BCYC vs PALI

Comparison between Bicycle Therapeutics Plc (BCYC, Company) and Palisade Bio Inc (PALI, Company).

Both BCYC and PALI are from the Healthcare sector.

5-Year PerformanceBCYC has outperformed PALI, delivering a return of -33.0% compared to -77.7%

BCYC vs PALI - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	BCYC(COMPANY)	PALI(COMPANY)
Market Cap	$281M	$281M
Max Drawdown	93.41%	100.00%
Sharpe Ratio	-1.27	1.31
5Y Beta	1.28	0.00
Industry	Biotechnology	Biotechnology
P/E Ratio	-1.28	-9.72
PEG Ratio	-0.18	N/A
5Y EPS CAGR	11.06%	N/A
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-82.48%	-4.41%
P/S Ratio	4.43	11.78
P/B Ratio	0.51	2.29

Market Cap

BCYC

$281M

Winner

PALI

$281M

Max Drawdown

Winner

BCYC

93.41%

PALI

100.00%

Sharpe Ratio

BCYC

-1.27

Winner

PALI

1.31

5Y Beta

BCYC

1.28

Winner

PALI

0.00

Industry

BCYC

Biotechnology

PALI

Biotechnology

P/E Ratio

BCYC

-1.28

Winner

PALI

-9.72

PEG Ratio

BCYC

-0.18

PALI

N/A

5Y EPS CAGR

BCYC

11.06%

PALI

N/A

Debt to Equity

BCYC

0.00%

PALI

0.00%

Free Cash Flow Yield

BCYC

-82.48%

Winner

PALI

-4.41%

P/S Ratio

Winner

BCYC

4.43

PALI

11.78

P/B Ratio

Winner

BCYC

0.51

PALI

2.29

BCYC vs PALI - Historical Returns

Returns include dividend reinvestment.

Period	BCYC	PALI
1 month	-14.19%	-10.94%
3 months	-19.64%	-15.76%
6 months	-45.64%	-11.86%
1 year	-53.39%	+147.83%
5 years(CAGR)	-32.99%	-77.66%
10 years(CAGR)	N/A	-70.76%
Max(CAGR)	-14.27%	-51.59%

BCYC

-14.19%

Winner

PALI

-10.94%

BCYC

-19.64%

Winner

PALI

-15.76%

BCYC

-45.64%

Winner

PALI

-11.86%

BCYC

-53.39%

Winner

PALI

+147.83%

5Y(CAGR)

Winner

BCYC

-32.99%

PALI

-77.66%

10Y(CAGR)

BCYC

N/A

PALI

-70.76%

Max(CAGR)

Winner

BCYC

-14.27%

PALI

-51.59%

BCYC vs PALI - Annual Returns (2006 - 2026)

Returns include dividend reinvestment.

Year	BCYC	PALI
2026	-39.37%	-31.60%
2025	-50.70%	+26.34%
2024	-24.08%	-81.00%
2023	-39.73%	-84.55%
2022	-50.25%	-93.11%
2021	+217.03%	-78.96%
2020	+82.79%	-20.00%
2019	-21.42%	-84.99%
2018	N/A	-84.58%
2017	N/A	-57.46%
2016	N/A	-73.46%
2015	N/A	-63.35%
2014	N/A	-13.92%
2013	N/A	+140.50%
2012	N/A	+9.00%
2011	N/A	-55.53%
2010	N/A	+14.59%
2009	N/A	+7.19%
2008	N/A	-55.00%
2007	N/A	+48.02%
2006	N/A	+50.00%

BCYC vs PALI Drawdown Comparison

The maximum drawdown for BCYC was -93.41%, occurring on Jun 10, 2026. This drawdown has not yet recovered.

The maximum drawdown for PALI was -100.00%, occurring on Sep 10, 2025. This drawdown has not yet recovered.

The current BCYC drawdown is -93.38%. The current PALI drawdown is -100.00%.

Rank	BCYC	PALI
#1	-93.41% Nov 15, 2021 - Jun 10, 2026	-100.00% Apr 9, 2014 - Sep 10, 2025
#2	-53.96% Jun 19, 2019 - Feb 14, 2020	-88.86% Apr 26, 2007 - Mar 17, 2014
#3	-41.61% Mar 10, 2020 - May 28, 2020	-24.62% Jan 10, 2007 - Mar 26, 2007
#4	-25.95% Feb 5, 2021 - Apr 1, 2021	-18.87% Mar 20, 2014 - Apr 9, 2014
#5	-20.84% Jul 23, 2021 - Aug 30, 2021	-16.00% Dec 29, 2006 - Jan 10, 2007
#6	-18.83% Feb 26, 2020 - Mar 4, 2020	-16.00% Dec 21, 2006 - Dec 29, 2006
#7	-18.70% Jul 15, 2020 - Sep 16, 2020	-7.58% Mar 26, 2007 - Apr 13, 2007
#8	-16.36% Apr 8, 2021 - Jul 13, 2021	-5.95% Mar 17, 2014 - Mar 20, 2014
#9	-15.98% Jun 8, 2020 - Jul 14, 2020	-5.63% Apr 18, 2007 - Apr 26, 2007
#10	-15.96% Nov 30, 2020 - Jan 14, 2021	N/A
#11	-15.70% Mar 4, 2020 - Mar 10, 2020	N/A
#12	-14.32% Jan 19, 2021 - Feb 5, 2021	N/A
#13	-14.18% May 24, 2019 - Jun 14, 2019	N/A
#14	-13.83% Oct 14, 2021 - Nov 15, 2021	N/A
#15	-12.02% Sep 21, 2020 - Nov 17, 2020	N/A