BCYC vs OSUR

Comparison between Bicycle Therapeutics Plc (BCYC, Company) and Orasure Technologies Inc (OSUR, Company).

Both BCYC and OSUR are from the Healthcare sector.

5-Year PerformanceOSUR has outperformed BCYC, delivering a return of -15.4% compared to -33.0%

BCYC vs OSUR - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	BCYC(COMPANY)	OSUR(COMPANY)
Market Cap	$281M	$280M
Max Drawdown	93.41%	90.75%
Sharpe Ratio	-1.22	0.86
5Y Beta	1.28	1.12
Industry	Biotechnology	Medical Instruments & Supplies
P/E Ratio	-1.28	-3.83
Forward P/E	N/A	40.00
PEG Ratio	-0.18	-0.03
5Y EPS CAGR	11.06%	81.11%
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-82.48%	-17.12%
P/S Ratio	4.43	2.58
P/B Ratio	0.51	0.93

Market Cap

Winner

BCYC

$281M

OSUR

$280M

Max Drawdown

BCYC

93.41%

Winner

OSUR

90.75%

Sharpe Ratio

BCYC

-1.22

Winner

OSUR

0.86

5Y Beta

BCYC

1.28

Winner

OSUR

1.12

Industry

BCYC

Biotechnology

OSUR

Medical Instruments & Supplies

P/E Ratio

BCYC

-1.28

Winner

OSUR

-3.83

Forward P/E

BCYC

N/A

OSUR

40.00

PEG Ratio

Winner

BCYC

-0.18

OSUR

-0.03

5Y EPS CAGR

BCYC

11.06%

Winner

OSUR

81.11%

Debt to Equity

BCYC

0.00%

OSUR

0.00%

Free Cash Flow Yield

BCYC

-82.48%

Winner

OSUR

-17.12%

P/S Ratio

BCYC

4.43

Winner

OSUR

2.58

P/B Ratio

Winner

BCYC

0.51

OSUR

0.93

BCYC vs OSUR - Historical Returns

Returns include dividend reinvestment.

Period	BCYC	OSUR
1 month	-14.19%	+40.74%
3 months	-19.64%	+35.28%
6 months	-45.64%	+67.87%
1 year	-53.39%	+42.66%
5 years(CAGR)	-32.99%	-15.40%
10 years(CAGR)	N/A	-4.79%
Max(CAGR)	-14.27%	-0.38%

BCYC

-14.19%

Winner

OSUR

+40.74%

BCYC

-19.64%

Winner

OSUR

+35.28%

BCYC

-45.64%

Winner

OSUR

+67.87%

BCYC

-53.39%

Winner

OSUR

+42.66%

5Y(CAGR)

BCYC

-32.99%

Winner

OSUR

-15.40%

10Y(CAGR)

BCYC

N/A

OSUR

-4.79%

Max(CAGR)

BCYC

-14.27%

Winner

OSUR

-0.38%

BCYC vs OSUR - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	BCYC	OSUR
2026	-39.37%	+75.63%
2025	-50.70%	-31.64%
2024	-24.08%	-56.40%
2023	-39.73%	+71.19%
2022	-50.25%	-44.34%
2021	+217.03%	-22.48%
2020	+82.79%	+34.16%
2019	-21.42%	-31.19%
2018	N/A	-39.45%
2017	N/A	+114.56%
2016	N/A	+38.27%
2015	N/A	-35.28%
2014	N/A	+56.72%
2013	N/A	-13.24%
2012	N/A	-24.50%
2011	N/A	+51.58%
2010	N/A	+8.70%
2009	N/A	+38.80%
2008	N/A	-57.80%
2007	N/A	+9.08%
2006	N/A	-9.43%
2005	N/A	+33.64%
2004	N/A	-15.15%
2003	N/A	+41.13%
2002	N/A	-55.33%
2001	N/A	+61.33%
2000	N/A	+28.11%
1999	N/A	+40.39%

BCYC vs OSUR Drawdown Comparison

The maximum drawdown for BCYC was -93.41%, occurring on Jun 10, 2026. This drawdown has not yet recovered.

The maximum drawdown for OSUR was -90.75%, occurring on Nov 20, 2025. This drawdown has not yet recovered.

The current BCYC drawdown is -93.38%. The current OSUR drawdown is -81.67%.

Rank	BCYC	OSUR
#1	-93.41% Nov 15, 2021 - Jun 10, 2026	-90.75% Oct 2, 2017 - Nov 20, 2025
#2	-53.96% Jun 19, 2019 - Feb 14, 2020	-86.76% Mar 13, 2000 - Jun 27, 2017
#3	-41.61% Mar 10, 2020 - May 28, 2020	-20.73% Jan 21, 2000 - Feb 10, 2000
#4	-25.95% Feb 5, 2021 - Apr 1, 2021	-12.68% Dec 2, 1999 - Dec 21, 1999
#5	-20.84% Jul 23, 2021 - Aug 30, 2021	-12.00% Feb 10, 2000 - Feb 17, 2000
#6	-18.83% Feb 26, 2020 - Mar 4, 2020	-11.20% Nov 2, 1999 - Dec 1, 1999
#7	-18.70% Jul 15, 2020 - Sep 16, 2020	-10.71% Jan 10, 2000 - Jan 13, 2000
#8	-16.36% Apr 8, 2021 - Jul 13, 2021	-10.01% Jul 17, 2017 - Aug 3, 2017
#9	-15.98% Jun 8, 2020 - Jul 14, 2020	-9.19% Dec 30, 1999 - Jan 6, 2000
#10	-15.96% Nov 30, 2020 - Jan 14, 2021	-8.33% Feb 17, 2000 - Mar 1, 2000
#11	-15.70% Mar 4, 2020 - Mar 10, 2020	-6.94% Aug 8, 2017 - Sep 7, 2017
#12	-14.32% Jan 19, 2021 - Feb 5, 2021	-5.43% Jan 19, 2000 - Jan 21, 2000
#13	-14.18% May 24, 2019 - Jun 14, 2019	-5.04% Mar 6, 2000 - Mar 9, 2000
#14	-13.83% Oct 14, 2021 - Nov 15, 2021	-3.25% Jun 29, 2017 - Jul 5, 2017
#15	-12.02% Sep 21, 2020 - Nov 17, 2020	-3.07% Jul 5, 2017 - Jul 10, 2017