EXEL vs IONS

Comparison between Exelixis Inc (EXEL, Company) and Ionis Pharmaceuticals Inc (IONS, Company).

Both EXEL and IONS are from the Healthcare sector.

5-Year PerformanceEXEL has outperformed IONS, delivering a return of +18.7% compared to +16.6%

EXEL vs IONS - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	EXEL(COMPANY)	IONS(COMPANY)
Market Cap	$13B	$13B
Max Drawdown	97.38%	91.72%
Sharpe Ratio	0.67	1.74
5Y Beta	0.53	0.74
Industry	Biotechnology	Biotechnology
P/E Ratio	15.79	-72.59
Forward P/E	15.36	96.15
PEG Ratio	0.41	-1.53
5Y EPS CAGR	72.24%	-21.44%
Debt to Equity	0.00%	88.01%
Free Cash Flow Yield	7.23%	-7.65%
P/S Ratio	5.29	11.80
P/B Ratio	6.49	25.72

Market Cap

Winner

EXEL

$13B

IONS

$13B

Max Drawdown

EXEL

97.38%

Winner

IONS

91.72%

Sharpe Ratio

EXEL

0.67

Winner

IONS

1.74

5Y Beta

Winner

EXEL

0.53

IONS

0.74

Industry

EXEL

Biotechnology

IONS

Biotechnology

P/E Ratio

EXEL

15.79

Winner

IONS

-72.59

Forward P/E

Winner

EXEL

15.36

IONS

96.15

PEG Ratio

EXEL

0.41

Winner

IONS

-1.53

5Y EPS CAGR

Winner

EXEL

72.24%

IONS

-21.44%

Debt to Equity

Winner

EXEL

0.00%

IONS

88.01%

Free Cash Flow Yield

Winner

EXEL

7.23%

IONS

-7.65%

P/S Ratio

Winner

EXEL

5.29

IONS

11.80

P/B Ratio

Winner

EXEL

6.49

IONS

25.72

EXEL vs IONS - Historical Returns

Returns include dividend reinvestment.

Period	EXEL	IONS
1 month	+18.64%	-1.02%
3 months	+27.66%	-0.90%
6 months	+18.80%	-8.81%
1 year	+24.38%	+111.35%
5 years(CAGR)	+18.69%	+16.60%
10 years(CAGR)	+21.82%	+11.86%
Max(CAGR)	+4.99%	+7.55%

Winner

EXEL

+18.64%

IONS

-1.02%

Winner

EXEL

+27.66%

IONS

-0.90%

Winner

EXEL

+18.80%

IONS

-8.81%

EXEL

+24.38%

Winner

IONS

+111.35%

5Y(CAGR)

Winner

EXEL

+18.69%

IONS

+16.60%

10Y(CAGR)

Winner

EXEL

+21.82%

IONS

+11.86%

Max(CAGR)

EXEL

+4.99%

Winner

IONS

+7.55%

EXEL vs IONS - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	EXEL	IONS
2026	+20.93%	-6.51%
2025	+29.14%	+128.05%
2024	+39.16%	-33.88%
2023	+47.18%	+34.62%
2022	-16.37%	+15.86%
2021	-10.96%	-46.41%
2020	+13.65%	-7.14%
2019	-11.59%	+12.35%
2018	-37.36%	+9.77%
2017	+106.38%	+6.25%
2016	+171.58%	-22.45%
2015	+241.82%	+0.58%
2014	-76.70%	+54.85%
2013	+26.92%	+268.21%
2012	-1.93%	+44.00%
2011	-44.26%	-29.93%
2010	+9.47%	-10.20%
2009	+41.19%	-23.22%
2008	-42.56%	-7.80%
2007	-8.87%	+44.10%
2006	-7.60%	+111.81%
2005	+2.39%	-9.66%
2004	+35.71%	-13.36%
2003	-7.35%	-4.97%
2002	-49.40%	-68.69%
2001	+30.97%	+130.55%
2000	-0.81%	+77.49%
1999	N/A	-44.34%

EXEL vs IONS Drawdown Comparison

The maximum drawdown for EXEL was -97.38%, occurring on Dec 24, 2014. Recovery took 6485 trading sessions.

The maximum drawdown for IONS was -91.43%, occurring on Mar 18, 2003. Recovery took 3357 trading sessions.

The current IONS drawdown is -13.90%.

Rank	EXEL	IONS
#1	-97.38% Jul 26, 2000 - May 11, 2026	-91.43% Mar 6, 2000 - Jul 11, 2013
#2	-38.22% May 4, 2000 - Jun 5, 2000	-73.25% Mar 19, 2015 - Mar 14, 2019
#3	-9.05% Jun 22, 2000 - Jun 28, 2000	-70.39% Apr 8, 2019 - Feb 6, 2026
#4	-8.99% Jul 12, 2000 - Jul 24, 2000	-68.14% Dec 2, 1999 - Mar 1, 2000
#5	-8.50% Jun 7, 2000 - Jun 21, 2000	-61.05% Feb 21, 2014 - Dec 10, 2014
#6	-6.38% Jun 29, 2000 - Jul 6, 2000	-28.35% Jul 12, 2013 - Sep 19, 2013
#7	-5.66% May 28, 2026 - Jun 3, 2026	-20.89% Sep 23, 2013 - Nov 27, 2013
#8	-5.11% May 13, 2026 - May 28, 2026	-19.78% Jan 12, 2015 - Mar 19, 2015
#9	-2.41% Apr 20, 2000 - Apr 28, 2000	-19.45% Feb 6, 2026 - Mar 24, 2026
#10	-0.81% Apr 17, 2000 - Apr 19, 2000	-11.84% Dec 12, 2014 - Dec 19, 2014
#11	-0.50% May 11, 2026 - May 13, 2026	-11.49% Dec 19, 2014 - Jan 5, 2015
#12	N/A	-8.95% Jan 31, 2014 - Feb 13, 2014
#13	N/A	-8.58% Nov 11, 1999 - Nov 17, 1999
#14	N/A	-7.67% Jan 22, 2014 - Jan 31, 2014
#15	N/A	-7.49% Dec 23, 2013 - Jan 8, 2014