BMEZ vs SEPN

Comparison between BlackRock Health Sciences Term Trust (BMEZ, Company) and Septerna Inc (SEPN, Company).

BMEZ is from the Financial Services sector, while SEPN is from the Healthcare sector.

BMEZ vs SEPN - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	BMEZ(COMPANY)	SEPN(COMPANY)
Market Cap	$1.53B	$1.53B
Max Drawdown	57.56%	81.47%
Sharpe Ratio	0.97	1.78
5Y Beta	0.59	1.24
Industry	Asset Management	Biotechnology
P/E Ratio	5.72	-42.26
Forward P/E	N/A	107.53
5Y Dividends CAGR	2.28%	N/A
Debt to Equity	N/A	0.00%
Free Cash Flow Yield	N/A	6.99%
P/S Ratio	23.44	21.25
P/B Ratio	0.98	4.11

Market Cap

BMEZ

$1.53B

Winner

SEPN

$1.53B

Max Drawdown

Winner

BMEZ

57.56%

SEPN

81.47%

Sharpe Ratio

BMEZ

0.97

Winner

SEPN

1.78

5Y Beta

Winner

BMEZ

0.59

SEPN

1.24

Industry

BMEZ

Asset Management

SEPN

Biotechnology

P/E Ratio

BMEZ

5.72

Winner

SEPN

-42.26

Forward P/E

BMEZ

N/A

SEPN

107.53

5Y Dividends CAGR

BMEZ

2.28%

SEPN

N/A

Debt to Equity

BMEZ

N/A

SEPN

0.00%

Free Cash Flow Yield

BMEZ

N/A

SEPN

6.99%

P/S Ratio

BMEZ

23.44

Winner

SEPN

21.25

P/B Ratio

Winner

BMEZ

0.98

SEPN

4.11

BMEZ vs SEPN - Historical Returns

Returns include dividend reinvestment.

Period	BMEZ	SEPN
1 month	+5.48%	-3.36%
3 months	+8.54%	+30.54%
6 months	+2.82%	+27.82%
1 year	+20.78%	+173.60%
5 years(CAGR)	-2.05%	N/A
Max(CAGR)	+5.08%	+29.86%

Winner

BMEZ

+5.48%

SEPN

-3.36%

BMEZ

+8.54%

Winner

SEPN

+30.54%

BMEZ

+2.82%

Winner

SEPN

+27.82%

BMEZ

+20.78%

Winner

SEPN

+173.60%

5Y(CAGR)

BMEZ

-2.05%

SEPN

N/A

Max(CAGR)

BMEZ

+5.08%

Winner

SEPN

+29.86%

BMEZ vs SEPN - Annual Returns (2020 - 2026)

Returns include dividend reinvestment.

Year	BMEZ	SEPN
2026	+7.21%	+20.37%
2025	+18.07%	+30.59%
2024	+9.18%	+7.01%
2023	+3.31%	N/A
2022	-33.22%	N/A
2021	-7.99%	N/A
2020	+48.75%	N/A

BMEZ vs SEPN Drawdown Comparison

The maximum drawdown for BMEZ was -46.18%, occurring on May 11, 2022. This drawdown has not yet recovered.

The maximum drawdown for SEPN was -81.47%, occurring on Apr 1, 2025. Recovery took 230 trading sessions.

The current BMEZ drawdown is -14.06%. The current SEPN drawdown is -10.99%.

Rank	BMEZ	SEPN
#1	-46.18% Feb 12, 2021 - May 11, 2022	-81.47% Dec 23, 2024 - Nov 24, 2025
#2	-39.45% Feb 11, 2020 - Jul 6, 2020	-25.18% Feb 24, 2026 - May 28, 2026
#3	-9.99% Sep 1, 2020 - Oct 5, 2020	-21.10% Dec 19, 2025 - Feb 17, 2026
#4	-8.45% Oct 13, 2020 - Nov 5, 2020	-16.77% Dec 4, 2024 - Dec 23, 2024
#5	-8.29% Jan 20, 2021 - Feb 12, 2021	-16.60% Jul 9, 2026 - Jul 16, 2026
#6	-5.64% Dec 23, 2020 - Jan 14, 2021	-16.19% Nov 7, 2024 - Dec 4, 2024
#7	-4.23% Aug 7, 2020 - Aug 31, 2020	-13.97% Nov 26, 2025 - Dec 19, 2025
#8	-3.53% Nov 17, 2020 - Nov 25, 2020	-10.63% Feb 17, 2026 - Feb 24, 2026
#9	-2.49% Dec 2, 2020 - Dec 9, 2020	-10.36% Jun 26, 2026 - Jul 9, 2026
#10	-2.23% Jul 17, 2020 - Jul 28, 2020	-6.45% Oct 25, 2024 - Oct 31, 2024
#11	-2.04% Jul 29, 2020 - Aug 5, 2020	-5.55% Jun 23, 2026 - Jun 26, 2026
#12	-1.88% Jan 14, 2021 - Jan 20, 2021	-4.76% Oct 31, 2024 - Nov 4, 2024
#13	-1.82% Oct 7, 2020 - Oct 13, 2020	-3.65% Jun 18, 2026 - Jun 23, 2026
#14	-1.55% Dec 15, 2020 - Dec 22, 2020	-3.57% May 28, 2026 - Jun 4, 2026
#15	-1.36% Nov 6, 2020 - Nov 11, 2020	-3.45% Nov 4, 2024 - Nov 6, 2024