DNLI vs LFST

Comparison between Denali Therapeutics Inc (DNLI, Company) and LifeStance Health Group Inc (LFST, Company).

Both DNLI and LFST are from the Healthcare sector.

5-Year PerformanceLFST has outperformed DNLI, delivering a return of -19.2% compared to -21.1%

DNLI vs LFST - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	DNLI(COMPANY)	LFST(COMPANY)
Market Cap	$2.99B	$2.98B
Max Drawdown	87.74%	86.91%
Sharpe Ratio	0.84	0.73
5Y Beta	1.56	0.74
Industry	Biotechnology	Medical Care Facilities
P/E Ratio	-5.62	128.43
Forward P/E	N/A	49.26
PEG Ratio	-0.88	N/A
Debt to Equity	0.00%	18.99%
Free Cash Flow Yield	-14.12%	4.79%
P/S Ratio	3643.65	1.92
P/B Ratio	3.10	1.99

Market Cap

Winner

DNLI

$2.99B

LFST

$2.98B

Max Drawdown

DNLI

87.74%

Winner

LFST

86.91%

Sharpe Ratio

Winner

DNLI

0.84

LFST

0.73

5Y Beta

DNLI

1.56

Winner

LFST

0.74

Industry

DNLI

Biotechnology

LFST

Medical Care Facilities

P/E Ratio

Winner

DNLI

-5.62

LFST

128.43

Forward P/E

DNLI

N/A

LFST

49.26

PEG Ratio

DNLI

-0.88

LFST

N/A

Debt to Equity

Winner

DNLI

0.00%

LFST

18.99%

Free Cash Flow Yield

DNLI

-14.12%

Winner

LFST

4.79%

P/S Ratio

DNLI

3643.65

Winner

LFST

1.92

P/B Ratio

DNLI

3.10

Winner

LFST

1.99

DNLI vs LFST - Historical Returns

Returns include dividend reinvestment.

Period	DNLI	LFST
1 month	+1.35%	+4.68%
3 months	-4.58%	+5.11%
6 months	+4.18%	+16.01%
1 year	+52.99%	+25.58%
5 years(CAGR)	-21.07%	-19.19%
10 years(CAGR)	-0.70%	N/A
Max(CAGR)	-0.70%	-19.19%

DNLI

+1.35%

Winner

LFST

+4.68%

DNLI

-4.58%

Winner

LFST

+5.11%

DNLI

+4.18%

Winner

LFST

+16.01%

Winner

DNLI

+52.99%

LFST

+25.58%

5Y(CAGR)

DNLI

-21.07%

Winner

LFST

-19.19%

10Y(CAGR)

DNLI

-0.70%

LFST

N/A

Max(CAGR)

Winner

DNLI

-0.70%

LFST

-19.19%

DNLI vs LFST - Annual Returns (2017 - 2026)

Returns include dividend reinvestment.

Year	DNLI	LFST
2026	+24.22%	+9.34%
2025	-20.78%	-6.75%
2024	-4.72%	-6.71%
2023	-22.33%	+68.39%
2022	-41.17%	-50.60%
2021	-37.06%	-56.53%
2020	+411.04%	N/A
2019	-9.88%	N/A
2018	+28.08%	N/A
2017	-27.09%	N/A

DNLI vs LFST Drawdown Comparison

The maximum drawdown for DNLI was -87.74%, occurring on Apr 8, 2025. This drawdown has not yet recovered.

The maximum drawdown for LFST was -86.91%, occurring on Aug 1, 2025. This drawdown has not yet recovered.

The current DNLI drawdown is -78.40%. The current LFST drawdown is -73.71%.

Rank	DNLI	LFST
#1	-87.74% Dec 22, 2020 - Apr 8, 2025	-86.91% Jul 7, 2021 - Aug 1, 2025
#2	-49.76% Feb 16, 2018 - Apr 2, 2019	-4.17% Jun 29, 2021 - Jul 7, 2021
#3	-49.54% Apr 10, 2019 - Jun 2, 2020	-0.84% Jun 18, 2021 - Jun 22, 2021
#4	-29.88% Dec 8, 2017 - Jan 22, 2018	-0.81% Jun 24, 2021 - Jun 29, 2021
#5	-19.74% Jun 3, 2020 - Aug 6, 2020	N/A
#6	-19.58% Jan 29, 2018 - Feb 16, 2018	N/A
#7	-13.33% Nov 12, 2020 - Dec 4, 2020	N/A
#8	-11.16% Aug 10, 2020 - Aug 25, 2020	N/A
#9	-10.43% Sep 17, 2020 - Oct 7, 2020	N/A
#10	-10.33% Oct 13, 2020 - Oct 27, 2020	N/A
#11	-9.64% Aug 25, 2020 - Sep 14, 2020	N/A
#12	-7.28% Oct 28, 2020 - Nov 4, 2020	N/A
#13	-3.20% Jan 23, 2018 - Jan 26, 2018	N/A
#14	-2.37% Apr 3, 2019 - Apr 5, 2019	N/A
#15	-1.33% Dec 16, 2020 - Dec 18, 2020	N/A