DNLI vs ORKA

Comparison between Denali Therapeutics Inc (DNLI, Company) and ARCA biopharma Inc (ORKA, Company).

Both DNLI and ORKA are from the Healthcare sector.

5-Year PerformanceORKA has outperformed DNLI, delivering a return of +26.4% compared to -18.7%

DNLI vs ORKA - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	DNLI(COMPANY)	ORKA(COMPANY)
Market Cap	$4.23B	$4.23B
Max Drawdown	87.74%	100.00%
Sharpe Ratio	1.17	2.68
5Y Beta	1.50	0.00
Industry	Biotechnology	Biotechnology
P/E Ratio	-7.97	-33.45
PEG Ratio	-1.24	N/A
5Y EPS CAGR	N/A	11.91%
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-9.97%	-2.15%
P/S Ratio	3643.65	N/A
P/B Ratio	4.43	10.62

Market Cap

Winner

DNLI

$4.23B

ORKA

$4.23B

Max Drawdown

Winner

DNLI

87.74%

ORKA

100.00%

Sharpe Ratio

DNLI

1.17

Winner

ORKA

2.68

5Y Beta

DNLI

1.50

Winner

ORKA

0.00

Industry

DNLI

Biotechnology

ORKA

Biotechnology

P/E Ratio

DNLI

-7.97

Winner

ORKA

-33.45

PEG Ratio

DNLI

-1.24

ORKA

N/A

5Y EPS CAGR

DNLI

N/A

ORKA

11.91%

Debt to Equity

DNLI

0.00%

ORKA

0.00%

Free Cash Flow Yield

DNLI

-9.97%

Winner

ORKA

-2.15%

P/S Ratio

DNLI

3643.65

ORKA

N/A

P/B Ratio

Winner

DNLI

4.43

ORKA

10.62

DNLI vs ORKA - Historical Returns

Returns include dividend reinvestment.

Period	DNLI	ORKA
1 month	+24.60%	+35.55%
3 months	+33.54%	+45.67%
6 months	+50.35%	+211.52%
1 year	+67.30%	+516.84%
5 years(CAGR)	-18.68%	+26.44%
10 years(CAGR)	+2.12%	-14.16%
Max(CAGR)	+2.12%	-28.21%

DNLI

+24.60%

Winner

ORKA

+35.55%

DNLI

+33.54%

Winner

ORKA

+45.67%

DNLI

+50.35%

Winner

ORKA

+211.52%

DNLI

+67.30%

Winner

ORKA

+516.84%

5Y(CAGR)

DNLI

-18.68%

Winner

ORKA

+26.44%

10Y(CAGR)

Winner

DNLI

+2.12%

ORKA

-14.16%

Max(CAGR)

Winner

DNLI

+2.12%

ORKA

-28.21%

DNLI vs ORKA - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	DNLI	ORKA
2026	+57.84%	+207.00%
2025	-20.78%	+51.78%
2024	-4.72%	+58.42%
2023	-22.33%	-29.75%
2022	-41.17%	+3.04%
2021	-37.06%	-48.32%
2020	+411.04%	-29.40%
2019	-9.88%	-3.87%
2018	+28.08%	-75.30%
2017	-27.09%	-50.18%
2016	N/A	-38.58%
2015	N/A	-36.13%
2014	N/A	-44.88%
2013	N/A	-31.71%
2012	N/A	-62.00%
2011	N/A	-68.25%
2010	N/A	-3.35%
2009	N/A	-49.06%
2008	N/A	-82.58%
2007	N/A	-51.72%
2006	N/A	-52.73%
2005	N/A	-17.66%
2004	N/A	+173.61%
2003	N/A	+321.69%
2002	N/A	-89.30%
2001	N/A	-47.20%
2000	N/A	-7.99%
1999	N/A	+209.27%

DNLI vs ORKA Drawdown Comparison

The maximum drawdown for DNLI was -87.74%, occurring on Apr 8, 2025. This drawdown has not yet recovered.

The maximum drawdown for ORKA was -100.00%, occurring on Apr 8, 2025. This drawdown has not yet recovered.

The current DNLI drawdown is -72.55%. The current ORKA drawdown is -100.00%.

Rank	DNLI	ORKA
#1	-87.74% Dec 22, 2020 - Apr 8, 2025	-100.00% Feb 18, 2000 - Apr 8, 2025
#2	-49.76% Feb 16, 2018 - Apr 2, 2019	-33.40% Jan 10, 2000 - Jan 24, 2000
#3	-49.54% Apr 10, 2019 - Jun 2, 2020	-23.62% Jan 25, 2000 - Feb 2, 2000
#4	-29.88% Dec 8, 2017 - Jan 22, 2018	-21.89% Dec 13, 1999 - Dec 27, 1999
#5	-19.74% Jun 3, 2020 - Aug 6, 2020	-16.91% Nov 1, 1999 - Nov 17, 1999
#6	-19.58% Jan 29, 2018 - Feb 16, 2018	-13.78% Dec 29, 1999 - Jan 6, 2000
#7	-13.33% Nov 12, 2020 - Dec 4, 2020	-7.08% Dec 7, 1999 - Dec 10, 1999
#8	-11.16% Aug 10, 2020 - Aug 25, 2020	-6.17% Nov 26, 1999 - Dec 2, 1999
#9	-10.43% Sep 17, 2020 - Oct 7, 2020	-5.92% Dec 2, 1999 - Dec 7, 1999
#10	-10.33% Oct 13, 2020 - Oct 27, 2020	-5.42% Nov 22, 1999 - Nov 26, 1999
#11	-9.64% Aug 25, 2020 - Sep 14, 2020	-5.14% Feb 3, 2000 - Feb 8, 2000
#12	-7.28% Oct 28, 2020 - Nov 4, 2020	-3.52% Feb 8, 2000 - Feb 10, 2000
#13	-3.20% Jan 23, 2018 - Jan 26, 2018	-3.34% Feb 10, 2000 - Feb 15, 2000
#14	-2.37% Apr 3, 2019 - Apr 5, 2019	N/A
#15	-1.33% Dec 16, 2020 - Dec 18, 2020	N/A