%	+82.04%
2024	-33.88%	+9.24%
2023	+34.62%	+27.85%
2022	+15.86%	-7.15%
2021	-46.41%	-6.68%
2020	-7.14%	+35.21%
2019	+12.35%	+64.24%
2018	+9.77%	-38.15%
2017	+6.25%	+23.14%
2016	-22.45%	+102.25%
2015	+0.58%	+16.58%
2014	+54.85%	+3.58%
2013	+268.21%	+59.86%
2012	+44.00%	+25.31%
2011	-29.93%	-22.47%
2010	-10.20%	-12.40%
2009	-23.22%	+51.25%
2008	-7.80%	-22.02%
2007	+44.10%	-30.24%
2006	+111.81%	+56.47%
2005	-9.66%	+33.22%
2004	-13.36%	-65.39%
2003	-4.97%	+84.36%
2002	-68.69%	-52.71%
2001	+130.55%	+32.87%
2000	+77.49%	-50.42%
1999	-44.34%	+15.53%

IONS vs AEIS Drawdown Comparison

The maximum drawdown for IONS was -91.43%, occurring on Mar 18, 2003. Recovery took 3357 trading sessions.

The maximum drawdown for AEIS was -92.51%, occurring on Mar 9, 2009. Recovery took 4316 trading sessions.

The current IONS drawdown is -12.51%. The current AEIS drawdown is -11.43%.

Rank	IONS	AEIS
#1	-91.43% Mar 6, 2000 - Jul 11, 2013	-92.51% Mar 1, 2000 - Apr 27, 2017
#2	-73.25% Mar 19, 2015 - Mar 14, 2019	-62.28% Oct 27, 2017 - Nov 23, 2020
#3	-70.39% Apr 8, 2019 - Feb 6, 2026	-43.73% Jan 19, 2021 - Jul 31, 2023
#4	-68.14% Dec 2, 1999 - Mar 1, 2000	-39.87% Feb 19, 2025 - Jun 24, 2025
#5	-61.05% Feb 21, 2014 - Dec 10, 2014	-32.81% Aug 1, 2023 - Jan 21, 2025
#6	-28.35% Jul 12, 2013 - Sep 19, 2013	-24.20% Jun 8, 2017 - Oct 12, 2017
#7	-20.89% Sep 23, 2013 - Nov 27, 2013	-23.57% Nov 2, 1999 - Dec 22, 1999
#8	-19.78% Jan 12, 2015 - Mar 19, 2015	-20.17% Jan 26, 2000 - Feb 16, 2000
#9	-19.45% Feb 6, 2026 - Mar 24, 2026	-16.35% Nov 5, 2025 - Jan 5, 2026
#10	-11.84% Dec 12, 2014 - Dec 19, 2014	-16.30% Mar 24, 2026 - Apr 8, 2026
#11	-11.49% Dec 19, 2014 - Jan 5, 2015	-14.58% Mar 2, 2026 - Mar 24, 2026
#12	-8.95% Jan 31, 2014 - Feb 13, 2014	-12.84% Jan 21, 2025 - Feb 19, 2025
#13	-8.58% Nov 11, 1999 - Nov 17, 1999	-12.82% May 1, 2026 - May 13, 2026
#14	-7.67% Jan 22, 2014 - Jan 31, 2014	-11.29% Dec 31, 1999 - Jan 18, 2000
#15	-7.49% Dec 23, 2013 - Jan 8, 2014	-10.57% Aug 13, 2025 - Sep 18, 2025