GKOS vs PTGX

Comparison between Glaukos Corporation (GKOS, Company) and Protagonist Therapeutics Inc (PTGX, Company).

Both GKOS and PTGX are from the Healthcare sector.

5-Year PerformancePTGX has outperformed GKOS, delivering a return of +23.2% compared to +12.5%

GKOS vs PTGX - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	GKOS(COMPANY)	PTGX(COMPANY)
Market Cap	$8.03B	$8.04B
Max Drawdown	69.57%	85.79%
Sharpe Ratio	0.73	1.77
5Y Beta	1.30	0.24
Industry	Medical Devices	Biotechnology
P/E Ratio	-41.82	-68.02
Forward P/E	2000.00	25.97
PEG Ratio	-0.87	N/A
5Y EPS CAGR	12.32%	1.43%
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-0.23%	-1.47%

Market Cap

GKOS

$8.03B

Winner

PTGX

$8.04B

Max Drawdown

Winner

GKOS

69.57%

PTGX

85.79%

Sharpe Ratio

GKOS

0.73

Winner

PTGX

1.77

5Y Beta

GKOS

1.30

Winner

PTGX

0.24

Industry

GKOS

Medical Devices

PTGX

Biotechnology

P/E Ratio

GKOS

-41.82

Winner

PTGX

-68.02

Forward P/E

GKOS

2000.00

Winner

PTGX

25.97

PEG Ratio

GKOS

-0.87

PTGX

N/A

5Y EPS CAGR

Winner

GKOS

12.32%

PTGX

1.43%

Debt to Equity

GKOS

0.00%

PTGX

0.00%

Free Cash Flow Yield

Winner

GKOS

-0.23%

PTGX

-1.47%

GKOS vs PTGX - Historical Returns

Returns include dividend reinvestment.

Period	GKOS	PTGX
1 month	+33.97%	+41.18%
3 months	+31.60%	+26.83%
6 months	+34.04%	+50.97%
1 year	+43.21%	+159.66%
5 years(CAGR)	+12.48%	+23.21%
10 years(CAGR)	+17.61%	+27.73%
Max(CAGR)	+15.20%	+27.73%

GKOS

+33.97%

Winner

PTGX

+41.18%

Winner

GKOS

+31.60%

PTGX

+26.83%

GKOS

+34.04%

Winner

PTGX

+50.97%

GKOS

+43.21%

Winner

PTGX

+159.66%

5Y(CAGR)

GKOS

+12.48%

Winner

PTGX

+23.21%

10Y(CAGR)

GKOS

+17.61%

Winner

PTGX

+27.73%

Max(CAGR)

GKOS

+15.20%

Winner

PTGX

+27.73%

GKOS vs PTGX - Annual Returns (2015 - 2026)

Returns include dividend reinvestment.

Year	GKOS	PTGX
2026	+34.04%	+50.97%
2025	-24.57%	+124.06%
2024	+94.53%	+64.82%
2023	+81.15%	+112.71%
2022	-7.89%	-69.11%
2021	-36.90%	+74.49%
2020	+38.27%	+190.91%
2019	+1.34%	+2.32%
2018	+107.42%	-68.18%
2017	-23.93%	-1.79%
2016	+43.82%	+87.95%
2015	-20.92%	N/A

GKOS vs PTGX Drawdown Comparison

The maximum drawdown for GKOS was -69.57%, occurring on Mar 20, 2020. Recovery took 366 trading sessions.

The maximum drawdown for PTGX was -85.79%, occurring on Jun 13, 2022. Recovery took 882 trading sessions.

The current GKOS drawdown is -7.95%.

Rank	GKOS	PTGX
#1	-69.57% Aug 1, 2019 - Jan 13, 2021	-85.79% Sep 1, 2021 - Mar 10, 2025
#2	-64.32% Apr 28, 2021 - Apr 8, 2024	-82.13% Dec 5, 2016 - Feb 16, 2021
#3	-55.00% Aug 18, 2015 - Jul 21, 2016	-31.58% Mar 11, 2025 - Aug 27, 2025
#4	-53.68% Jan 23, 2025 - Oct 24, 2025	-20.33% Oct 17, 2016 - Nov 10, 2016
#5	-53.09% Apr 3, 2017 - Aug 29, 2018	-19.04% Mar 19, 2021 - May 18, 2021
#6	-25.77% Aug 31, 2018 - Feb 12, 2019	-16.38% Dec 12, 2025 - Mar 9, 2026
#7	-22.03% Sep 27, 2016 - Jan 12, 2017	-15.52% Oct 10, 2025 - Nov 24, 2025
#8	-21.05% Mar 21, 2019 - Jul 31, 2019	-12.77% Feb 16, 2021 - Mar 2, 2021
#9	-17.93% Mar 1, 2021 - Apr 28, 2021	-12.03% Apr 17, 2026 - Jun 11, 2026
#10	-17.27% Jul 27, 2016 - Sep 14, 2016	-11.53% Aug 19, 2016 - Aug 31, 2016
#11	-11.05% Mar 2, 2017 - Mar 16, 2017	-9.62% Jun 8, 2021 - Jun 11, 2021
#12	-10.99% Feb 28, 2019 - Mar 19, 2019	-8.53% Aug 27, 2025 - Sep 18, 2025
#13	-10.31% Jun 25, 2015 - Jul 17, 2015	-7.43% Mar 31, 2026 - Apr 15, 2026
#14	-10.20% Aug 28, 2024 - Oct 29, 2024	-7.20% Jun 14, 2021 - Jun 16, 2021
#15	-9.60% Jul 16, 2024 - Aug 16, 2024	-6.02% Nov 26, 2025 - Dec 8, 2025