DNLI vs USLM

Comparison between Denali Therapeutics Inc (DNLI, Company) and United States Lime & Minerals Inc (USLM, Company).

DNLI is from the Healthcare sector, while USLM is from the Basic Materials sector.

5-Year PerformanceUSLM has outperformed DNLI, delivering a return of +32.5% compared to -21.1%

DNLI vs USLM - Performance Comparison

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Key Characteristics

Financial metrics and valuation ratios

Metric	DNLI(COMPANY)	USLM(COMPANY)
Market Cap	$2.99B	$2.99B
Max Drawdown	87.74%	64.71%
Sharpe Ratio	0.84	0.23
5Y Beta	1.56	1.29
Industry	Biotechnology	Building Materials
P/E Ratio	-5.62	22.20
Forward P/E	N/A	15.24
PEG Ratio	-0.88	0.62
Dividend Yield	N/A	0.23%
5Y Dividends CAGR	N/A	18.57%
5Y EPS CAGR	N/A	38.71%
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-14.12%	3.06%
P/S Ratio	3643.65	8.09
P/B Ratio	3.10	4.44

Market Cap

Winner

DNLI

$2.99B

USLM

$2.99B

Max Drawdown

DNLI

87.74%

Winner

USLM

64.71%

Sharpe Ratio

Winner

DNLI

0.84

USLM

0.23

5Y Beta

DNLI

1.56

Winner

USLM

1.29

Industry

DNLI

Biotechnology

USLM

Building Materials

P/E Ratio

Winner

DNLI

-5.62

USLM

22.20

Forward P/E

DNLI

N/A

USLM

15.24

PEG Ratio

Winner

DNLI

-0.88

USLM

0.62

Dividend Yield

DNLI

N/A

USLM

0.23%

5Y Dividends CAGR

DNLI

N/A

USLM

18.57%

5Y EPS CAGR

DNLI

N/A

USLM

38.71%

Debt to Equity

DNLI

0.00%

USLM

0.00%

Free Cash Flow Yield

DNLI

-14.12%

Winner

USLM

3.06%

P/S Ratio

DNLI

3643.65

Winner

USLM

8.09

P/B Ratio

Winner

DNLI

3.10

USLM

4.44

DNLI vs USLM - Historical Returns

Returns include dividend reinvestment.

Period	DNLI	USLM
1 month	+1.35%	-12.85%
3 months	-4.58%	-1.92%
6 months	+4.18%	-7.50%
1 year	+52.99%	+6.53%
5 years(CAGR)	-21.07%	+32.54%
10 years(CAGR)	-0.70%	+28.20%
Max(CAGR)	-0.70%	+18.41%

Winner

DNLI

+1.35%

USLM

-12.85%

DNLI

-4.58%

Winner

USLM

-1.92%

Winner

DNLI

+4.18%

USLM

-7.50%

Winner

DNLI

+52.99%

USLM

+6.53%

5Y(CAGR)

DNLI

-21.07%

Winner

USLM

+32.54%

10Y(CAGR)

DNLI

-0.70%

Winner

USLM

+28.20%

Max(CAGR)

DNLI

-0.70%

Winner

USLM

+18.41%

DNLI vs USLM - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	DNLI	USLM
2026	+24.22%	-7.38%
2025	-20.78%	-1.75%
2024	-4.72%	+189.33%
2023	-22.33%	+68.82%
2022	-41.17%	+8.82%
2021	-37.06%	+12.51%
2020	+411.04%	+28.58%
2019	-9.88%	+33.64%
2018	+28.08%	-7.86%
2017	-27.09%	+4.41%
2016	N/A	+38.83%
2015	N/A	-22.95%
2014	N/A	+22.01%
2013	N/A	+23.60%
2012	N/A	-24.29%
2011	N/A	+36.92%
2010	N/A	+24.13%
2009	N/A	+38.12%
2008	N/A	-22.29%
2007	N/A	+1.47%
2006	N/A	+15.69%
2005	N/A	+136.55%
2004	N/A	+54.00%
2003	N/A	+80.11%
2002	N/A	-29.97%
2001	N/A	+15.25%
2000	N/A	-26.20%
1999	N/A	-8.63%

DNLI vs USLM Drawdown Comparison

The maximum drawdown for DNLI was -87.74%, occurring on Apr 8, 2025. This drawdown has not yet recovered.

The maximum drawdown for USLM was -62.52%, occurring on Apr 11, 2003. Recovery took 932 trading sessions.

The current DNLI drawdown is -78.40%. The current USLM drawdown is -28.69%.

Rank	DNLI	USLM
#1	-87.74% Dec 22, 2020 - Apr 8, 2025	-62.52% Mar 14, 2000 - Nov 28, 2003
#2	-49.76% Feb 16, 2018 - Apr 2, 2019	-58.98% Jun 23, 2008 - Jul 15, 2009
#3	-49.54% Apr 10, 2019 - Jun 2, 2020	-45.87% Nov 26, 2024 - Mar 10, 2025
#4	-29.88% Dec 8, 2017 - Jan 22, 2018	-38.36% Nov 12, 2014 - Nov 23, 2016
#5	-19.74% Jun 3, 2020 - Aug 6, 2020	-37.72% Feb 3, 2012 - Jun 9, 2014
#6	-19.58% Jan 29, 2018 - Feb 16, 2018	-35.13% Sep 27, 2005 - Aug 28, 2006
#7	-13.33% Nov 12, 2020 - Dec 4, 2020	-34.95% Dec 4, 2019 - Aug 12, 2020
#8	-11.16% Aug 10, 2020 - Aug 25, 2020	-33.44% Mar 10, 2021 - Feb 6, 2023
#9	-10.43% Sep 17, 2020 - Oct 7, 2020	-32.71% Mar 15, 2005 - Jun 10, 2005
#10	-10.33% Oct 13, 2020 - Oct 27, 2020	-30.26% Oct 17, 2017 - Nov 25, 2019
#11	-9.64% Aug 25, 2020 - Sep 14, 2020	-30.08% Jul 1, 2004 - Jan 31, 2005
#12	-7.28% Oct 28, 2020 - Nov 4, 2020	-29.47% Jul 21, 2009 - Oct 14, 2011
#13	-3.20% Jan 23, 2018 - Jan 26, 2018	-27.05% Jul 10, 2007 - Jun 9, 2008
#14	-2.37% Apr 3, 2019 - Apr 5, 2019	-23.04% Jan 20, 2004 - Jun 16, 2004
#15	-1.33% Dec 16, 2020 - Dec 18, 2020	-20.85% Nov 17, 1999 - Mar 2, 2000